scholarly journals The receptor tyrosine kinase Axl regulates cell–cell adhesion and stemness in cutaneous squamous cell carcinoma

Oncogene ◽  
2013 ◽  
Vol 33 (32) ◽  
pp. 4185-4192 ◽  
Author(s):  
M A Cichoń ◽  
Z Szentpetery ◽  
M P Caley ◽  
E S Papadakis ◽  
I C Mackenzie ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Adhesion ◽  
Tyrosine Kinase ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Receptor Tyrosine Kinase ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Cell Cell

scholarly journals Nectin Cell Adhesion Molecule 4 (NECTIN4) Expression in Cutaneous Squamous Cell Carcinoma: A New Therapeutic Target?

Biomedicines ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 355
Author(s):  
Yuka Tanaka ◽  
Maho Murata ◽  
Yoshinao Oda ◽  
Masutaka Furue ◽  
Takamichi Ito
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Adhesion ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Adhesion Molecule ◽  
Therapeutic Target ◽  
Cell Adhesion Molecule ◽  
Cell Attachment ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Cell Cell

Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer, and its incidence is rising because of the aging population. Nectin cell adhesion molecule 4 (NECTIN4) is involved in the progression of tumors and has attracted interest as a potential therapeutic target. However, little is known about the expression and significance of NECTIN4 in cSCC. The aim of this study was to determine the expression and function of NECTIN4 in cSCC. Immunohistological NECTIN4 expression was investigated in tissues from 34 cSCC patients. Using an A431 human SCC cell line, the role of NECTIN4 in the regulation of cell–cell attachment and migration and proliferation was assessed. NECTIN4 was expressed in most cSCC tissues and on the plasma membrane of A431 cells. Silencing of NECTIN4 prevented cell–cell attachment and induced the expression migration-related molecules, leading to an increase in cell migration. Knockdown of NECTIN4 downregulated extracellular signal-regulated kinase signaling, decreased cyclin D1 expression, and inhibited cell proliferation. These results show that NECTIN4 is expressed in cSCC and functions in the regulation of cell–cell interactions, as well as in the migration and proliferation of SCC cells. NECTIN4-targeted therapy may serve as a novel and promising treatment for cSCC.

scholarly journals Nerve growth factor and its receptor tyrosine kinase TrkA are overexpressed in cervical squamous cell carcinoma

2020 ◽  
Vol 2 (7) ◽  
pp. 398-408
Author(s):  
Sam Faulkner ◽  
Nathan Griffin ◽  
Christopher W. Rowe ◽  
Phillip Jobling ◽  
Janine M. Lombard ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Tyrosine Kinase ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Receptor Tyrosine Kinase ◽  
Cervical Squamous Cell Carcinoma ◽  
Nerve Growth
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