Irreversible blindness in generalized eruptive keratoacanthoma of Grzybowski

2021 ◽  
Author(s):  
L. Q. Liu ◽  
T. Jiao ◽  
J. Y. Wang
Keyword(s):  
Irreversible Blindness

scholarly journals Irreversible Blindness Following Intravenous Streptokinase

2013 ◽  
Vol 131 (10) ◽  
pp. 1368 ◽  
Author(s):  
Mohammadreza Peyman ◽  
Visvaraja Subrayan
Keyword(s):  
Intravenous Streptokinase ◽  
Irreversible Blindness

scholarly journals Oxidative stress and antioxidants in the trabecular meshwork

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e8121 ◽  
Author(s):  
Mingxuan Wang ◽  
Yajuan Zheng
Keyword(s):  
Oxidative Stress ◽  
Trabecular Meshwork ◽  
Noncoding Rnas ◽  
Treatment Strategies ◽  
Stress Alleviation ◽  
New Targets ◽  
Age Dependent ◽  
Exogenous Compounds ◽  
Irreversible Blindness

Glaucoma is an age-dependent disease closely related to oxidative stress and is regarded as the second leading cause of irreversible blindness worldwide. In recent years, many studies have shown that morphological and functional abnormalities of the trabecular meshwork (TM) are closely related to glaucoma, especially with respect to oxidative stress. In this review, the mechanisms of oxidative stress in the TM and treatment strategies for this condition, including strategies involving antioxidants, noncoding RNAs and exogenous compounds, are discussed. Although many questions remain to be answered, the reviewed findings provide insights for further research on oxidative stress alleviation in glaucoma and suggest new targets for glaucoma prevention.

Bilateral irreversible blindness in leukaemic meningitis: cause or cure?

2011 ◽  
Vol 90 (12) ◽  
pp. 1487-1488 ◽  
Author(s):  
Christos Tziotzios ◽  
George Follows ◽  
Nicholas Sarkies ◽  
Charles Crawley
Keyword(s):  
Irreversible Blindness

scholarly journals Steroid-induced Glaucoma: An Avoidable Irreversible Blindness

2017 ◽  
Vol 11 (2) ◽  
pp. 67-72 ◽  
Author(s):  
SS Pandav ◽  
Savleen Kaur ◽  
Sushmita Kaushik ◽  
Sonia Phulke
Keyword(s):  
Intraocular Pressure ◽  
Side Effects ◽  
Ocular Hypertension ◽  
Chronic Administration ◽  
Systemic Steroid ◽  
Over The Counter ◽  
Ocular Side ◽  
Inflammatory Drugs ◽  
Irreversible Blindness

ABSTRACT Steroids are a group of anti-inflammatory drugs, commonly used to treat ocular and systemic conditions. Unmonitored use of steroids especially in eye drop formulations is common in situations when it is easily available over-the-counter, resulting in undesirable side effects. Among the ocular side effects, cataract and glaucoma are common. Steroid-induced ocular hypertension was reported in 1950, when long-term use of systemic steroid was shown to increase the intraocular pressure (IOP). Chronic administration of steroids in any form with raised IOP can cause optic neuropathy resulting in steroid-induced glaucoma. This review describes the pathophysiology and epidemio­logy of steroid-induced glaucoma, recognition of side effects, and principles of management. The purpose is to familiarize all clinicians with the potential dangers of administering steroids without monitoring the eye and the dangers of irreversible blindness in some instances of habitual self-prescription by patients. How to cite this article Phulke S, Kaushik S, Kaur S, Pandav SS. Steroid-induced Glaucoma: An Avoidable Irreversible Blindness. J Curr Glaucoma Pract 2017;11(2):67-72.

scholarly journals De novo genesis of retinal ganglion cells by targeted expression of KLF4 in vivo

2018 ◽  
Author(s):  
Maurício Rocha-Martins ◽  
Beatriz C. de Toledo ◽  
Pedro L. Santos-França ◽  
Viviane M. Oliveira-Valença ◽  
Carlos H. Vieira-Vieira ◽  
...  
Keyword(s):  
Ganglion Cell ◽  
Progenitor Cells ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Müller Cells ◽  
Therapeutic Strategies ◽  
Retinal Ganglion ◽  
Promising Tool ◽  
Irreversible Blindness

AbstractRetinal ganglion cell (RGC) degeneration is a hallmark of glaucoma, the most prevalent cause of irreversible blindness. Thus, innovative therapeutic strategies are needed to protect and replace these projection neurons. It has been shown that endogenous glial cells of the retina, Müller cells, can be directly reprogrammed into late-born retinal interneurons. However, since RGCs are the first neurons born during development, the replacement of damaged RGCs requires the reprograming to an early neurogenic state. Here, we demonstrate that the pluripotency regulator Klf4 is sufficient to reprogram the potency of lineage-restricted retinal progenitor cells (RPCs) to generate RGCs in vivo. Transcriptome analysis disclosed that the overexpression of Klf4 induces crucial regulators of RGC competence and specification, including Atoh7 and Eya2. In contrast, loss-of-function studies in mice and zebrafish demonstrated that Klf4 is not essential for generation or differentiation of RGCs during retinogenesis. Nevertheless, induced RGCs (iRGCs) generated upon Klf4 overexpression migrate to the proper layer and project axons aligned with endogenous fascicles that reach the optic nerve head. Notably, iRGCs survive for up to 30 days after in vivo reprogramming. Finally, we demonstrate that Klf4 converts Müller cells into neurons that express markers of RGCs. Altogether, we identified Klf4 as a promising tool to reprogram retinal cells and regenerate RGCs in the mature retina.Significance StatementCell fate determination is a key process for development, regeneration and for the design of therapeutic strategies that involve cellular reprogramming. This work shows that the manipulation of a single pluripotency regulator (Klf4) is sufficient to reprogram restricted progenitor cells in vivo. These reprogrammed progenitors reacquire the potency to generate retinal ganglion cells. Ganglion cell degeneration is the leading cause of irreversible blindness; therefore, manipulation of ganglion cell competence is of relevance for human health. Our findings point to Klf4 as a promising tool to develop therapeutic strategies for the replacement of damaged ganglion cells.

scholarly journals Biomechanical research into lamina cribrosa in glaucoma

2020 ◽  
Vol 7 (8) ◽  
pp. 1277-1279
Author(s):  
Long Li ◽  
Fan Song
Keyword(s):  
Public Health ◽  
Intraocular Pressure ◽  
Lamina Cribrosa ◽  
Health Challenge ◽  
Elevated Intraocular Pressure ◽  
Mechanical Models ◽  
Public Health Challenge ◽  
Further Development ◽  
Open Issues ◽  
Irreversible Blindness

Summary Glaucoma, a leading cause of irreversible blindness, poses a considerable public health challenge and burden. Mechanical models of the lamina cribrosa under elevated intraocular pressure at different scales, contributing significantly to uncovering the glaucomatous pathogenesis, are discussed. Meanwhile, the open issues and avenues for further development are highlighted.

Blindness due to electrocoagulation following functional endoscopic sinus surgery

1996 ◽  
Vol 110 (3) ◽  
pp. 261-264 ◽  
Author(s):  
D. Vanden Abeele ◽  
A. Clemens ◽  
M. J. Tassignon ◽  
P. H. van de Heyning
Keyword(s):  
Visual Field ◽  
Endoscopic Sinus Surgery ◽  
Recent Literature ◽  
Rare Complication ◽  
Functional Endoscopic Sinus Surgery ◽  
The Other ◽  
Sinus Surgery ◽  
Delayed Bleeding ◽  
Irreversible Blindness

AbstractA case is presented with irreversible blindness in one eye and restriction of the infratemporal visual field in the other eye, due to electrocoagulation performed for delayed bleeding after functional endoscopic sinus surgery (FESS). Although blindness due to rhinosurgery is a well-known, but rare complication, a review of the recent literature did not reveal a similar incident. The use of electrocoagulation especially under conditions of poor visualization, that may be the case in post-operative bleeding following (endoscopic) sinus surgery, is strongly discouraged.

scholarly journals Current understanding of Age-related macular degeneration

2020 ◽  
Vol 3 (2) ◽  
Author(s):  
Swathi Kanduri ◽  
Monica Liliana Acosta ◽  
Trevor Sherwin ◽  
Charles Ninian John McGhee ◽  
Colin R Green
Keyword(s):  
Macular Degeneration ◽  
Elderly Population ◽  
The Elderly ◽  
Developed Countries ◽  
Age Related Macular Degeneration ◽  
Current Understanding ◽  
Therapeutic Approaches ◽  
Age Related ◽  
The Developed Countries ◽  
Irreversible Blindness

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in the elderly population 50 years of age or older in the developed countries. This review discusses the traditional clinical and histopathological presentation of AMD, epidemiology and genetics component in relation to the current understanding of the vascular nature of the disease. Therapeutic approaches to treat the disease are also included in the review.

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