scholarly journals Integrated genetic and epigenetic analysis revealed heterogeneity of acute lymphoblastic leukemia in Down syndrome

2019 ◽  
Vol 110 (10) ◽  
pp. 3358-3367 ◽  
Author(s):  
Yasuo Kubota ◽  
Kumiko Uryu ◽  
Tatsuya Ito ◽  
Masafumi Seki ◽  
Tomoko Kawai ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Epigenetic Analysis

scholarly journals Feasibility and Potential Benefits of an Exercise Intervention in a Male With Down Syndrome Undergoing High-Dose Chemotherapy for Acute Lymphoblastic Leukemia: A Case Report

2019 ◽  
Vol 18 ◽  
pp. 153473541983235
Author(s):  
Linda Bühl ◽  
Thomas Abel ◽  
Florian Wolf ◽  
Max Oberste ◽  
Wilhelm Bloch ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Acute Lymphoblastic Leukemia ◽  
Hematological Malignancies ◽  
Exercise Intervention ◽  
Lymphoblastic Leukemia ◽  
High Dose Chemotherapy ◽  
High Dose ◽  
Serious Adverse Events ◽  
Increased Risk ◽  
Potential Benefits

In patients with hematological malignancies, exercise is studied as a supportive measure with potential benefits on therapy and disease-related side effects. However, clinical trials have not yet integrated people with Down syndrome (DS), although this disability is associated with an increased risk for hematological malignancies. Therefore, we examined safety and feasibility of a mixed-modality exercise intervention in a male with DS undergoing high-dose chemotherapy for acute lymphoblastic leukemia. Furthermore, physical capacity and fatigue were assessed. Exercise sessions took place 3 times/wk over a 5-week period. Adherence to the exercise program was 100%, and no serious adverse events occurred. In contrast to the training sessions, applied endurance testing was not feasible. Furthermore, maintenance of fatigue level was observed. In conclusion, cancer patients with DS suffering from leukemia should not be excluded from physical activity or exercise programs.

Dasatinib and low‐intensity chemotherapy for Philadelphia chromosome‐positive acute lymphoblastic leukemia in a child with Down syndrome

2019 ◽  
Vol 66 (5) ◽  
pp. e27612 ◽  
Author(s):  
Shinsuke Hirabayashi ◽  
Daisuke Hasegawa ◽  
Kaoru Yamamoto ◽  
Akira Nishimura ◽  
Yosuke Hosoya ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Philadelphia Chromosome ◽  
Low Intensity ◽  
Philadelphia Chromosome Positive

Acute lymphoblastic leukemia in children and Down syndrome: Analysis of SHOP/ALL-’99 and ‘05 Protocols

2010 ◽  
Vol 14 (3) ◽  
pp. 36-46 ◽  
Author(s):  
M. García-Bernal ◽  
R. Cilveti ◽  
M. Villa ◽  
J. Molina ◽  
R. Fernández-Delgado ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Syndrome Analysis ◽  
Leukemia In Children
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