Dasatinib and low‐intensity chemotherapy for Philadelphia chromosome‐positive acute lymphoblastic leukemia in a child with Down syndrome

2019 ◽  
Vol 66 (5) ◽  
pp. e27612 ◽  
Author(s):  
Shinsuke Hirabayashi ◽  
Daisuke Hasegawa ◽  
Kaoru Yamamoto ◽  
Akira Nishimura ◽  
Yosuke Hosoya ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Philadelphia Chromosome ◽  
Low Intensity ◽  
Philadelphia Chromosome Positive

Philadelphia chromosome-positive acute lymphoblastic leukemia and Down syndrome

2016 ◽  
Vol 58 (8) ◽  
pp. 794-797 ◽  
Author(s):  
Moe Tamaura ◽  
Fuminori Iwasaki ◽  
Tomoko Yokosuka ◽  
Kunio Fukuda ◽  
Satoshi Hamonoue ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Philadelphia Chromosome ◽  
Philadelphia Chromosome Positive

scholarly journals P190BCR-ABL1 in a Patient with Philadelphia Chromosome Positive T-Cell Acute Lymphoblastic Leukemia: A Rare Case Report and Review of Literature

2021 ◽  
pp. 1040-1050
Author(s):  
Samah Kohla ◽  
Sarah EL Kourashy ◽  
Zafar Nawaz ◽  
Reda Youssef ◽  
Ahmad Al-Sabbagh ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
T Cell ◽  
Rare Case ◽  
De Novo ◽  
Lymphoblastic Leukemia ◽  
Prognostic Significance ◽  
Philadelphia Chromosome ◽  
Cytogenetic Abnormality ◽  
Rare Case Report ◽  
Philadelphia Chromosome Positive

T-acute lymphoblastic leukemia/lymphoblastic lymphoma (T-ALL/LBL) is rare and aggressive leukemia. Philadelphia chromosome positive (Ph+) is the most common cytogenetic abnormality in chronic myeloid leukemia (CML) and B-acute lymphoblastic leukemia (B-ALL). Ph+ T-ALL is exceeding rare and has a therapeutic and prognostic significance. The incidence and outcome of Ph+ T-ALL are unknown. Differentiation between Ph+ T-ALL/LBL and T-cell lymphoblastic crises of CML may be difficult. We report a rare case of adult de novo T-ALL with significant monocytosis, having Ph+ with (P190 <i>BCR-ABL1</i>) as a cytogenetic abnormality. He was treated with ALL induction chemotherapy and imatinib and achieved complete remission, then relapsed twice and expired shortly after the last CNS relapse.

scholarly journals Imatinib compared with chemotherapy as front-line treatment of elderly patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL)

Cancer ◽  
2007 ◽  
Vol 109 (10) ◽  
pp. 2068-2076 ◽  
Author(s):  
Oliver G. Ottmann ◽  
Barbara Wassmann ◽  
Heike Pfeifer ◽  
Aristoteles Giagounidis ◽  
Matthias Stelljes ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Elderly Patients ◽  
Lymphoblastic Leukemia ◽  
Philadelphia Chromosome ◽  
Line Treatment ◽  
Front Line ◽  
Philadelphia Chromosome Positive
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