Antitumor effect of palmitic acid‐conjugated Dsi RNA for colon cancer in a mouse subcutaneous tumor model

2019 ◽  
Vol 93 (4) ◽  
pp. 570-581 ◽  
Author(s):  
Takanori Kubo ◽  
Yoshio Nishimura ◽  
Yuta Hatori ◽  
Reiko Akagi ◽  
Keichiro Mihara ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Palmitic Acid ◽  
Antitumor Effect ◽  
Tumor Model ◽  
Subcutaneous Tumor

Antitumor effect of whole body hyperthermia withα-galactosylceramide in a subcutaneous tumor model of colon cancer

2007 ◽  
Vol 23 (7) ◽  
pp. 591-598 ◽  
Author(s):  
Takeshi Hattori ◽  
Satoshi Kokura ◽  
Toshimitsu Okuda ◽  
Tetsuya Okayama ◽  
Tomohisa Takagi ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Antitumor Effect ◽  
Tumor Model ◽  
Whole Body ◽  
Subcutaneous Tumor ◽  
Whole Body Hyperthermia

scholarly journals Murine hepatoma treatment with mature dendritic cells stimulated by Trichinella spiralis excretory/secretory products

Parasite ◽  
2020 ◽  
Vol 27 ◽  
pp. 47
Author(s):  
Jing Ding ◽  
Xiaolei Liu ◽  
Bin Tang ◽  
Xue Bai ◽  
Yang Wang ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Tumor Growth ◽  
Antitumor Effect ◽  
Trichinella Spiralis ◽  
Critical Role ◽  
Tumor Model ◽  
Control Group ◽  
Tumor Inhibition ◽  
Significant Difference ◽  
Secretory Products

Excretory/Secretory Products (ESPs) of the nematode Trichinella spiralis contain antitumor-active substances that inhibit tumor growth. Mature dendritic cells (DCs) play a critical role in the antitumor immunity of the organism. As pathogen-derived products, it ought to be discussed whether T. spiralis ESPs will reduce the antitumor effect of mature DCs from the host before it is applied to patients’ tumors. Therefore, the aim of this work was to evaluate the immunological effect of DCs stimulated by T. spiralis ESPs in H22 tumor-bearing mice. H22 tumor model mice in this study were randomly divided into four groups according to the treatment: PBS control group, ESP group, DCs group, and DCs stimulated with T. spiralis ESP (ESP+DCs group). The antitumor effect was evaluated by tumor inhibition rate and cytokine detection using ELISA. The results showed significant inhibition in tumor growth in the ESP+DCs, DCs and ESP groups when compared with the PBS control group (p < 0.01, p < 0.01, and p < 0.05, respectively). However, no significant difference was observed on tumor inhibition rates between the ESP+DCs and DCs groups. The decrease in IL-4, IL-6, and IL-10, and the increase in IFN-γ between the DCs and ESP+DCs groups were also not significant. Therefore, DCs stimulated by ESP did not reduce the antitumor effect of mature DCs, which demonstrated that the T. spiralis ESP would not affect the antitumor effect of mature DCs by modulating the immune response of the host, and that ESPs are safe in antitumor immunology when applied in a tumor model mice.

An Orthotopic Colon Cancer Model for Studying the B7-H3 Antitumor Effect In Vivo

2006 ◽  
Vol 10 (5) ◽  
pp. 635-645 ◽  
Author(s):  
C LUPU ◽  
C EISENBACH ◽  
M KUEFNER ◽  
J SCHMIDT ◽  
A LUPU ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Antitumor Effect ◽  
Cancer Model

Transarterial Chemoembolization Using Sorafenib in a Rabbit VX2 Liver Tumor Model: Pharmacokinetics and Antitumor Effect

2016 ◽  
Vol 27 (7) ◽  
pp. 1086-1092 ◽  
Author(s):  
Gyoung Min Kim ◽  
Man Deuk Kim ◽  
Do Young Kim ◽  
Se Hoon Kim ◽  
Jong Yun Won ◽  
...  
Keyword(s):  
Liver Tumor ◽  
Transarterial Chemoembolization ◽  
Antitumor Effect ◽  
Tumor Model

Monoclonal antibody 2C5-mediated binding of liposomes to brain tumor cells in vitro and in subcutaneous tumor model in vivo

2005 ◽  
Vol 13 (6) ◽  
pp. 337-343 ◽  
Author(s):  
Bhawna Gupta ◽  
Tatiana S. Levchenko ◽  
Dmitry A. Mongayt ◽  
Vladimir P. Torchilin
Keyword(s):  
Monoclonal Antibody ◽  
Brain Tumor ◽  
Tumor Cells ◽  
Tumor Model ◽  
Subcutaneous Tumor ◽  
Brain Tumor Cells
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