scholarly journals Fatty acids modulate cytokine and chemokine secretion of stimulated human whole blood cultures in diabetes

2013 ◽  
Vol 172 (3) ◽  
pp. 383-393 ◽  
Author(s):  
M. C. Simon ◽  
S. Bilan ◽  
B. Nowotny ◽  
T. Dickhaus ◽  
V. Burkart ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Whole Blood ◽  
Blood Cultures ◽  
Human Whole Blood

Inflammatory Activity as an Indicator of Water Quality: The use of human whole blood cultures

2000 ◽  
Vol 21 (4) ◽  
pp. 387-399 ◽  
Author(s):  
Edmund J. Pool ◽  
Johannes H. van Wyk ◽  
Alison J. Leslie
Keyword(s):  
Water Quality ◽  
Whole Blood ◽  
Blood Cultures ◽  
Inflammatory Activity ◽  
Human Whole Blood

scholarly journals Interleukin‐18 Enhances Lipopolysaccharide‐Induced Interferon‐γ Production in Human Whole Blood Cultures

1998 ◽  
Vol 178 (6) ◽  
pp. 1830-1834 ◽  
Author(s):  
Adrian J. Puren ◽  
Peter Razeghi ◽  
Giamila Fantuzzi ◽  
Charles A. Dinarello
Keyword(s):  
Whole Blood ◽  
Interferon Γ ◽  
Blood Cultures ◽  
Interleukin 18 ◽  
Human Whole Blood

Procoagulant Activity and Cytokine Expression in Whole Blood Cultures from Patients with Atherosclerosis Supplemented with Omega-3 Fatty Acids

1999 ◽  
Vol 81 (04) ◽  
pp. 566-570 ◽  
Author(s):  
Ingebjørg Seljeflot ◽  
Odd Johansen ◽  
Harald Arnesen ◽  
Jan-Bertil Eggesbø ◽  
Åse-Britt Westvik ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Whole Blood ◽  
Inflammatory Responses ◽  
Cytokine Expression ◽  
Blood Cultures ◽  
Procoagulant Activity ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Group I ◽  
Group Ii

SummaryOmega-3 fatty acids (n-3 FA) may reduce atherogenesis and thrombosis. We investigated the effects of n-3 FAs on procoagulant activity and cytokine expression in whole blood cultures from patients with atherosclerosis. Eleven of the 23 included patients had received 5.1 g n-3 FA daily for 6 months (group I) whereas 12 patients had been on placebo (group II). All patients were then given 5.1g n-3 FA daily for another 4 weeks.At baseline significantly lower levels of LPS-induced prothrombin fragment1+2 were found in group I (p = 0.010), this difference being eliminated after 4 weeks. Il-6 and TNFαwere significantly higher at baseline in group I and the differences in changes from baseline between the groups were statistically highly significant with increasing values in group II (Il-6 p = 0.001, TNFαp = 0.002).The present results indicate a reduction in pro-thrombotic potential in patients receiving highly concentrated n-3 FA, whereas some pro-inflammatory responses might be adverse.

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