Design, synthesis and biological evaluation of N ‐substituted indole‐thiazolidinedione hybrid analogues as potential pancreatic lipase inhibitors

2021 ◽  
Author(s):  
Ginson George ◽  
Prashant S Auti ◽  
Atish T. Paul
Keyword(s):  
Pancreatic Lipase ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Pancreatic Lipase Inhibitors ◽  
Synthesis And Biological Evaluation

Design, synthesis, biological evaluation, and molecular modeling studies of rhodanine derivatives as pancreatic lipase inhibitors

2019 ◽  
Vol 352 (10) ◽  
pp. 1900029 ◽  
Author(s):  
Divya Chauhan ◽  
Ginson George ◽  
S. N. C. Sridhar ◽  
Rohit Bhatia ◽  
Atish T. Paul ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Pancreatic Lipase ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Modeling Studies ◽  
Molecular Modeling Studies ◽  
Pancreatic Lipase Inhibitors

Design, synthesis, biological evaluation and molecular modelling studies of conophylline inspired novel indolyl oxoacetamides as potent pancreatic lipase inhibitors

2020 ◽  
Vol 44 (28) ◽  
pp. 12355-12369
Author(s):  
Sridhar S. N. C. ◽  
Saksham Palawat ◽  
Atish T. Paul
Keyword(s):  
Pancreatic Lipase ◽  
Molecular Modelling ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Molecular Modelling Studies ◽  
Modelling Studies ◽  
Pancreatic Lipase Inhibitors ◽  
Pancreatic Lipase Inhibition ◽  
Lipase Inhibition

Twenty-one indolyl oxoacetamides were designed and synthesized inspired by conophylline. Analogues 12c and 12b with N-geranyl substitution on indole exhibited potent pancreatic lipase inhibition.

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