Lipid accumulation product and insulin resistance in Iranian PCOS prevalence study

2013 ◽  
Vol 81 (1) ◽  
pp. 52-57 ◽  
Author(s):  
Farhad Hosseinpanah ◽  
Maryam Barzin ◽  
Hadi Erfani ◽  
Sara Serahati ◽  
Fahimeh Ramezani Tehrani ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Lipid Accumulation ◽  
Prevalence Study ◽  
Lipid Accumulation Product

scholarly journals The “Lipid Accumulation Product” Is Associated with 2-Hour Postload Glucose Outcomes in Overweight/Obese Subjects with Nondiabetic Fasting Glucose

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Alexis Elias Malavazos ◽  
Emanuele Cereda ◽  
Federica Ermetici ◽  
Riccardo Caccialanza ◽  
Silvia Briganti ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Glucose Tolerance ◽  
Lipid Accumulation ◽  
Fasting Glucose ◽  
Tolerance Test ◽  
Continuous Variable ◽  
Oral Glucose ◽  
Model Assessment ◽  
Lipid Accumulation Product ◽  
Adult Age

“Lipid accumulation product” (LAP) is a continuous variable based on waist circumference and triglyceride concentration previously associated with insulin resistance. We investigated the accuracy of LAP in identifying oral glucose tolerance test (OGTT) abnormalities and compared it to the homeostasis model assessment of insulin resistance (HOMA-IR) in a population of overweight/obese outpatients presenting with nondiabetic fasting glucose. We studied 381 (male: 23%) adult (age: 18–70 years) overweight/obese Caucasians (body mass index: 36.9 ± 5.4 Kg/m2) having fasting plasma glucose < 7.0 mmol/L. OGTT was used to diagnose unknown glucose tolerance abnormalities: impaired glucose tolerance (IGT) and type-2 diabetes mellitus (T2-DM). According to OGTT 92, subjects had an IGT and 33 were diagnosed T2-DM. Logistic regression analysis detected a significant association for both LAP and HOMA-IR with single (IGT and T2-DM) and composite (IGT + T2-DM) abnormal glucose tolerance conditions. However, while the association with diabetes was similar between LAP and HOMA-IR, the relationship with IGT and composite outcomes by models including LAP was significantly superior to those including HOMA-IR (P=0.006andP=0.007, resp.). LAP seems to be an accurate index, performing better than HOMA-IR, for identifying 2-hour postload OGTT outcomes in overweight/obese patients with nondiabetic fasting glucose.

Lipid accumulation product and triglycerides/glucose index are useful predictors of insulin resistance

2018 ◽  
Vol 32 (3) ◽  
pp. 266-270 ◽  
Author(s):  
Mohsen Mazidi ◽  
Andre-Pascal Kengne ◽  
Niki Katsiki ◽  
Dimitri P. Mikhailidis ◽  
Maciej Banach
Keyword(s):  
Insulin Resistance ◽  
Lipid Accumulation ◽  
Lipid Accumulation Product

scholarly journals Lipid Accumulation Product Is More Related to Insulin Resistance than the Visceral Adiposity Index in the Maracaibo City Population, Venezuela

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Valmore Bermúdez ◽  
Juan Salazar ◽  
Jorge Fuenmayor ◽  
Manuel Nava ◽  
Ángel Ortega ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Logistic Regression ◽  
Lipid Accumulation ◽  
Adult Population ◽  
Visceral Adiposity ◽  
Bivariate Analysis ◽  
Visceral Adiposity Index ◽  
Lipid Accumulation Product ◽  
Adiposity Index ◽  
City Population

Background. Visceral adiposity is related to insulin resistance (IR), a metabolic state considered as a risk factor for other cardiometabolic diseases. In that matter, mathematical indexes such as the visceral adiposity index (VAI) and the lipid accumulation product (LAP) could indirectly assess IR based on visceral adiposity. Objective. To evaluate the association and diagnostic accuracy of VAI and LAP to diagnose IR in the adult population of Maracaibo city. Methods. This is a cross-sectional descriptive study with multistage sampling. Receiver operating characteristic (ROC) curves were built to determine VAI and LAP cutoff points to predict IR. A set of logistic regression models was constructed according to sociodemographic, psychobiologic, and metabolic variables. Results. 1818 subjects were evaluated (51.4% women). The area under the curve (AUC) values for LAP and VAI were 0.689 (0.665–0.714) and 0.645 (0.619–0.670), respectively. Both indexes showed a higher IR risk in the upper tertile in bivariate analysis. However, in the logistic regression analysis for the IR risk, only the 2nd (OR: 1.91; 95% CI: 1.37–2.65; p < 0.01 ) and 3rd (OR: 5.40; 95% CI: 3.48–8.39; p < 0.01 ) LAP tertiles showed a significant increase. This behaviour was also observed after adjusting for hs-C-reactive protein (hs-CPR). Conclusion. Although both indexes show a low predictive capacity in individuals with IR in the Maracaibo city population, the LAP index was more strongly associated with IR.

scholarly journals Lipid accumulation product (LAP) as a potential index to predict risk of insulin resistance in young, non-obese Asian Indian males from Southern India: observations from hyperinsulinemic-euglycemic clamp studies

2021 ◽  
Vol 9 (1) ◽  
pp. e002414
Author(s):  
Shajith Anoop S ◽  
Riddhi Dasgupta ◽  
Grace Rebekah ◽  
Arun Jose ◽  
Mercy Prem Inbakumari ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Insulin Sensitivity ◽  
Asian Indian ◽  
Lipid Accumulation ◽  
Predictive Accuracy ◽  
Southern India ◽  
Whole Body ◽  
Lipid Accumulation Product ◽  
Euglycemic Clamp ◽  
Hyperinsulinemic Euglycemic Clamp

IntroductionWe aimed to compare the predictive accuracy of surrogate indices namely the lipid accumulation product (LAP) index, homeostatic model of assessment of insulin resistance (HOMA-IR), fasting glucose-insulin ratio (FG-IR) and the quantitative-insulin sensitivity check index (QUICKI), against the M value of hyperinsulinemic-euglycemic clamp (HEC), and to determine a cut-off value for the LAP index to predict risk of insulin resistance in non-obese (body mass index <21 kg/m2), normoglycemic, Asian Indian males from Southern India.Research design and methodsData of HEC studies performed in 108 non-obese, normoglycemic, Asian Indian males was obtained retrospectively and the M value (a measure of whole-body insulin sensitivity) was calculated. The M value is the rate of whole-body glucose metabolism at the hyperinsulinemic plateau (a measure of insulin sensitivity) and is calculated between 60 and 120 min after the start of the insulin infusion in the HEC procedure. The LAP index, the HOMA-IR, FG-IR and QUICKI were calculated. Spearman’s correlation and logistic regression analysis were performed. Cut-off value for the LAP index was obtained using receiver operating characteristics with area under curve (AUC) analysis at 95% CI. P value <0.05 was considered to be statistically significant.ResultsSignificant negative correlation was observed for the M value with LAP index (r=−0.39, p<0.001) while significant positive correlation was noted with FG-IR (r=0.25; p<0.01) and QUICKI (r=0.22; p<0.01). The LAP index cut-off value ≥33.4 showed 75% sensitivity and 75% specificity with AUC (0.72) to predict risk of insulin resistance in this cohort.ConclusionThe LAP index showed higher predictive accuracy for the risk of insulin resistance as compared with HOMA-IR, QUICKI and FG-IR in non-obese, normoglycemic Asian Indian males from Southern India.

scholarly journals Increased Leukotriene B4 Plasma Concentration in Type 2 Diabetes Individuals with Cardiovascular Autonomic Neuropathy

2020 ◽  
Author(s):  
JOSE ANTONIO JANUARIO NEVES ◽  
MOZÂNIA REIS DE MATOS ◽  
THERESA RAMALHO ◽  
DANIELE PEREIRA SANTOS-BEZERRA ◽  
CRISTIANE DAS GRAÇAS DIAS CAVALCANTE ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Plasma Concentration ◽  
Glycemic Control ◽  
Autonomic Neuropathy ◽  
Inflammatory Mediators ◽  
Lipid Accumulation ◽  
Surrogate Marker ◽  
Leukotriene B4 ◽  
Lipid Accumulation Product ◽  
Lipid Accumulation Product Index

Abstract Background and Aim: A low-grade inflammation is associated with cardiac autonomic neuropathy (CAN) and increased concentration of leukotriene B4 (LTB4) was found in individuals with type 1 diabetes and definitive CAN. This cross-sectional study evaluated plasma concentration of LTB4 and of other inflammatory mediators, namely, tumor necrosis factor (TNF), interleukin (IL)1B, and IL10 in individuals with T2D and different degrees of CAN, and correlated these inflammatory mediators with the degree of glycemic control and with a surrogate marker of insulin resistance. Methods: TNF, IL1B, IL10 and LTB4 plasma concentrations were measured in 129 T2D subjects (62% women with [median] age of 63 years, disease duration of 8 years and HbA1c of 7.3%) with or without CAN. The Lipid accumulation product index was used as a surrogate marker of insulin resistance. Results LTB4 concentration was significantly higher in those presenting incipient CAN (69.7 ± 16.6 pg. mL-1) and definitive CAN (71.5 ± 15.7 pg. mL-1) versus those without CAN (57.0 ± 13.9 pg. mL-1). The groups without CAN and with incipient CAN were pooled (group without definitive CAN) and compared to those with definitive CAN. LTB4 concentration was higher in the latter group, as well as TNF concentration, while IL10 concentration was lower in this group. After adjustment for confounding variables, only LTB4 concentration remained significantly different between the groups with and without definitive CAN. Plasma concentration of LTB4 did not correlate with the degree of glycemic control. After sorting the participants by sex, a borderline weak correlation was found between LTB4 and the Lipid accumulation product index in women. Conclusion: In the T2D setting, circulating LTB4 concentration seems to be associated with cardiovascular dysautonomia.

Insulin Resistance and Lipid Accumulation Product in Corelation to Body Mass Index in Women with Polycystic Ovary Syndrome

2012 ◽  
Vol 66 (6) ◽  
pp. 409 ◽  
Author(s):  
Amina Godinjak ◽  
Zulfo Godinjak ◽  
Azra Burekovic ◽  
Ismana Surkovic ◽  
Amela DizdarevicBostandzic ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Body Mass Index ◽  
Polycystic Ovary Syndrome ◽  
Body Mass ◽  
Lipid Accumulation ◽  
Polycystic Ovary ◽  
Lipid Accumulation Product ◽  
Ovary Syndrome

scholarly journals The Lipid Accumulation Product for the Early Prediction of Gestational Insulin Resistance and Glucose Dysregulation

2013 ◽  
Vol 22 (4) ◽  
pp. 362-367 ◽  
Author(s):  
Diane Brisson ◽  
Patrice Perron ◽  
Henry S. Kahn ◽  
Daniel Gaudet ◽  
Luigi Bouchard
Keyword(s):  
Insulin Resistance ◽  
Lipid Accumulation ◽  
Early Prediction ◽  
Lipid Accumulation Product ◽  
Glucose Dysregulation
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