scholarly journals Therapeutic and prognostic implications of NOTCH and MAPK signaling in bladder cancer

2021 ◽  
Author(s):  
Gerald B. Schulz ◽  
Sefer Elezkurtaj ◽  
Teresa Börding ◽  
Eva Marina Schmidt ◽  
Manal Elmasry ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Mapk Signaling ◽  
Prognostic Implications

Prognostic implications of lymph node involvement in bladder cancer: are we understaging using current methods?

2011 ◽  
Vol 108 (4) ◽  
pp. 484-492 ◽  
Author(s):  
Kara L. Watts ◽  
Benjamin T. Ristau ◽  
Harold T. Yamase ◽  
John A. Taylor III
Keyword(s):  
Bladder Cancer ◽  
Lymph Node ◽  
Lymph Node Involvement ◽  
Node Involvement ◽  
Prognostic Implications

scholarly journals HnRNP-L mediates bladder cancer progression by inhibiting apoptotic signaling and enhancing MAPK signaling pathways

Oncotarget ◽  
2017 ◽  
Vol 8 (8) ◽  
pp. 13586-13599 ◽  
Author(s):  
Daojun Lv ◽  
Huayan Wu ◽  
Rongwei Xing ◽  
Fangpeng Shu ◽  
Bin Lei ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Signaling Pathways ◽  
Cancer Progression ◽  
Mapk Signaling ◽  
Apoptotic Signaling ◽  
Mapk Signaling Pathways

scholarly journals Unusual Faces of Bladder Cancer

2020 ◽  
Author(s):  
Claudia Manini ◽  
José I. López
Keyword(s):  
Bladder Cancer ◽  
Transitional Cell ◽  
Molecular Data ◽  
The Other ◽  
Diagnostic Problem ◽  
Histological Features ◽  
Myxoid Stroma ◽  
Signet Ring ◽  
Prognostic Implications ◽  
Basaloid Squamous

The overwhelming majority of bladder cancers are transitional cell carcinomas. Albeit mostly monotonous, carcinomas in the bladder may occasionally display a broad spectrum of histological features that should be recognized by pathologists because some of them represent a diagnostic problem and/or lead prognostic implications. Sometimes these features are focal in the context of conventional transitional cell carcinomas, but some others are generalized across the tumor making its recognition a challenge. For practical purposes, the review distributes the morphologic spectrum of changes in architectural and cytological. So, nested and large nested, micropapillary, myxoid stroma, small tubules and adenoma nephrogenic-like, microcystic, verrucous, and diffuse lymphoepithelioma-like, on one hand, and plasmacytoid, signet ring, basaloid-squamous, yolk-sac, trophoblastic, rhabdoid, lipid/lipoblastic, giant, clear, eosinophilic (oncocytoid), and sarcomatoid, on the other, are revisited. Key histological and immunohistochemical features useful in the differential diagnosis are mentioned. In selected cases, molecular data associated with the diagnosis, prognosis, and/or treatment are also included.

scholarly journals Identifying the ErbB/MAPK Signaling Cascade as a Therapeutic Target in Canine Bladder Cancer

2019 ◽  
Vol 96 (1) ◽  
pp. 36-46 ◽  
Author(s):  
Kathryn E. Cronise ◽  
Belen G. Hernandez ◽  
Daniel L. Gustafson ◽  
Dawn L. Duval
Keyword(s):  
Bladder Cancer ◽  
Therapeutic Target ◽  
Mapk Signaling ◽  
Signaling Cascade ◽  
Canine Bladder Cancer

CELL-FREE DNA IN SERUM OF PATIENTS WITH BLADDER CANCER: DIAGNOSTIC AND PROGNOSTIC IMPLICATIONS

2008 ◽  
Vol 7 (3) ◽  
pp. 207 ◽  
Author(s):  
J Ellinger ◽  
N Ellinger ◽  
L.C. Heukamp ◽  
P Kahl ◽  
F.G. Perabo ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cell Free Dna ◽  
Cancer Diagnostic ◽  
Free Dna ◽  
Prognostic Implications

scholarly journals IL-6 Promotes the Proliferation and Immunosuppressive Function of Myeloid-Derived Suppressor Cells via the MAPK Signaling Pathway in Bladder Cancer

2021 ◽  
Vol 2021 ◽  
pp. 1-18
Author(s):  
Zhong Zheng ◽  
Xinyi Zheng ◽  
Yiwen Zhu ◽  
Zhixian Yao ◽  
Weiguang Zhao ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Signaling Pathway ◽  
Suppressor Cells ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Mitogen Activated Protein Kinase ◽  
Myeloid Derived Suppressor Cells ◽  
Mitogen Activated Protein ◽  
Proliferation Ability ◽  
Muscle Invasive

Muscle-invasive bladder cancer (MIBC) is characterized by a highly complex immune environment, which is not well understood. Interleukin-6 (IL-6) is generated and secreted by multifarious types of cells, including tumor cells. This study was aimed at demonstrating that the levels of IL-6 and the number of myeloid-derived suppressor cells (MDSCs), with a positive correlation between them, increased in MIBC tissues, promoting MIBC cell proliferation, especially in patients with recurrence. In coculture analysis, MDSCs, with the stimulation of IL-6, could significantly lower the proliferation ability of CD4+ or CD8+ T lymphocytes. Further, this study demonstrated that IL-6 could upregulate the mitogen-activated protein kinase (MAPK) signaling pathway in MDSCs. The MAPK signaling inhibitor, aloesin, partially reversed the effects of IL-6 on MDSCs. These data suggested that IL-6 promoted MIBC progression by not only accelerating proliferation but also improving the immune suppression ability of MDSCs through activating the MAPK signaling pathway.

scholarly journals Circular RNA CEP128 promotes bladder cancer progression by regulating Mir‐145‐5p/ Myd88 via MAPK signaling pathway

2019 ◽  
Vol 145 (8) ◽  
pp. 2170-2181 ◽  
Author(s):  
Ming Sun ◽  
Wenyan Zhao ◽  
Zhaofu Chen ◽  
Ming Li ◽  
Shuqiang Li ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Signaling Pathway ◽  
Cancer Progression ◽  
Circular Rna ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway
Sign in / Sign up

Export Citation Format

Share Document