scholarly journals Downregulation of ULK 1 by micro RNA ‐372 inhibits the survival of human pancreatic adenocarcinoma cells

2017 ◽  
Vol 108 (9) ◽  
pp. 1811-1819 ◽  
Author(s):  
Hongxi Chen ◽  
Zhipeng Zhang ◽  
Yebin Lu ◽  
Kun Song ◽  
Xiwu Liu ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Micro Rna ◽  
Human Pancreatic Adenocarcinoma ◽  
Adenocarcinoma Cells

Garcinol sensitizes human pancreatic adenocarcinoma cells to gemcitabine in association with microRNA signatures

2013 ◽  
Vol 57 (2) ◽  
pp. 235-248 ◽  
Author(s):  
Mansi A. Parasramka ◽  
Shadan Ali ◽  
Sanjeev Banerjee ◽  
Tara Deryavoush ◽  
Fazlul H Sarkar ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Human Pancreatic Adenocarcinoma ◽  
Adenocarcinoma Cells

scholarly journals 5′-Nucleotidases of chicken gizzard and human pancreatic adenocarcinoma cells are anchored to the plasma membrane via a phosphatidylinositol–glycan

1989 ◽  
Vol 262 (1) ◽  
pp. 33-40 ◽  
Author(s):  
U Stochaj ◽  
K Flocke ◽  
W Mathes ◽  
H G Mannherz
Keyword(s):  
Plasma Membrane ◽  
Pancreatic Adenocarcinoma ◽  
Plasma Membranes ◽  
Chicken Gizzard ◽  
Human Pancreatic Adenocarcinoma ◽  
Adenocarcinoma Cells ◽  
Increased Sensitivity ◽  
Membrane Bound ◽  
Membrane Anchoring ◽  
Pancreatic Adenocarcinoma Cell Line

We have analysed the membrane anchorage of plasma-membrane 5′-nucleotidase, an ectoenzyme which can mediate binding to components of the extracellular matrix. We demonstrated that the purified enzyme obtained from chicken gizzard and a human pancreatic adenocarcinoma cell line were both completely transformed into a hydrophilic form by treatment with phospholipases C and D, cleaving glycosylphosphatidylinositol (GPI). These data indicate the presence of a glycolipid linker employed for membrane anchoring of the 5′-nucleotidase obtained from both sources. Incubation of plasma membranes under identical conditions revealed that about half of the AMPase activity was resistant to GPI-hydrolysing phospholipases. Investigation of the enzymic properties of purified chicken gizzard 5′-nucleotidase revealed only minor changes after removal of the phosphatidylinositol linker. However, cleavage of the membrane anchor resulted in an increased sensitivity towards inhibition by concanavalin A. After tissue fractionation, chicken gizzard 5′-nucleotidase could be obtained as either a membrane-bound or a soluble protein; the latter is suspected to be released from the plasma membrane by endogenous phospholipases. Higher-molecular-mass proteins immuno-cross-reactive with the purified chicken gizzard 5′-nucleotidase were detected as both soluble and membrane-bound forms.

scholarly journals Anticancer properties of erucin, an H2S-releasing isothiocyanate, on human pancreatic adenocarcinoma cells (AsPC-1)

2019 ◽  
Vol 33 (3) ◽  
pp. 845-855 ◽  
Author(s):  
Valentina Citi ◽  
Eugenia Piragine ◽  
Eleonora Pagnotta ◽  
Luisa Ugolini ◽  
Lorenzo Di Cesare Mannelli ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Anticancer Properties ◽  
Human Pancreatic Adenocarcinoma ◽  
Adenocarcinoma Cells

EGCG downregulates IL-1RI expression and suppresses IL-1-induced tumorigenic factors in human pancreatic adenocarcinoma cells

2011 ◽  
Vol 82 (9) ◽  
pp. 1153-1162 ◽  
Author(s):  
Julia Hoffmann ◽  
Heike Junker ◽  
Annett Schmieder ◽  
Simone Venz ◽  
Rowena Brandt ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
Human Pancreatic Adenocarcinoma ◽  
Adenocarcinoma Cells

Lysis of human pancreatic adenocarcinoma cells by autologous hla-class I-restricted cytolytic T-lymphocyte (CTL) clones

1993 ◽  
Vol 54 (4) ◽  
pp. 636-644 ◽  
Author(s):  
Thomas Wölfel ◽  
Wolfgang Herr ◽  
Pierre Couue ◽  
Ute Schmitt ◽  
Karl-Hermann Meyer Zum Büschenfelde ◽  
...  
Keyword(s):  
Pancreatic Adenocarcinoma ◽  
T Lymphocyte ◽  
Hla Class I ◽  
Class I ◽  
Human Pancreatic Adenocarcinoma ◽  
Adenocarcinoma Cells ◽  
Cytolytic T Lymphocyte

Characterization of a Cancer Stem Cell-Like Side Population Derived from Human Pancreatic Adenocarcinoma Cells

2010 ◽  
Vol 96 (6) ◽  
pp. 985-992 ◽  
Author(s):  
Shi-Neng Zhang ◽  
Feng-Ting Huang ◽  
Yi-Jun Huang ◽  
Wa Zhong ◽  
Zhong Yu
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Pancreatic Adenocarcinoma ◽  
Side Population ◽  
Human Pancreatic Adenocarcinoma ◽  
Adenocarcinoma Cells
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