Design, Synthesis, and Biological Evaluation of Coumarin-Triazole Hybrid Molecules as Potential Antitumor and Pancreatic Lipase Agents

2017 ◽  
Vol 350 (8) ◽  
pp. 1600369 ◽  
Author(s):  
Bahittin Kahveci ◽  
Fatih Yılmaz ◽  
Emre Menteşe ◽  
Serdar Ülker
Keyword(s):  
Pancreatic Lipase ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Hybrid Molecules ◽  
Synthesis And Biological Evaluation ◽  
Potential Antitumor

Design, Synthesis and Biological Evaluation of Hybrid Molecules Containing Conjugated Styryl Ketone and α-Bromoacryloyl Moieties

2012 ◽  
Vol 9 (2) ◽  
pp. 140-152 ◽  
Author(s):  
Romeo Romagnoli ◽  
Pier Giovanni Baraldi ◽  
Olga Cruz-Lopez ◽  
Maria Kimatrai Salvador ◽  
Delia Preti ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Hybrid Molecules ◽  
Synthesis And Biological Evaluation

scholarly journals Design, synthesis and biological evaluation of tryptamine salicylic acid derivatives as potential antitumor agents

MedChemComm ◽  
2019 ◽  
Vol 10 (4) ◽  
pp. 573-583 ◽  
Author(s):  
Runde Xiong ◽  
Dongxiu He ◽  
Xiangping Deng ◽  
Juan Liu ◽  
Xiaoyong Lei ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Salicylic Acid ◽  
Antitumor Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Combination Principle ◽  
Salicylic Acid Derivatives ◽  
Synthesis And Biological Evaluation ◽  
Tumor Agent ◽  
Potential Antitumor

According to the combination principle, target compounds were designed, and compound E20 might be a promising anti-tumor agent targeting gastric cancer.

scholarly journals Design, Synthesis, and Biological Evaluation of Triazolyl- and Triazinyl-Quinazolinediones as Potential Antitumor Agents

2019 ◽  
Vol 2019 ◽  
pp. 1-12
Author(s):  
Abeer N. Al-Romaizan ◽  
Nesreen S. Ahmed ◽  
Sherin M. Elfeky
Keyword(s):  
Antitumor Agents ◽  
Human Colon ◽  
Biological Evaluation ◽  
Human Cell Lines ◽  
Hep G2 ◽  
Design Synthesis ◽  
Reference Drug ◽  
Human Colon Carcinoma ◽  
Synthesis And Biological Evaluation ◽  
Potential Antitumor

Novel 6(3-1H-1,2,4-triazol-1-yl)-3-phenylquinazoline-2,4(1H,3H)-diones (7a–e) were synthesized from different enaminones (6a–e) with 6-hydrazinyl-3-phenylquinazoline-2,4(1H,3H)-dione. 2,6(4-2-Substituted-1,3,5-triazin-1(2H)-yl)-3-phenylquinazoline-2,4(1H,3H)-diones (8a–k) were synthesized from the reaction of 1-(2,4-dioxo-3-phenyl-1,2,3,4-tetrahydroquinazolin-6-yl)thiourea, urea, or guanidine (3a–c) with enaminones (6a–e), and a series from 3-substituted-2-imino-1,3,5-triazin-1(2H)-yl-sulfonyl-phenyl-1-methylquinazoline-2,4(1H,3H)-dione (12a–j) were obtained from the reaction of N-(diaminomethylene)-4-(1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)benzenesulfonamide (11) with the enaminone (6a–j). The antitumor activity of the synthesized compounds was evaluated against two human cell lines: human colon carcinoma HCT116 and human hepatocellular carcinoma HEP-G2. Some of the tested compounds showed significant potency compared to the reference drug staurosporin.

scholarly journals Design, Synthesis and Biological Evaluation of C(6)-Modified Celastrol Derivatives as Potential Antitumor Agents

Molecules ◽  
2014 ◽  
Vol 19 (7) ◽  
pp. 10177-10188 ◽  
Author(s):  
Kaiyong Tang ◽  
Qingqing Huang ◽  
Jafeng Zeng ◽  
Guangming Wu ◽  
Jinwen Huang ◽  
...  
Keyword(s):  
Antitumor Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Potential Antitumor
Sign in / Sign up

Export Citation Format

Share Document