scholarly journals Pancreatic cancer‐secreted miR‐155 implicates in the conversion from normal fibroblasts to cancer‐associated fibroblasts

2015 ◽  
Vol 106 (10) ◽  
pp. 1362-1369 ◽  
Author(s):  
Wenjing Pang ◽  
Jiaojiao Su ◽  
Yalei Wang ◽  
Hui Feng ◽  
Xin Dai ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Associated Fibroblasts

Abstract PR-015: Cancer-associated fibroblasts sustain critical dependency of pancreatic cancer cells on exogenous lipids

2021 ◽  
Author(s):  
Charline Ogier ◽  
Alena Klochkova ◽  
Linara Gabitova ◽  
Battuya Bayarmagnai ◽  
Diana Restifo ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Cancer Associated Fibroblasts ◽  
Pancreatic Cancer Cells

scholarly journals The Role of Autophagy in Pancreatic Cancer: From Bench to the Dark Bedside

Cells ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 1063 ◽  
Author(s):  
Kıvanç Görgülü ◽  
Kalliope N. Diakopoulos ◽  
Ezgi Kaya-Aksoy ◽  
Katrin J. Ciecielski ◽  
Jiaoyu Ai ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Fine Tuning ◽  
Cancer Tissue ◽  
Dependent Manner ◽  
Cancer Associated Fibroblasts ◽  
Preneoplastic Lesions ◽  
Pancreatic Cancer Tissue ◽  
Cancer Types ◽  
Initiation Stage

Pancreatic cancer is one of the deadliest cancer types urgently requiring effective therapeutic strategies. Autophagy occurs in several compartments of pancreatic cancer tissue including cancer cells, cancer associated fibroblasts, and immune cells where it can be subjected to a multitude of stimulatory and inhibitory signals fine-tuning its activity. Therefore, the effects of autophagy on pancreatic carcinogenesis and progression differ in a stage and context dependent manner. In the initiation stage autophagy hinders development of preneoplastic lesions; in the progression stage however, autophagy promotes tumor growth. This double-edged action of autophagy makes it a hard therapeutic target. Indeed, autophagy inhibitors have not yet shown survival improvements in clinical trials, indicating a need for better evaluation of existing results and smarter targeting techniques. Clearly, the role of autophagy in pancreatic cancer is complex and many aspects have to be considered when moving from the bench to the bedside.

Abstract C156: GPCRs as potential therapeutic targets in pancreatic cancer-associated fibroblasts

2015 ◽  
Author(s):  
Shu Zhou ◽  
Sarah Chang ◽  
Thalia McCann ◽  
Randall French ◽  
Andrew M. Lowy ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Therapeutic Targets ◽  
Cancer Associated Fibroblasts
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