scholarly journals The association of maternal folic acid supplementation and prenatal folate and vitamin B12 concentrations with child dental development

2021 ◽  
Author(s):  
Brunilda Dhamo ◽  
Vincent W. V. Jaddoe ◽  
Eric A. P. Steegers ◽  
Eppo B. Wolvius ◽  
Edwin M. Ongkosuwito
Keyword(s):  
Folic Acid ◽  
Vitamin B12 ◽  
Folic Acid Supplementation ◽  
Dental Development ◽  
Acid Supplementation ◽  
Folate And Vitamin B12

Effects of 2-year vitamin B12 and folic acid supplementation in hyperhomocysteinemic elderly on arterial stiffness and cardiovascular outcomes within the B-PROOF trial

2015 ◽  
Vol 33 (9) ◽  
pp. 1897-1906 ◽  
Author(s):  
Suzanne C. van Dijk ◽  
Anke W. Enneman ◽  
Karin M.A. Swart ◽  
Janneke P. van Wijngaarden ◽  
Annelies C. Ham ◽  
...  
Keyword(s):  
Folic Acid ◽  
Arterial Stiffness ◽  
Vitamin B12 ◽  
Folic Acid Supplementation ◽  
Cardiovascular Outcomes ◽  
Acid Supplementation

scholarly journals Effect of vitamin B12 and folic acid supplementation on biomarkers of endothelial function and inflammation among elderly individuals with hyperhomocysteinemia

2016 ◽  
Vol 21 (2) ◽  
pp. 91-98 ◽  
Author(s):  
Suzanne C van Dijk ◽  
Anke W Enneman ◽  
Karin MA Swart ◽  
Janneke P van Wijngaarden ◽  
Annelies C Ham ◽  
...  
Keyword(s):  
Folic Acid ◽  
Endothelial Function ◽  
Vitamin B12 ◽  
Folic Acid Supplementation ◽  
Elderly Individuals ◽  
Acid Supplementation

Hyperhomocysteinaemia in children receiving phenytoin and carbamazepine monotherapy: a cross-sectional observational study

2016 ◽  
Vol 102 (4) ◽  
pp. 346-351 ◽  
Author(s):  
Saravanan Chandrasekaran ◽  
Sooraj Patil ◽  
Renu Suthar ◽  
Savita Verma Attri ◽  
Jitendra Kumar Sahu ◽  
...  
Keyword(s):  
Folic Acid ◽  
Observational Study ◽  
Vitamin B12 ◽  
Antiepileptic Drug ◽  
Folic Acid Supplementation ◽  
Plasma Homocysteine ◽  
Study Group ◽  
Indian Children ◽  
Cross Sectional ◽  
Acid Supplementation

ObjectiveLong-term therapy with phenytoin and carbamazepine is known to cause hyperhomocysteinaemia. We evaluated the prevalence of hyperhomocysteinaemia in North Indian children receiving phenytoin or carbamazepine monotherapy for >6 months duration and the effect of folic acid supplementation on plasma homocysteine.MethodsIn this cross-sectional observational study we enrolled consecutive children aged 2–12 years with epilepsy who had received phenytoin or carbamazepine monotherapy for >6 months. Plasma total homocysteine, folic acid, vitamin B12 and antiepileptic drug concentrations were measured. Healthy age- and sex-matched controls were recruited. Children with homocysteine >10.4 µmol/L received folic acid supplementation for 1 month and homocysteine and folic acid concentrations were measured after 1 month follow-up.ResultsA total of 112 children receiving antiepileptic monotherapy for >6 months were enrolled. Hyperhomocysteinaemia was present in 54 children (90%) receiving phenytoin, 45 children (90%) receiving carbamazepine therapy and 17 (34%) controls (p<0.05). Mean plasma homocysteine concentrations were significantly higher (18.9±10.2 vs 9.1±3 µmol/L) and serum folic acid concentrations (10.04±8.5 ng/ml vs 12.6±4.8 p<0.001) and vitamin B12 concentrations (365±155 pg/mL vs 474±332 pg/mL, p=0.02) were significantly lower in the study group compared with the control group. Duration of antiepileptic drug therapy correlated significantly with elevated homocysteine and reduced folic acid concentrations (p<0.05). Supplementation with folic acid for 1 month led to a reduction in plasma homocysteine concentrations in the study group (from 20.9±10.3 µmol/L to 14.2±8.2 µmol/L, p<0.05).ConclusionsPhenytoin or carbamazepine monotherapy for >6 months duration is associated with hyperhomocysteinaemia in 90% of North Indian children. Elevated homocysteine concentrations were normalised in these children with folic acid supplementation.

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