A prickly souvenir from a hedgehog café: tinea manuum secondary to Trichophyton erinacei via international spread

2020 ◽  
Vol 45 (4) ◽  
pp. 459-461
Author(s):  
M. De Brito ◽  
C. Halliday ◽  
B. Dutta ◽  
E. Fanning ◽  
S. Kossard ◽  
...  
Keyword(s):  
Trichophyton Erinacei

Trichophyton erinacei Transmitted to a Pregnant Woman From Her Pet Hedgehogs

2018 ◽  
Vol 154 (8) ◽  
pp. 967 ◽  
Author(s):  
Christian Kromer ◽  
Pietro Nenoff ◽  
Silke Uhrlaß ◽  
Antje Apel ◽  
Michael Peter Schön ◽  
...  
Keyword(s):  
Pregnant Woman ◽  
Trichophyton Erinacei

scholarly journals European Hedgehogs (Erinaceus europaeus L.) as a Reservoir of Dermatophytes in Poland

2021 ◽  
Author(s):  
Sebastian Gnat ◽  
Dominik Łagowski ◽  
Mariusz Dyląg ◽  
Aneta Nowakiewicz
Keyword(s):  
Human Life ◽  
Primary Source ◽  
Trichophyton Mentagrophytes ◽  
Antifungal Drugs ◽  
Microsporum Canis ◽  
Missense Mutations ◽  
Erinaceus Europaeus ◽  
Trichophyton Erinacei ◽  
Trichophyton Benhamiae ◽  
European Hedgehog

AbstractThe European hedgehog (Erinaceus europaeus Linnaeus) frequently colonises areas located close to human life in cities, as these are more suitable nest sites offering an abundance of food and allowing avoidance of predators. However, urbanisation has a significant impact on the epidemiology of infectious diseases, including dermatophytoses, the primary source of which are wild animals. In this study, we determined the spectrum of dermatophytes isolated from the European hedgehog and assessed their susceptibility profile to antifungal drugs. Symptomatic and asymptomatic dermatophyte infections were observed in 7.7% and 8% of the 182 examined free-living hedgehogs, respectively. In the pool of the isolated dermatophyte strains, Trichophyton erinacei was dominant (29.9%), followed by Trichophyton mentagrophytes (17.9%), Trichophyton benhamiae (13.4%), Nannizzia gypsea (11.9%), Microsporum canis (10.4%), Nannizzia nana (7.5%), Paraphyton cookei (6.0%), and Nannizzia fulva (3.0%). Susceptibility tests revealed the highest activity of luliconazole and the lowest of activity fluconazole among the azole drugs applied. Although terbinafine generally exhibited high efficacy, two Trichophyton mentagrophytes isolates showed resistance to this drug (MIC = 2 µg/ml) resulting from missense mutations in the SQLE gene corresponding to the amino acid substitution Leu393Phe. Summarising, our study has also revealed that such wildlife animals as hedgehogs can be a reservoir of pathogenic human dermatophytes, including harmful strains resistant to commonly used antifungal drugs. Graphical Abstract

scholarly journals Emergence of methicillin resistance predates the clinical use of antibiotics

Nature ◽  
2022 ◽  
Author(s):  
Jesper Larsen ◽  
Claire L. Raisen ◽  
Xiaoliang Ba ◽  
Nicholas J. Sadgrove ◽  
Guillermo F. Padilla-González ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Methicillin Resistance ◽  
Animal Health ◽  
Antibiotic Resistance Genes ◽  
Clinical Use ◽  
Human Pathogens ◽  
Health Food ◽  
Methicillin Resistant ◽  
Trichophyton Erinacei ◽  
Human Ecosystems

AbstractThe discovery of antibiotics more than 80 years ago has led to considerable improvements in human and animal health. Although antibiotic resistance in environmental bacteria is ancient, resistance in human pathogens is thought to be a modern phenomenon that is driven by the clinical use of antibiotics1. Here we show that particular lineages of methicillin-resistant Staphylococcus aureus—a notorious human pathogen—appeared in European hedgehogs in the pre-antibiotic era. Subsequently, these lineages spread within the local hedgehog populations and between hedgehogs and secondary hosts, including livestock and humans. We also demonstrate that the hedgehog dermatophyte Trichophyton erinacei produces two β-lactam antibiotics that provide a natural selective environment in which methicillin-resistant S. aureus isolates have an advantage over susceptible isolates. Together, these results suggest that methicillin resistance emerged in the pre-antibiotic era as a co-evolutionary adaptation of S. aureus to the colonization of dermatophyte-infected hedgehogs. The evolution of clinically relevant antibiotic-resistance genes in wild animals and the connectivity of natural, agricultural and human ecosystems demonstrate that the use of a One Health approach is critical for our understanding and management of antibiotic resistance, which is one of the biggest threats to global health, food security and development.

scholarly journals Pustular tinea manuum from Trichophyton erinacei infection

2018 ◽  
Vol 4 (6) ◽  
pp. 518-520 ◽  
Author(s):  
Ellie Choi ◽  
Jingxiang Huang ◽  
Ka Lip Chew ◽  
Huma Jaffar ◽  
Chris Tan
Keyword(s):  
Trichophyton Erinacei

scholarly journals Trichophyton erinacei Onychomycosis: The First to Evidence a Proximal Subungual Onychomycosis Pattern

2019 ◽  
Vol 11 (2) ◽  
pp. 198-203 ◽  
Author(s):  
Sutasinee Phaitoonwattanakij ◽  
Charussri Leeyaphan ◽  
Sumanus Bunyaratavej ◽  
Kittipoom Chinhiran
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Decision Making ◽  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Drug Susceptibility ◽  
Mycological Cure ◽  
Drug Susceptibility Test ◽  
Systemic Lupus ◽  
Trichophyton Erinacei ◽  
History Of

Trichophyton erinacei is an emerging cause of dermatophyte infections, which are frequently isolated from hedgehogs. Nail infections from T. erinacei are rarely reported. We describe the case of a 23-year-old Thai female who had a history of systemic lupus erythematosus with lupus nephritis type III and who developed widespread skin and nail infections caused by T. erinacei that were most likely transmitted from a hedgehog. Although the patient did not demonstrate a clinical improvement or mycological cure following systemic itraconazole and fluconazole treatment, she achieved clinical and mycological cures after terbinafine therapy. A drug susceptibility test should be performed in patients with T. erinacei infections to facilitate decision-making about antifungal therapy. Here, we are the first to report a case of proximal subungual onychomycosis from a T. erinacei infection.

Dermatophytes à Trichophyton erinacei  : à propos d’un cas

2013 ◽  
Vol 23 (3) ◽  
pp. 206
Author(s):  
M. Bouchekoua ◽  
K. Dridi ◽  
S. Trabelsi ◽  
S. Khaled
Keyword(s):  
Trichophyton Erinacei

Kerion celsi caused by Trichophyton erinacei from a hedgehog treated with terbinafine

2016 ◽  
Vol 44 (9) ◽  
pp. 1070-1071 ◽  
Author(s):  
Min Soo Jang ◽  
Jong Bin Park ◽  
Ji Yun Jang ◽  
Myeong Hyeon Yang ◽  
Joon Hee Kim ◽  
...  
Keyword(s):  
Kerion Celsi ◽  
Trichophyton Erinacei

scholarly journals Benzylpenicillin-producing Trichophyton erinacei and methicillin resistant Staphylococcus aureus carrying the mecC gene on European hedgehogs – A pilot-study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Faruk Dube ◽  
Robert Söderlund ◽  
Matilda Lampinen Salomonsson ◽  
Karin Troell ◽  
Stefan Börjesson
Keyword(s):  
Staphylococcus Aureus ◽  
Pilot Study ◽  
High Performance ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Carriage Rate ◽  
Benzyl Penicillin ◽  
Methicillin Resistant ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Trichophyton Erinacei

Abstract Background A high carriage rate of methicillin-resistant Staphylococcus aureus with the mecC gene (mecC-MRSA) has been described among Wild European hedgehogs (Europeaus erineaus). Due to this frequent occurrence, it has been suggested that hedgehogs could be a natural reservoir for mecC-MRSA. However, the reason why hedgehogs carry mecC-MRSA remains unknown, but it has been hypothesized that mecC-MRSA could have evolved on the skin of hedgehogs due to the co-occurrence with antibiotic producing dermatophytes. The aim of this pilot-study was therefore to investigate if hedgehogs in Sweden carry Trichophyton spp. and to provide evidence that these dermatophytes are able to produce penicillin or similar substances. In addition, the study aimed to identify if dermatophytes co-occurred with mecC-MRSA. Methods Samples were collected from hedgehogs (Europeaus erineaus) that were euthanized or died of natural causes. All samples were screened for dermatophytes and mecC-MRSA using selective cultivation methods. Suspected isolates were characterized using PCR-based methods, genome sequencing and bioinformatic analyses. Identification of penicillin was performed by ultra-high-performance liquid chromatography-tandem mass spectrometry. Results In total 23 hedgehogs were investigated, and it was shown that two carried Trichophyton erinacei producing benzyl-penicillin, and that these hedgehogs also carried mecC-MRSA. The study also showed that 60% of the hedgehogs carried mecC-MRSA. Conclusion The pilot-study demonstrated that Trichophyton erinacei, isolated from Swedish hedgehogs, can produce benzylpenicillin and that these benzylpenicillin-producing T. erinacei co-occurred with mecC-MRSA. The study also reconfirmed the high occurrence of mecC-MRSA among hedgehogs.

scholarly journals Detection and Control of Dermatophytosis in Wild European Hedgehogs (Erinaceus europaeus) Admitted to a French Wildlife Rehabilitation Centre

2021 ◽  
Vol 7 (2) ◽  
pp. 74
Author(s):  
Cécile Le Barzic ◽  
Adela Cmokova ◽  
Chloé Denaes ◽  
Pascal Arné ◽  
Vit Hubka ◽  
...  
Keyword(s):  
Trichophyton Mentagrophytes ◽  
Skin Lesions ◽  
Fungal Culture ◽  
Prevention Measures ◽  
Rehabilitation Centre ◽  
Erinaceus Europaeus ◽  
Asymptomatic Carriers ◽  
Wildlife Rehabilitation ◽  
Trichophyton Erinacei ◽  
And Control

The rising number of European hedgehogs (Erinaceus europaeus) admitted every year to wildlife rehabilitation centres might be a source of concern to animal and public health since transmissible diseases, such as dermatophytosis, can be easily disseminated. This study seeks to evaluate the frequency of dermatophyte detection in hedgehogs admitted to a wildlife rehabilitation centre located near Paris, France, and to assess the risk of contamination in the centre in order to adapt prevention measures. A longitudinal cohort study was performed on 412 hedgehogs hosted at the Wildlife Animal Hospital of the Veterinary College of Alfort from January to December 2016. Animals were sampled once a month for fungal culture. Dermatophyte colonies were obtained from 174 out of 686 skin samples (25.4%). Besides Trichophyton erinacei, Trichophyton mentagrophytes and Nannizzia gypsea were also found. Dermatophyte detection seemed to be associated with the presence of skin lesions, while more than one-third of T. erinacei-positive animals were asymptomatic carriers. Healing required several months of treatment with topical and systemic azoles, but dermatophytosis did not seem to reduce the probability of release. Daily disinfection procedures and early detection and treatment of infected and asymptomatic carriers succeeded in limiting dermatophyte transmission between hedgehogs and humans.

scholarly journals Inflammatory Tinea Manuum due to <i>Trichophyton erinacei</i> from an African Hedgehog

2018 ◽  
Vol 08 (12) ◽  
pp. 1021-1028
Author(s):  
Coronado-Aguilar Alejandra ◽  
Perez-Olivos Mirta de Lourdes ◽  
Mayorga-Garibaldi Jorge Leonardo ◽  
Mayorga-Rodríguez Jorge ◽  
Córdova-Martínez Erika ◽  
...  
Keyword(s):  
Trichophyton Erinacei
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