scholarly journals Vogt–Koyanagi–Harada patients show higher frequencies of circulating NKG2D pos NK and NK T cells

2020 ◽  
Author(s):  
M. Bonacini ◽  
L. Cimino ◽  
L. De Simone ◽  
E. Bolletta ◽  
F. Gozzi ◽  
...  
Keyword(s):  
T Cells ◽  
Nk T Cells

scholarly journals Loss of IFN-γ Production by Invariant NK T Cells in Advanced Cancer

2001 ◽  
Vol 167 (7) ◽  
pp. 4046-4050 ◽  
Author(s):  
Syed Muhammad Ali Tahir ◽  
Olivia Cheng ◽  
Angela Shaulov ◽  
Yasuhiko Koezuka ◽  
Glenn J. Bubley ◽  
...  
Keyword(s):  
T Cells ◽  
Advanced Cancer ◽  
Nk T Cells ◽  
Ifn Γ

scholarly journals Development of an IL-15–autocrine CD8 T-cell leukemia in IL-15–transgenic mice requires the cis expression of IL-15Rα

Blood ◽  
2011 ◽  
Vol 117 (15) ◽  
pp. 4032-4040 ◽  
Author(s):  
Noriko Sato ◽  
Helen Sabzevari ◽  
Song Fu ◽  
Wei Ju ◽  
Michael N. Petrus ◽  
...  
Keyword(s):  
T Cells ◽  
Transgenic Mice ◽  
Cd8 T Cells ◽  
Constitutive Expression ◽  
Γδ T Cells ◽  
Selective Advantage ◽  
Intraepithelial Lymphocytes ◽  
Leukemic Transformation ◽  
Nk T Cells ◽  
Growth Promoting

AbstractIL-15 has growth-promoting effects on select lymphoid subsets, including natural killer (NK) cells, NK T cells, intraepithelial lymphocytes (IELs), CD8 T cells, and γδ-T cells. Constitutive expression of murine IL-15 in IL-15–transgenic mice was reported to cause T-NK leukemia. We investigated whether IL-15 expression is sufficient for leukemic transformation using a human IL-15–transgenic (IL-15Tg) mouse model. We noted that 100% of the mice observed over a 2-year period (n > 150) developed fatal expansions of CD8 T cells with NK markers, and determined that these cells expressed IL-15 receptor alpha (IL-15Rα). The expression of IL-15Rα on CD8 T cells appears to be required for uncontrolled aggressive lymphoproliferation, because none of the IL-15Rα−/−–IL-15Tg mice that we followed for more than 2 years developed the fatal disease despite controlled expansion of CD8 T cells. In addition, in contrast to IL-15Tg mice, in which leukemia-like CD8 T cells expressed IL-15Rα persistently, acutely activated normal CD8 T cells only transiently expressed IL-15Rα. Inhibition of DNA methylation enabled sustained IL-15Rα expression induced by activation. We present a scenario for IL-15Tg mice in which CD8 T cells that acquire constitutive persistent IL-15Rα expression are at a selective advantage and become founder cells, outgrow other lymphocytes, and lead to the establishment of a leukemia-like condition.

scholarly journals Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis

2004 ◽  
Vol 113 (10) ◽  
pp. 1490-1497 ◽  
Author(s):  
Ivan J. Fuss ◽  
Frank Heller ◽  
Monica Boirivant ◽  
Francisco Leon ◽  
Masaru Yoshida ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
T Cells ◽  
Th2 Response ◽  
Nk T Cells

scholarly journals A Critical Role for Natural Killer T Cells in Immunosurveillance of Methylcholanthrene-induced Sarcomas

2002 ◽  
Vol 196 (1) ◽  
pp. 119-127 ◽  
Author(s):  
Nadine Y. Crowe ◽  
Mark J. Smyth ◽  
Dale I. Godfrey
Keyword(s):  
T Cells ◽  
T Cell ◽  
Natural Killer ◽  
Critical Role ◽  
Physiological Role ◽  
Cell Receptor ◽  
Interferon Γ ◽  
Tumor Rejection ◽  
Nk T Cells ◽  
Nk T Cell

Natural killer (NK) T cells initiate potent antitumor responses when stimulated by exogenous factors such as interleukin (IL)-12 or α-galactosylceramide (α-GalCer), however, it is not clear whether this reflects a physiological role for these cells in tumor immunity. Through adoptive transfer of NK T cells from wild-type to NK T cell–deficient (T cell receptor [TCR] Jα281−/−) mice, we demonstrate a critical role for NK T cells in immunosurveillance of methylcholanthrene (MCA)-induced fibrosarcomas, in the absence of exogenous stimulatory factors. Using the same approach with gene-targeted and/or antibody-depleted donor or recipient mice, we have shown that this effect depends on CD1d recognition and requires the additional involvement of both NK and CD8+ T cells. Interferon-γ production by both NK T cells and downstream, non-NK T cells, is essential for protection, and perforin production by effector cells, but not NK T cells, is also critical. The protective mechanisms in this more physiologically relevant system are distinct from those associated with α-GalCer–induced, NK T cell–mediated, tumor rejection. This study demonstrates that, in addition to their importance in tumor immunotherapy induced by IL-12 or α-GalCer, NK T cells can play a critical role in tumor immunosurveillance, at least against MCA-induced sarcomas, in the absence of exogenous stimulation.

Increased Interleukin-4 Production by NK T Cells in Systemic Lupus Erythematosus

1999 ◽  
Vol 92 (2) ◽  
pp. 197-202 ◽  
Author(s):  
M. Funauchi ◽  
H. Yu ◽  
M. Sugiyama ◽  
S. Ikoma ◽  
M. Ohno ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
T Cells ◽  
Lupus Erythematosus ◽  
Interleukin 4 ◽  
Systemic Lupus ◽  
Nk T Cells

scholarly journals Activated T Cells and Soluble Molecules in the Portal Venous Blood of Patients with Cholestatic and Hepatitis C Virus-Positive Liver Cirrhosis. Possible Promotion of Fas/FasL-Mediated Apoptosis in the Bile-Duct Cells and Hepatocyte Injury

2003 ◽  
Vol 31 (3) ◽  
pp. 170-180 ◽  
Author(s):  
N Ariki ◽  
Y Morimoto ◽  
T Yagi ◽  
T Oyama ◽  
Y Cyouda ◽  
...  
Keyword(s):  
T Cells ◽  
Liver Cirrhosis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Bile Duct ◽  
Venous Blood ◽  
Activated T Cells ◽  
Peripheral Venous Blood ◽  
Nk T Cells ◽  
Portal Venous Blood

We investigated the immune responses of patients with cholestatic and hepatitis C virus-positive (HCV-positive) liver cirrhosis by analysing T-cell subsets and cytokine levels in the portal and peripheral veins, using flow cytometry and enzyme-linked immunosorbent assay. In cholestatic liver cirrhosis, the proportion of natural-killer (NK) T cells and interleukin (IL) 6 and IL-18 levels in the portal venous blood were significantly higher than those in the peripheral venous blood. In HCV-positive liver cirrhosis, the proportions of NK T cells and Fas+ T cells and IL-6 and soluble Fas levels in the portal venous blood were significantly higher than those in the peripheral venous blood. These results suggest that in these diseases, activated T cells and soluble molecules in portal venous blood may promote Fas/FasL-mediated apoptosis of the bile-duct cells and hepatocytes, and contribute to the deterioration in liver function as an inevitable result of positive feedback.

Evaluation of NK T Cells in Patients with Schistosomiasis and Asthma

2006 ◽  
Vol 117 (2) ◽  
pp. S102
Author(s):  
R.A. Campos ◽  
M.S. Teles ◽  
M.J. Martins ◽  
O.F. Jesus ◽  
B.B. Andrade ◽  
...  
Keyword(s):  
T Cells ◽  
Nk T Cells
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