scholarly journals Elevated CD8 T cell responses in type 1 diabetes patients to a 13 amino acid coeliac-active peptide from α-gliadin

2014 ◽  
Vol 175 (2) ◽  
pp. 167-171 ◽  
Author(s):  
W. E. Barbeau ◽  
R. Hontecillas ◽  
W. Horne ◽  
A. Carbo ◽  
M. H. Koch ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Amino Acid ◽  
T Cell ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Active Peptide ◽  
Cell Responses ◽  
Diabetes Patients

scholarly journals Identification of autoreactive CD8+ T cell responses targeting chromogranin A in humanized NOD mice and type 1 diabetes patients

2015 ◽  
Vol 159 (1) ◽  
pp. 63-71 ◽  
Author(s):  
Yi Li ◽  
Lina Zhou ◽  
Yashu Li ◽  
Jie Zhang ◽  
Binbin Guo ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Chromogranin A ◽  
Nod Mice ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses ◽  
Diabetes Patients

scholarly journals The Frequency and Immunodominance of Islet-Specific CD8+ T-cell Responses Change after Type 1 Diabetes Diagnosis and Treatment

Diabetes ◽  
2008 ◽  
Vol 57 (5) ◽  
pp. 1312-1320 ◽  
Author(s):  
E. Martinuzzi ◽  
G. Novelli ◽  
M. Scotto ◽  
P. Blancou ◽  
J.-M. Bach ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Diagnosis And Treatment ◽  
Diabetes Diagnosis ◽  
Cell Responses

Perforin facilitates beta cell killing and regulates autoreactive CD8 + T‐cell responses to antigen in mouse models of type 1 diabetes

2015 ◽  
Vol 94 (4) ◽  
pp. 334-341 ◽  
Author(s):  
Prerak Trivedi ◽  
Kate L Graham ◽  
Balasubramaninan Krishnamurthy ◽  
Stacey Fynch ◽  
Robyn M Slattery ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Beta Cell ◽  
Mouse Models ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Killing ◽  
Cell Responses

Measurement of CD8+T Cell Responses in Human Type 1 Diabetes

2008 ◽  
Vol 1150 (1) ◽  
pp. 61-67 ◽  
Author(s):  
Emanuela Martinuzzi ◽  
François A. Lemonnier ◽  
Christian Boitard ◽  
Roberto Mallone
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses ◽  
Human Type ◽  
Human Type 1 Diabetes

scholarly journals Unmasking Genes in a Type 1 Diabetes-Resistant Mouse Strain That Enhances Pathogenic CD8 T-Cell Responses

Diabetes ◽  
2011 ◽  
Vol 60 (4) ◽  
pp. 1354-1359
Author(s):  
J. P. Driver ◽  
Y.-G. Chen ◽  
W. Zhang ◽  
S. Asrat ◽  
D. V. Serreze
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Mouse Strain ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Resistant Mouse ◽  
Cell Responses ◽  
Resistant Mouse Strain

Rituximab Transiently Affects Islet-specific T Cell Responses in Type 1 Diabetes Patients

2010 ◽  
Vol 135 ◽  
pp. S97
Author(s):  
Barbara Brooks-Worrell ◽  
Craig Beam ◽  
Jessica Reichow ◽  
Jerry Palmer
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
T Cell Responses ◽  
Cell Responses ◽  
Diabetes Patients

scholarly journals Multipeptide-coupled nanoparticles induce tolerance in ‘humanised’ HLA-transgenic mice and inhibit diabetogenic CD8+ T cell responses in type 1 diabetes

Diabetologia ◽  
2017 ◽  
Vol 60 (12) ◽  
pp. 2418-2431 ◽  
Author(s):  
Xinyu Xu ◽  
Lingling Bian ◽  
Min Shen ◽  
Xin Li ◽  
Jing Zhu ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Transgenic Mice ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses

scholarly journals CD8+ T-Cell Responses Identify  -Cell Autoimmunity in Human Type 1 Diabetes

Diabetes ◽  
2007 ◽  
Vol 56 (3) ◽  
pp. 613-621 ◽  
Author(s):  
R. Mallone ◽  
E. Martinuzzi ◽  
P. Blancou ◽  
G. Novelli ◽  
G. Afonso ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses ◽  
Human Type ◽  
Human Type 1 Diabetes

scholarly journals Extensive Polymorphism and Evidence of Immune Selection in a Highly Dominant Antigen Recognized by Bovine CD8 T Cells Specific for Theileria annulata

2011 ◽  
Vol 79 (5) ◽  
pp. 2059-2069 ◽  
Author(s):  
Niall D. MacHugh ◽  
William Weir ◽  
Alison Burrells ◽  
Regina Lizundia ◽  
Simon P. Graham ◽  
...  
Keyword(s):  
Amino Acid ◽  
T Cell ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Theileria Annulata ◽  
T Cell Epitopes ◽  
Major Histocompatibility Complex Haplotype ◽  
Content Type ◽  
Cell Responses ◽  
Restricted Epitope

ABSTRACTAlthough parasite strain-restricted CD8 T cell responses have been described for several protozoa, the precise role of antigenic variability in immunity is poorly understood. The tick-borne protozoan parasiteTheileria annulatainfects leukocytes and causes an acute, often fatal lymphoproliferative disease in cattle. Building on previous evidence of strain-restricted CD8 T cell responses toT. annulata, this study set out to identify and characterize the variability of the target antigens. Three antigens were identified by screening expressed parasite cDNAs with specific CD8 T cell lines. In cattle expressing the A10 class I major histocompatibility complex haplotype, A10-restricted CD8 T cell responses were shown to be focused entirely on a single dominant epitope in one of these antigens (Ta9). Sequencing of the Ta9 gene from field isolates ofT. annulatademonstrated extensive sequence divergence, resulting in amino acid polymorphism within the A10-restricted epitope and a second A14-restricted epitope. Statistical analysis of the allelic sequences revealed evidence of positive selection for amino acid substitutions within the region encoding the CD8 T cell epitopes. Sequence differences in the A10-restricted epitope were shown to result in differential recognition by individual CD8 T cell clones, while clones also differed in their ability to recognize different alleles. Moreover, the representation of these clonal specificities within the responding CD8 T cell populations differed between animals. As well as providing an explanation for incomplete protection observed after heterologous parasite challenge of vaccinated cattle, these results have important implications for the choice of antigens for the development of novel subunit vaccines.

109-OR: T-Cell Responses to Hybrid Insulin Peptides Precede Type 1 Diabetes Development

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 109-OR
Author(s):  
ANGELA M. MITCHELL ◽  
AIMON ALKANANI ◽  
KRISTEN MCDANIEL ◽  
LAURA PYLE ◽  
KATHLEEN WAUGH ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
T Cell Responses ◽  
Cell Responses ◽  
Diabetes Development
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