Perforin facilitates beta cell killing and regulates autoreactive CD8 + T‐cell responses to antigen in mouse models of type 1 diabetes

2015 ◽  
Vol 94 (4) ◽  
pp. 334-341 ◽  
Author(s):  
Prerak Trivedi ◽  
Kate L Graham ◽  
Balasubramaninan Krishnamurthy ◽  
Stacey Fynch ◽  
Robyn M Slattery ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Beta Cell ◽  
Mouse Models ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Killing ◽  
Cell Responses

scholarly journals The Frequency and Immunodominance of Islet-Specific CD8+ T-cell Responses Change after Type 1 Diabetes Diagnosis and Treatment

Diabetes ◽  
2008 ◽  
Vol 57 (5) ◽  
pp. 1312-1320 ◽  
Author(s):  
E. Martinuzzi ◽  
G. Novelli ◽  
M. Scotto ◽  
P. Blancou ◽  
J.-M. Bach ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Diagnosis And Treatment ◽  
Diabetes Diagnosis ◽  
Cell Responses

Measurement of CD8+T Cell Responses in Human Type 1 Diabetes

2008 ◽  
Vol 1150 (1) ◽  
pp. 61-67 ◽  
Author(s):  
Emanuela Martinuzzi ◽  
François A. Lemonnier ◽  
Christian Boitard ◽  
Roberto Mallone
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses ◽  
Human Type ◽  
Human Type 1 Diabetes

scholarly journals Identification of autoreactive CD8+ T cell responses targeting chromogranin A in humanized NOD mice and type 1 diabetes patients

2015 ◽  
Vol 159 (1) ◽  
pp. 63-71 ◽  
Author(s):  
Yi Li ◽  
Lina Zhou ◽  
Yashu Li ◽  
Jie Zhang ◽  
Binbin Guo ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Chromogranin A ◽  
Nod Mice ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses ◽  
Diabetes Patients

scholarly journals Unmasking Genes in a Type 1 Diabetes-Resistant Mouse Strain That Enhances Pathogenic CD8 T-Cell Responses

Diabetes ◽  
2011 ◽  
Vol 60 (4) ◽  
pp. 1354-1359
Author(s):  
J. P. Driver ◽  
Y.-G. Chen ◽  
W. Zhang ◽  
S. Asrat ◽  
D. V. Serreze
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Mouse Strain ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Resistant Mouse ◽  
Cell Responses ◽  
Resistant Mouse Strain

scholarly journals Elevated CD8 T cell responses in type 1 diabetes patients to a 13 amino acid coeliac-active peptide from α-gliadin

2014 ◽  
Vol 175 (2) ◽  
pp. 167-171 ◽  
Author(s):  
W. E. Barbeau ◽  
R. Hontecillas ◽  
W. Horne ◽  
A. Carbo ◽  
M. H. Koch ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Amino Acid ◽  
T Cell ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Active Peptide ◽  
Cell Responses ◽  
Diabetes Patients

scholarly journals Multipeptide-coupled nanoparticles induce tolerance in ‘humanised’ HLA-transgenic mice and inhibit diabetogenic CD8+ T cell responses in type 1 diabetes

Diabetologia ◽  
2017 ◽  
Vol 60 (12) ◽  
pp. 2418-2431 ◽  
Author(s):  
Xinyu Xu ◽  
Lingling Bian ◽  
Min Shen ◽  
Xin Li ◽  
Jing Zhu ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
Transgenic Mice ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses

scholarly journals CD8+ T-Cell Responses Identify  -Cell Autoimmunity in Human Type 1 Diabetes

Diabetes ◽  
2007 ◽  
Vol 56 (3) ◽  
pp. 613-621 ◽  
Author(s):  
R. Mallone ◽  
E. Martinuzzi ◽  
P. Blancou ◽  
G. Novelli ◽  
G. Afonso ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cell Responses ◽  
Human Type ◽  
Human Type 1 Diabetes

109-OR: T-Cell Responses to Hybrid Insulin Peptides Precede Type 1 Diabetes Development

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 109-OR
Author(s):  
ANGELA M. MITCHELL ◽  
AIMON ALKANANI ◽  
KRISTEN MCDANIEL ◽  
LAURA PYLE ◽  
KATHLEEN WAUGH ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
T Cell Responses ◽  
Cell Responses ◽  
Diabetes Development

scholarly journals IFN-γ and IL-10 islet-antigen-specific T cell responses in autoantibody-negative first-degree relatives of patients with type 1 diabetes

Diabetologia ◽  
2010 ◽  
Vol 53 (7) ◽  
pp. 1451-1460 ◽  
Author(s):  
L. G. Petrich de Marquesini ◽  
J. Fu ◽  
K. J. Connor ◽  
A. J. Bishop ◽  
N. E. McLintock ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
T Cell ◽  
T Cell Responses ◽  
Cell Responses ◽  
First Degree Relatives ◽  
Ifn Γ ◽  
Islet Antigen

scholarly journals Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial

PLoS Medicine ◽  
2016 ◽  
Vol 13 (10) ◽  
pp. e1002139 ◽  
Author(s):  
John A. Todd ◽  
Marina Evangelou ◽  
Antony J. Cutler ◽  
Marcin L. Pekalski ◽  
Neil M. Walker ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Single Dose ◽  
T Cell ◽  
Regulatory T Cell ◽  
Interleukin 2 ◽  
T Cell Responses ◽  
Dose Finding ◽  
Open Label ◽  
Cell Responses
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