scholarly journals Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis

2004 ◽  
Vol 113 (10) ◽  
pp. 1490-1497 ◽  
Author(s):  
Ivan J. Fuss ◽  
Frank Heller ◽  
Monica Boirivant ◽  
Francisco Leon ◽  
Masaru Yoshida ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
T Cells ◽  
Th2 Response ◽  
Nk T Cells

IL-13 secretion by CD4+CD161+ NK-T cells is increased in oxazolone and human ulcerative colitis (UC)

2003 ◽  
Vol 124 (4) ◽  
pp. A35-A36 ◽  
Author(s):  
Frank Heller ◽  
Monica Boirivant ◽  
Peter Mannon ◽  
Richard S. Blumberg ◽  
Edward Nieuwenhaus ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
T Cells ◽  
Nk T Cells

scholarly journals Oxazolone Colitis, a Th2 Colitis Model Resembling Ulcerative Colitis, Is Mediated by IL-13-Producing NK-T Cells

Immunity ◽  
2002 ◽  
Vol 17 (5) ◽  
pp. 629-638 ◽  
Author(s):  
Frank Heller ◽  
Ivan J Fuss ◽  
Edward E Nieuwenhuis ◽  
Richard S Blumberg ◽  
Warren Strober
Keyword(s):  
Ulcerative Colitis ◽  
T Cells ◽  
Nk T Cells ◽  
Colitis Model

scholarly journals P819 Seroprevalence of Borrelia burgdorferi antibodies in patients with ulcerative colitis

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S637-S637
Author(s):  
A C Dulger
Keyword(s):  
Ulcerative Colitis ◽  
T Cells ◽  
Lyme Disease ◽  
Borrelia Burgdorferi ◽  
The Other ◽  
Inverse Association ◽  
Other Hand ◽  
Wide Range ◽  
Nk T Cells ◽  
Ig G

Abstract Background Lyme disease is a significant zoonotic tick-borne disease with an increasing prevalence in northern hemisphere. The infected tick of the genus Ixodes is responsible for spreading of the disease. Erythema migrans lesions, cranial-nerve (particularlyfacial-nerve) palsy and meningitis, carditis and arthritis are the main manifestations of the disease. Diagnosis of Lyme disease mainly depends on medical history, compatible clinical signs in connection with laboratory findings including more than two IgM bands or more than 5 IgG bands on immunoblot. Ulcerative colitis (UC) is a immun-mediated large bowel disease that is characterised by abdominal pain, bloody diarrhoea and tenesmus due to lymphoplasmocyter infiltration of the mucosal crypts. There have been many studies describing a wide range of genetic, immunologic and environmental risk factors in patients with UC. However, there is no report whether Borrelia burgdorferi antibodies are protective in patients with UC. Methods This was a single centre retrospective observational study of patients with UC vs. age and -matched healthy controls. The medical records of gastroenterology clinic patients with UC between July 2018 and May 2019 were reviewed. At total, 51 (15 female; the mean age 46 years; 35 of them were using anti-TNF agents) UC patients have tested for Borrelia antibodies. On the other hand, 66 age-matched otherwise healthy control subjects (36 female; mean age was 54 years) were selected as comparator group. Results While, only 2 patients (3%) were tested positive for Borrelia bugdorferi (BB) Ig G antibody, 15 subjects (22.7%) had a positive result for BB Ig G antibody in control group. There was a significant difference between groups in terms of BB Ig G seropositivity (p < 0.001). found significantly low rates of BB Ig g seroprevalance in patients with UC. The reason of this phenomenon is unclear. Conclusion The low rate of BB Ig G in patients with UC may have been related to presence of aberrant NK T cells in colonic mucosa. Evidence suggests a inverse link between Lyme arthritis and elevated levels of NK T cells, therefore we hypothesise that UC-related T cells regulates Borrelia trafficking. On the other hand, it has been a well known fact that UC is also related to improvement in sociodemographic development in developing world. Lyme disease is mostly driven by tick exposure in rural areas and mostly seen in forestal areas of the world rather than city centres. This phenomenon may also compatible with real life prevalence models of the inflammatory bowel diseases. In conclusion, these data indicate, for the first time, the inverse association between UC and seropositivity of BB antibodies could lead to design new diagnostic and prognostic tools.

scholarly journals Production of Both IL-27 and IFN-γ after the Treatment with a Ligand for Invariant NK T Cells Is Responsible for the Suppression of Th2 Response and Allergic Inflammation in a Mouse Experimental Asthma Model

2009 ◽  
Vol 183 (1) ◽  
pp. 254-260 ◽  
Author(s):  
Hiroyuki Fujita ◽  
Annabelle Teng ◽  
Risa Nozawa ◽  
Yukiko Takamoto-Matsui ◽  
Haruka Katagiri-Matsumura ◽  
...  
Keyword(s):  
T Cells ◽  
Allergic Inflammation ◽  
Th2 Response ◽  
Asthma Model ◽  
Nk T Cells ◽  
Ifn Γ

Deficiency of Invariant NK T Cells in Crohn's Disease and Ulcerative Colitis

2007 ◽  
Vol 52 (6) ◽  
pp. 1415-1422 ◽  
Author(s):  
Randall H. Grose ◽  
Fiona M. Thompson ◽  
Alan G. Baxter ◽  
Daniel G. Pellicci ◽  
Adrian G. Cummins
Keyword(s):  
Ulcerative Colitis ◽  
T Cells ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Nk T Cells

scholarly journals The role of IL-13 and NK T cells in experimental and human ulcerative colitis

2008 ◽  
Vol 1 (S1) ◽  
pp. S31-S33 ◽  
Author(s):  
I J Fuss ◽  
W Strober
Keyword(s):  
Ulcerative Colitis ◽  
T Cells ◽  
Nk T Cells
Sign in / Sign up

Export Citation Format

Share Document