scholarly journals Receptor tyrosine kinase amplification is predictive of distant metastasis in patients with oral squamous cell carcinoma

2017 ◽  
Vol 108 (2) ◽  
pp. 256-266 ◽  
Author(s):  
Yu Oikawa ◽  
Kei-ichi Morita ◽  
Kou Kayamori ◽  
Kousuke Tanimoto ◽  
Kei Sakamoto ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Tyrosine Kinase ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Receptor Tyrosine Kinase ◽  
Distant Metastasis

scholarly journals Risk factors for distant metastasis in locoregionally controlled oral squamous cell carcinoma: a retrospective study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hirofumi Tomioka ◽  
Yuko Yamagata ◽  
Yu Oikawa ◽  
Toshimitsu Ohsako ◽  
Takuma Kugimoto ◽  
...  
Keyword(s):  
Risk Factors ◽  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Distant Metastasis ◽  
Significant Risk ◽  
Distant Metastases ◽  
Cervical Lymph Node Metastasis ◽  
Extranodal Extension

AbstractThe control of distant metastasis in oral squamous cell carcinoma is an important determinant of improved prognosis. The study aimed to identify risk factors for distant metastasis in patients with locoregionally controlled oral carcinoma. We identified 982 patients with oral squamous cell carcinoma treated at our hospital between January 2008 and December 2017. After excluding patients with distant metastasis at initial treatment, patients with metastasis to the oral cavity, those receiving palliative treatment, and those lacking follow-up data, 941 patients were selected. Finally, among these 941 patients, 887 with locoregionally controlled oral squamous cell carcinoma were included in the study. Among the 887 patients, 36 had confirmed distant metastasis (4.1%), and the lung was the most common site (31/36 patients, 86.1%). Multivariate analysis showed that the incidence of primary intraosseous carcinoma of the mandible, cervical lymph node metastasis at levels IV and V, and the presence of pathological extranodal extension were significant risk factors for distant metastasis. When treating patients with oral squamous cell carcinoma who are positive for the aforementioned risk factors, the possibility of developing distant metastases must be accounted for, and aggressive treatment should be planned accordingly.

scholarly journals Nerve growth factor and its receptor tyrosine kinase TrkA are overexpressed in cervical squamous cell carcinoma

2020 ◽  
Vol 2 (7) ◽  
pp. 398-408
Author(s):  
Sam Faulkner ◽  
Nathan Griffin ◽  
Christopher W. Rowe ◽  
Phillip Jobling ◽  
Janine M. Lombard ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Tyrosine Kinase ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Receptor Tyrosine Kinase ◽  
Cervical Squamous Cell Carcinoma ◽  
Nerve Growth

scholarly journals The receptor tyrosine kinase Axl regulates cell–cell adhesion and stemness in cutaneous squamous cell carcinoma

Oncogene ◽  
2013 ◽  
Vol 33 (32) ◽  
pp. 4185-4192 ◽  
Author(s):  
M A Cichoń ◽  
Z Szentpetery ◽  
M P Caley ◽  
E S Papadakis ◽  
I C Mackenzie ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Adhesion ◽  
Tyrosine Kinase ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Receptor Tyrosine Kinase ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Cell Cell
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