Antibacterial activity and in vivo wound healing potential of phenolic extracts from jaboticaba skin

2018 ◽  
Vol 92 (1) ◽  
pp. 1333-1343 ◽  
Author(s):  
Gustavo Henrique Andrade Machado ◽  
Tamara Rezende Marques ◽  
Thaís Cristina Lima de Carvalho ◽  
André Carvalho Duarte ◽  
Flávia Cíntia de Oliveira ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Phenolic Extracts

scholarly journals In Vivo Study of the Antibacterial Chitosan/Polyvinyl Alcohol Loaded with Silver Nanoparticle Hydrogel for Wound Healing Applications

2019 ◽  
Vol 2019 ◽  
pp. 1-10 ◽  
Author(s):  
Tan Dat Nguyen ◽  
Thanh Truc Nguyen ◽  
Khanh Loan Ly ◽  
Anh Hien Tran ◽  
Thi Thanh Ngoc Nguyen ◽  
...  
Keyword(s):  
Wound Healing ◽  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Polyvinyl Alcohol ◽  
Healing Rate ◽  
Antibacterial Effects ◽  
Topical Gel ◽  
Significant Difference

Silver nanoparticles have attracted great interests widely in medicine due to its great characteristics of antibacterial activity. In this research, the antibacterial activity and biocompatibility of a topical gel synthesized from polyvinyl alcohol, chitosan, and silver nanoparticles were studied. Hydrogels with different concentrations of silver nanoparticles (15 ppm, 30 ppm, and 60 ppm) were evaluated to compare their antibacterial activity, nanoparticles’ sizes, and in vivo behaviors. The resulted silver nanoparticles in the hydrogel were characterized by TEM showing the nanoparticles’ sizes less than 22 nm. The in vitro results prove that the antibacterial effects of all of the samples are satisfied. However, the in vivo results demonstrate the significant difference among different hydrogels in wound healing, where hydrogel with 30 ppm shows the best healing rate.

Antioxidant and wound healing potential of essential oil from Citrus reticulata peel and its chemical characterization. Medicinal values of peels essential oil

2020 ◽  
Vol 21 ◽  
Author(s):  
Maham Ishfaq ◽  
Bushra Akhtar ◽  
Faqir Muhammad ◽  
Ali Sharif ◽  
Muhammad Furqan Akhtar ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Essential Oil ◽  
Chemical Characterization ◽  
Total Flavonoid ◽  
Citrus Reticulata ◽  
Fruit Peel ◽  
Phenolic Contents ◽  
Ms Analysis

Background: Fruit peels are considered as waste and contribute towards a major proportion of biomass. They might be a good source of various therapeutic benefits. Peels biomass of citrus fruits are usually considered as garbage. Such peels may have many important and valuable medicinal components with pharmacological activities. Citrus reticulata, (of family Rutaceae, local name tangerine) is a local seasonal fruit in Pakistan which is a very good example regarding wastage of its peels. Objective: The study is based on exploration of a citrus fruit peel derived essential oil, its chemical characterization, identification of various bioactive components and the exploration of pharmacological potentials (antibacterial and wound healing activity). Method: Essential oil was recovered by hydro-distillation of freshly collected peels. Chemical constituents of oil were determined by gas chromatography-mass spectroscopy (GC-MS) analysis. Antioxidant activities were evaluated by total phenolic contents, total flavonoid content, DPPH scavenging activity and reducing power assay. Antibacterial activity was determined using disc diffusion assay. In vivo wound healing potential was determined in rabbits after topical administration of oil. Wound scoring was calculated followed by histological study. Results: GC-MS analysis showed presence of various components with greatest proportion of D-Limonene (89.31%). Total flavonoid and phenolic contents were found to be 14.63 ± 0.95 mg CE/g and 17.03 ± 3.24 mg GAE/g respectively while DPPH activity was found to be 73.32%. Better antibacterial activity was shown against E. coli. In vivo studies showed significant reduction in wound diameter in essential oil treatment groups. Further the essential oil was found non-irritant in draize scoring. Conclusion: The study concluded that essential oil of this fruit peel might be used for antibacterial and wound healing purposes.

In vivo wound healing and in vitro antioxidant activities of Bletilla striata phenolic extracts

2017 ◽  
Vol 93 ◽  
pp. 451-461 ◽  
Author(s):  
Yi Song ◽  
Rui Zeng ◽  
Lingli Hu ◽  
Katherine G. Maffucci ◽  
Xiaodong Ren ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antioxidant Activities ◽  
Bletilla Striata ◽  
Phenolic Extracts

scholarly journals Allium stipitatumExtract Exhibits In Vivo Antibacterial Activity against Methicillin-ResistantStaphylococcus aureusand Accelerates Burn Wound Healing in a Full-Thickness Murine Burn Model

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Arunkumar Karunanidhi ◽  
Ehsanollah Ghaznavi-Rad ◽  
Jayakayatri Jeevajothi Nathan ◽  
Yusuf Abba ◽  
Alex van Belkum ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Positive Control ◽  
Histopathological Analysis ◽  
Microbiological Analysis ◽  
Burn Wound ◽  
Burn Wound Healing ◽  
Topical Antibacterial ◽  
Thermal Injuries

The in vivo antibacterial and burn wound healing potency of Persian shallot bulbs (Allium stipitatum) were explored in a mice burn model infected with methicillin-resistantStaphylococcus aureus(MRSA). Hexane (ASHE) and dichloromethane (ASDE) extracts were tested. Female BALB/c mice were inflicted with third-degree thermal injury followed by infection with MRSA. ASHE and ASDE formulated with simple ointment base (SOB) at concentrations of 1%, 2%, and 5% (w/w) were topically applied to burn wounds twice a day for 20 days. Silver sulfadiazine (1%) served as drug positive control. Microbiological analysis was carried out on 1, 2, 3, 4, and 5 days postwounding (dpw) and histopathological analysis at the end of the experiment (20 dpw). Both ointments demonstrated strong antibacterial activity with complete elimination of MRSA at 48–72 h after infection. The rate of wound contraction was higher (95–100%) in mice groups treated with ASHE and ASDE ointments after 15 dpw. Histological analysis revealed significant increase (p<0.05) in epithelialization and collagenation in treated groups. The ASHE and ASDE were found to be relatively noncytotoxic and safe to Vero cell line (383.4 μg mL−1; 390.6 μg mL−1), suggesting the extracts as safe topical antibacterial as well as promising alternatives in managing thermal injuries.

Antibacterial activity and in vivo wound healing evaluation of polycaprolactone-gelatin methacryloyl-cephalexin electrospun nanofibrous

2019 ◽  
Vol 256 ◽  
pp. 126618 ◽  
Author(s):  
H.R. Bakhsheshi-Rad ◽  
A.F. Ismail ◽  
M. Aziz ◽  
M. Akbari ◽  
Z. Hadisi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity

In Vivo Wound Healing Activity of Spirulina platensis

2019 ◽  
Vol 18 (1) ◽  
pp. 06-16
Author(s):  
R. Seghiri ◽  
A. Essamri
Keyword(s):  
Wound Healing ◽  
Spirulina Platensis ◽  
Therapeutic Agent ◽  
Conventional Medicine ◽  
Folk Medicine ◽  
Chemical Burns ◽  
Amount Of Substance ◽  
Test Population ◽  
Wound Healing Activity

Spirulina is a microalga used in traditional folk medicine in Morocco for the treatment of various health disorders. The wound healing activity of Moroccan Spirulina is unknown. In the current study, aqueous extracts of Spirulina platensis were investigated for acute toxicity and wound healing activity in Swiss Albino mice and White New Zealand rabbits, respectively. The LD50 (amount of substance required to kill 50% of the test population) of the microalga was greater than 5,000 mg/kg. Healing after application of the same amount of ointment on differently induced (mechanical, chemical, and thermal) wounds was about the same, over five weeks. Aqueous extract had remarkable healing activity on rabbits’ skin, possessing significantly greater healing effect for mechanical and chemical burns than controls. Moreover, the hair growing time was faster in treated groups; Spirulina-treated groups did not show any contamination with microbes compared to others. This study affirms that Spirulina platensis can be considered as a potential therapeutic agent for wound healing not only as a complementary medicine but also in conventional medicine.

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