Design of a new pH‐activatable cell‐penetrating peptide for drug delivery into tumor cells

2019 ◽  
Vol 94 (5) ◽  
pp. 1884-1893 ◽  
Author(s):  
Yun Zhang ◽  
Li Li ◽  
Linlin Chang ◽  
Hui Liu ◽  
Jingjing Song ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating

scholarly journals Dimerization of a cell-penetrating peptide leads to enhanced cellular uptake and drug delivery

2012 ◽  
Vol 8 ◽  
pp. 1788-1797 ◽  
Author(s):  
Jan Hoyer ◽  
Ulrich Schatzschneider ◽  
Michaela Schulz-Siegmund ◽  
Ines Neundorf
Keyword(s):  
Drug Delivery ◽  
Tumor Cells ◽  
Cell Lines ◽  
Cellular Uptake ◽  
Cell Penetrating Peptides ◽  
Antimicrobial Protein ◽  
Cell Penetrating Peptide ◽  
Specific Cell ◽  
Cell Penetrating ◽  
A Cell

Over the past 20 years, cell-penetrating peptides (CPPs) have gained tremendous interest due to their ability to deliver a variety of therapeutically active molecules that would otherwise be unable to cross the cellular membrane due to their size or hydrophilicity. Recently, we reported on the identification of a novel CPP, sC18, which is derived from the C-terminus of the 18 kDa cationic antimicrobial protein. Furthermore, we demonstrated successful application of sC18 for the delivery of functionalized cyclopentadienyl manganese tricarbonyl (cymantrene) complexes to tumor cell lines, inducing high cellular toxicity. In order to increase the potential of the organometallic complexes to kill tumor cells, we were looking for a way to enhance cellular uptake. Therefore, we designed a branched dimeric variant of sC18, (sC18)2, which was shown to have a dramatically improved capacity to internalize into various cell lines, even primary cells, using flow cytometry and fluorescence microscopy. Cell viability assays indicated increased cytotoxicity of the dimer presumably caused by membrane leakage; however, this effect turned out to be dependent on the specific cell type. Finally, we could show that conjugation of a functionalized cymantrene with (sC18)2leads to significant reduction of its IC50value in tumor cells compared to the respective sC18 conjugate, proving that dimerization is a useful method to increase the drug-delivery potential of a cell-penetrating peptide.

scholarly journals SPA: a peptide antagonist that acts as a cell-penetrating peptide for drug delivery

Drug Delivery ◽  
2019 ◽  
Vol 27 (1) ◽  
pp. 91-99
Author(s):  
Jingjing Song ◽  
Sujie Huang ◽  
Zhengzheng Zhang ◽  
Bo Jia ◽  
Huan Xie ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating ◽  
A Cell ◽  
Peptide Antagonist

Quantifying molecular partition of cell-penetrating peptide-cargo supramolecular complexes into lipid membranes: optimizing peptide-based drug delivery systems

2013 ◽  
Vol 19 (4) ◽  
pp. 182-189 ◽  
Author(s):  
João Miguel Freire ◽  
Ana Salomé Veiga ◽  
Beatriz G. de la Torre ◽  
David Andreu ◽  
Miguel A. R. B. Castanho
Keyword(s):  
Drug Delivery ◽  
Lipid Membranes ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Supramolecular Complexes ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating

Retracted Article: The next generation cell-penetrating peptide and carbon dot conjugated nano-liposome for transdermal delivery of curcumin

2016 ◽  
Vol 4 (3) ◽  
pp. 418-429 ◽  
Author(s):  
Santanu Patra ◽  
Ekta Roy ◽  
Rashmi Madhuri ◽  
Prashant K. Sharma
Keyword(s):  
Drug Delivery ◽  
Transdermal Delivery ◽  
Transdermal Drug Delivery ◽  
Circulation Time ◽  
Cell Penetrating Peptide ◽  
Next Generation ◽  
Carbon Dot ◽  
Cell Penetrating ◽  
Retracted Article ◽  
Enhanced Stability

Novel polyarginine-conjugated C dot modified spherical nano-liposomes with enhanced stability, long circulation time and high cytocompatibility are successfully prepared and investigated for transdermal drug delivery.

Recentin vivoadvances in cell-penetrating peptide-assisted drug delivery

2015 ◽  
Vol 13 (3) ◽  
pp. 373-387 ◽  
Author(s):  
Kaido Kurrikoff ◽  
Maxime Gestin ◽  
Ülo Langel
Keyword(s):  
Drug Delivery ◽  
Cell Penetrating Peptide ◽  
Cell Penetrating
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