scholarly journals Pathological significance and prognostic implications of heme oxygenase 1 expression in non-muscle-invasive bladder cancer: Correlation with cell proliferation, angiogenesis, lymphangiogenesis and expression of VEGFs and COX-2

2016 ◽  
Vol 13 (1) ◽  
pp. 275-280 ◽  
Author(s):  
Tomohiro Matsuo ◽  
Yasuyoshi Miyata ◽  
Kensuke Mitsunari ◽  
Takuji Yasuda ◽  
Kojiro Ohba ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Bladder Cancer ◽  
Heme Oxygenase ◽  
Invasive Bladder Cancer ◽  
Heme Oxygenase 1 ◽  
Muscle Invasive Bladder Cancer ◽  
Cox 2 ◽  
Prognostic Implications ◽  
Muscle Invasive

Clinical Significance of Heme Oxygenase-1 Expression in Non-Muscle-Invasive Bladder Cancer

2010 ◽  
Vol 85 (3) ◽  
pp. 355-363 ◽  
Author(s):  
Makito Miyake ◽  
Kiyohide Fujimoto ◽  
Satoshi Anai ◽  
Sayuri Ohnishi ◽  
Yasushi Nakai ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Clinical Significance ◽  
Heme Oxygenase ◽  
Invasive Bladder Cancer ◽  
Heme Oxygenase 1 ◽  
Muscle Invasive Bladder Cancer ◽  
Muscle Invasive

JUND-dependent up-regulation of HMOX1 is associated with cisplatin resistance in muscle-invasive bladder cancer

2020 ◽  
Vol 168 (1) ◽  
pp. 73-82 ◽  
Author(s):  
Ye Peng ◽  
Yongjie Chen ◽  
Shiwei Chen ◽  
Jiaolian Wang ◽  
Cheng Jiang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bladder Cancer ◽  
Acquired Resistance ◽  
Genetically Engineered ◽  
Invasive Bladder Cancer ◽  
Clinical Samples ◽  
Heme Oxygenase 1 ◽  
Muscle Invasive Bladder Cancer ◽  
Platinum Based Chemotherapy ◽  
Muscle Invasive

Abstract The standard-of-care for metastatic muscle-invasive bladder cancer (MIBC) is platinum-based chemotherapy regimens. Acquired resistance that occurs frequently through unidentified mechanisms, however, remains the major obstacle for implementing therapeutic effectiveness. Here, using data mining and analysis on clinical samples, we show that expression of JUND, a core component of activator protein-1 family, was significantly induced in cisplatin (CDDP)-resistant MIBC. Accumulation of nuclear JUND was associated with low post-chemotherapy survival in MIBC patients. In both genetically engineered cell models and murine xenograft models, we provided evidence that bladder cancer (BC) cells with excessive JUND expression were less responsive to CDDP treatment. This CDDP resistance was further demonstrated to be mediated, at least in part, by transactivation of HMOX1 [the gene encoding heme oxygenase-1 (HO-1)], one of the most important antioxidant signalling pathways of cell adaptation to stress. One mutation within the HMOX1 promoter successfully abolished oxidative stress-enhanced and JUND-driven HMOX1 promoter activation, suggesting that this unique site synergized for maximal HO-1 induction in CDDP-challenged BC cells. Overall, our data highlight an indispensible role of JUND, both as a target as a modifier of the oxidative stress signalling, in conferring an adaptive response during the pathogenesis of CDDP resistance in MIBC.

scholarly journals Obatoclax, a BH3 Mimetic, Enhances Cisplatin-Induced Apoptosis and Decreases the Clonogenicity of Muscle Invasive Bladder Cancer Cells via Mechanisms That Involve the Inhibition of Pro-Survival Molecules as Well as Cell Cycle Regulators

2019 ◽  
Vol 20 (6) ◽  
pp. 1285 ◽  
Author(s):  
Thomas Steele ◽  
George Talbott ◽  
Anhao Sam ◽  
Clifford Tepper ◽  
Paramita Ghosh ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Bladder Cancer ◽  
Invasive Bladder Cancer ◽  
Dependent Manner ◽  
Cell Cycle Regulators ◽  
Muscle Invasive Bladder Cancer ◽  
Expression Levels ◽  
Muscle Invasive ◽  
Bh3 Mimetic

Several studies by our group and others have determined that expression levels of Bcl-2 and/or Bcl-xL, pro-survival molecules which are associated with chemoresistance, are elevated in patients with muscle invasive bladder cancer (MI-BC). The goal of this study was to determine whether combining Obatoclax, a BH3 mimetic which inhibits pro-survival Bcl-2 family members, can improve responses to cisplatin chemotherapy, the standard of care treatment for MI-BC. Three MI-BC cell lines (T24, TCCSuP, 5637) were treated with Obatoclax alone or in combination with cisplatin and/or pre-miR-34a, a molecule which we have previously shown to inhibit MI-BC cell proliferation via decreasing Cdk6 expression. Proliferation, clonogenic, and apoptosis assays confirmed that Obatoclax can decrease cell proliferation and promote apoptosis in a dose-dependent manner. Combination treatment experiments identified Obatoclax + cisplatin as the most effective treatment. Immunoprecipitation and Western analyses indicate that, in addition to being able to inhibit Bcl-2 and Bcl-xL, Obatoclax can also decrease cyclin D1 and Cdk4/6 expression levels. This has not previously been reported. The combined data demonstrate that Obatoclax can inhibit cell proliferation, promote apoptosis, and significantly enhance the effectiveness of cisplatin in MI-BC cells via mechanisms that likely involve the inhibition of both pro-survival molecules and cell cycle regulators.

scholarly journals Chromobox homolog 8 is a predictor of muscle invasive bladder cancer and promotes cell proliferation by repressing the p53 pathway

2017 ◽  
Vol 108 (11) ◽  
pp. 2166-2175 ◽  
Author(s):  
Gang‐jun Yuan ◽  
Xin Chen ◽  
Jun Lu ◽  
Zi‐hao Feng ◽  
Si‐liang Chen ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Bladder Cancer ◽  
Invasive Bladder Cancer ◽  
Muscle Invasive Bladder Cancer ◽  
P53 Pathway ◽  
Muscle Invasive

Prognostic Implications of Treatment Delays for Patients with Non–muscle-invasive Bladder Cancer

2021 ◽  
Author(s):  
Said Ourfali ◽  
Xavier Matillon ◽  
Estelle Ricci ◽  
Hakim Fassi-Fehri ◽  
Mélanie Benoit-Janin ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Invasive Bladder Cancer ◽  
Muscle Invasive Bladder Cancer ◽  
Treatment Delays ◽  
Prognostic Implications ◽  
Muscle Invasive

Prognostic implications of prostatic urethral involvement in non-muscle-invasive bladder cancer

2019 ◽  
Vol 37 (12) ◽  
pp. 2683-2689
Author(s):  
Aaron Brant ◽  
Marcus Daniels ◽  
Meera R. Chappidi ◽  
Gregory A. Joice ◽  
Nikolai A. Sopko ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Invasive Bladder Cancer ◽  
Muscle Invasive Bladder Cancer ◽  
Prognostic Implications ◽  
Muscle Invasive
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