scholarly journals Design and Synthesis of a Tetrahydroisoquinoline-Based Hydroxamate Derivative (ZYJ-34v), An Oral Active Histone Deacetylase Inhibitor with Potent Antitumor Activity

2013 ◽  
Vol 82 (2) ◽  
pp. 125-130 ◽  
Author(s):  
Yingjie Zhang ◽  
Chunxi Liu ◽  
C. James Chou ◽  
Xuejian Wang ◽  
Yuping Jia ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Design And Synthesis ◽  
Deacetylase Inhibitor

Abstract 4702: Antitumor activity of a novel histone deacetylase inhibitor S78454 in EBV-associated nasopharyngeal carcinoma

2012 ◽  
Author(s):  
Benjamin Verillaud ◽  
Mélanie Gressette ◽  
Marie-Paule Sablin ◽  
Hélène Lelièvre ◽  
Anne Jacquet-Bescond ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Antitumor Activity ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Deacetylase Inhibitor

Discovery of a Potent Class I Selective Ketone Histone Deacetylase Inhibitor with Antitumor Activity in Vivo and Optimized Pharmacokinetic Properties

2009 ◽  
Vol 52 (11) ◽  
pp. 3453-3456 ◽  
Author(s):  
Olaf Kinzel ◽  
Laura Llauger-Bufi ◽  
Giovanna Pescatore ◽  
Michael Rowley ◽  
Carsten Schultz-Fademrecht ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Class I ◽  
Deacetylase Inhibitor ◽  
Pharmacokinetic Properties

Design and Synthesis of a Potent Histone Deacetylase Inhibitor

2007 ◽  
Vol 50 (9) ◽  
pp. 2003-2006 ◽  
Author(s):  
Tao Liu ◽  
Galina Kapustin ◽  
Felicia A. Etzkorn
Keyword(s):  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Design And Synthesis ◽  
Deacetylase Inhibitor

scholarly journals Interferon Regulatory Factor-8 Is Important for Histone Deacetylase Inhibitor-Mediated Antitumor Activity

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e45422 ◽  
Author(s):  
Debarati Banik ◽  
A. Nazmul H. Khan ◽  
Even Walseng ◽  
Brahm H. Segal ◽  
Scott I. Abrams
Keyword(s):  
Antitumor Activity ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Interferon Regulatory Factor ◽  
Regulatory Factor ◽  
Deacetylase Inhibitor

scholarly journals MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo

2008 ◽  
Vol 7 (4) ◽  
pp. 759-768 ◽  
Author(s):  
Marielle Fournel ◽  
Claire Bonfils ◽  
Yu Hou ◽  
Pu Theresa Yan ◽  
Marie-Claude Trachy-Bourget ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Histone Deacetylase ◽  
Broad Spectrum ◽  
Histone Deacetylase Inhibitor ◽  
Deacetylase Inhibitor
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