Discovery of a Potent Class I Selective Ketone Histone Deacetylase Inhibitor with Antitumor Activity in Vivo and Optimized Pharmacokinetic Properties

2009 ◽  
Vol 52 (11) ◽  
pp. 3453-3456 ◽  
Author(s):  
Olaf Kinzel ◽  
Laura Llauger-Bufi ◽  
Giovanna Pescatore ◽  
Michael Rowley ◽  
Carsten Schultz-Fademrecht ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Class I ◽  
Deacetylase Inhibitor ◽  
Pharmacokinetic Properties

scholarly journals MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo

2008 ◽  
Vol 7 (4) ◽  
pp. 759-768 ◽  
Author(s):  
Marielle Fournel ◽  
Claire Bonfils ◽  
Yu Hou ◽  
Pu Theresa Yan ◽  
Marie-Claude Trachy-Bourget ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Histone Deacetylase ◽  
Broad Spectrum ◽  
Histone Deacetylase Inhibitor ◽  
Deacetylase Inhibitor

KD5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo

2008 ◽  
Vol 7 (5) ◽  
pp. 1054-1065 ◽  
Author(s):  
Christian A. Hassig ◽  
Kent T. Symons ◽  
Xin Guo ◽  
Phan-Manh Nguyen ◽  
Tami Annable ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Histone Deacetylase ◽  
Broad Spectrum ◽  
Histone Deacetylase Inhibitor ◽  
Deacetylase Inhibitor
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