scholarly journals Animal models of diabetes‐associated vascular diseases: An update on available models and experimental analysis

2021 ◽  
Author(s):  
Judy S. Y. Choi ◽  
Judy B. Haan ◽  
Arpeeta Sharma
Keyword(s):  
Animal Models ◽  
Experimental Analysis ◽  
Vascular Diseases ◽  
Animal Models Of Diabetes

scholarly journals Animal models of diabetes-associated vascular diseases: An update on available models and experimental analysis

2020 ◽  
Author(s):  
Judy Choi ◽  
Judy de Haan ◽  
Arpeeta Sharma
Keyword(s):  
Animal Models ◽  
Experimental Analysis ◽  
Microvascular Complications ◽  
Vascular Complications ◽  
Vascular Diseases ◽  
Therapeutic Interventions ◽  
Molecular Pathways ◽  
Mortality And Morbidity ◽  
Diabetic Vascular Complications ◽  
Artery Disease

Diabetes is a chronic metabolic disorder associated with the accelerated development of macrovascular (atherosclerosis, coronary artery disease) and microvascular complications (nephropathy, retinopathy and neuropathy), which remain the principal cause of mortality and morbidity in this population. Current understanding of cellular and molecular pathways of diabetes-driven vascular complications as well as therapeutic interventions have arisen from studying disease pathogenesis in animal models. Diabetes-associated vascular complications are multi-faceted, involving the interaction between various cellular and molecular pathways. Thus, the choice of an appropriate animal model to study vascular pathogenesis is important in our quest to identify innovative and mechanism-based targeted therapies to reduce the burden of diabetic complications. Herein, we provide up-to-date information on available mouse models of both Type 1 and Type 2 diabetic vascular complications as well as experimental analysis and research outputs.

scholarly journals Animal Models of Diabetes and Its Associated Complications

2013 ◽  
Vol 2013 ◽  
pp. 1-1 ◽  
Author(s):  
Md. Shahidul Islam ◽  
Daisuke Koya ◽  
Bernard Portha
Keyword(s):  
Animal Models ◽  
Animal Models Of Diabetes

Noninsulin-Dependent Animal Models of Diabetes Mellitus

2018 ◽  
pp. 337-398
Author(s):  
Christopher H. S. McIntosh ◽  
Raymond A. Pederson
Keyword(s):  
Diabetes Mellitus ◽  
Animal Models ◽  
Animal Models Of Diabetes

scholarly journals Hypoglycemic effect of quercetin in animal models of diabetes

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Haneul Choi ◽  
Jungin Kim ◽  
Jihye Kim ◽  
Heejeong Joo ◽  
Younghee Kang
Keyword(s):  
Animal Models ◽  
Hypoglycemic Effect ◽  
Animal Models Of Diabetes

scholarly journals Antiartherosclerotic Effects of Plant Flavonoids

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Shamala Salvamani ◽  
Baskaran Gunasekaran ◽  
Noor Azmi Shaharuddin ◽  
Siti Aqlima Ahmad ◽  
Mohd Yunus Shukor
Keyword(s):  
Cardiovascular Diseases ◽  
Side Effects ◽  
Animal Models ◽  
Vascular Diseases ◽  
Lipid Lowering ◽  
Peripheral Vascular ◽  
Heart Attacks ◽  
Synthetic Drug

Atherosclerosis is the process of hardening and narrowing the arteries. Atherosclerosis is generally associated with cardiovascular diseases such as strokes, heart attacks, and peripheral vascular diseases. Since the usage of the synthetic drug, statins, leads to various side effects, the plants flavonoids with antiartherosclerotic activity gained much attention and were proven to reduce the risk of atherosclerosisin vitroandin vivobased on different animal models. The flavonoids compounds also exhibit lipid lowering effects and anti-inflammatory and antiatherogenic properties. The future development of flavonoids-based drugs is believed to provide significant effects on atherosclerosis and its related diseases. This paper discusses the antiatherosclerotic effects of selected plant flavonoids such as quercetin, kaempferol, myricetin, rutin, naringenin, catechin, fisetin, and gossypetin.

Animal Models of Diabetes-Induced Neuropathic Pain

2014 ◽  
pp. 147-170 ◽  
Author(s):  
Corinne A. Lee-Kubli ◽  
Teresa Mixcoatl-Zecuatl ◽  
Corinne G. Jolivalt ◽  
Nigel A. Calcutt
Keyword(s):  
Neuropathic Pain ◽  
Animal Models ◽  
Animal Models Of Diabetes

scholarly journals Computational Fluid Dynamics of Vascular Disease in Animal Models

2018 ◽  
Vol 140 (8) ◽  
Author(s):  
Andrea Acuna ◽  
Alycia G. Berman ◽  
Frederick W. Damen ◽  
Brett A. Meyers ◽  
Amelia R. Adelsperger ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Computational Fluid Dynamics ◽  
Animal Models ◽  
Vascular Disease ◽  
Vascular Diseases ◽  
Cfd Modeling ◽  
Shear Stresses ◽  
Human Patient ◽  
Arteriovenous Fistulas ◽  
The Impact

Recent applications of computational fluid dynamics (CFD) applied to the cardiovascular system have demonstrated its power in investigating the impact of hemodynamics on disease initiation, progression, and treatment outcomes. Flow metrics such as pressure distributions, wall shear stresses (WSS), and blood velocity profiles can be quantified to provide insight into observed pathologies, assist with surgical planning, or even predict disease progression. While numerous studies have performed simulations on clinical human patient data, it often lacks prediagnosis information and can be subject to large intersubject variability, limiting the generalizability of findings. Thus, animal models are often used to identify and manipulate specific factors contributing to vascular disease because they provide a more controlled environment. In this review, we explore the use of CFD in animal models in recent studies to investigate the initiating mechanisms, progression, and intervention effects of various vascular diseases. The first section provides a brief overview of the CFD theory and tools that are commonly used to study blood flow. The following sections are separated by anatomical region, with the abdominal, thoracic, and cerebral areas specifically highlighted. We discuss the associated benefits and obstacles to performing CFD modeling in each location. Finally, we highlight animal CFD studies focusing on common surgical treatments, including arteriovenous fistulas (AVF) and pulmonary artery grafts. The studies included in this review demonstrate the value of combining CFD with animal imaging and should encourage further research to optimize and expand upon these techniques for the study of vascular disease.

Animal models to study pathophysiology of the vasculature

2017 ◽  
Author(s):  
Wenduo Gu ◽  
Yao Xie ◽  
Qingbo Xu
Keyword(s):  
Animal Models ◽  
Environmental Factors ◽  
Blood Vessel ◽  
Vascular Diseases ◽  
Experimental System ◽  
Complete Analysis ◽  
Vascular Disorder ◽  
Transplant Arteriosclerosis ◽  
Major Progress ◽  
Prevention And Therapy

Animal models are designed to be preliminary tools for a better understanding of the pathogenesis, improvement in diagnosis, prevention, and therapy of vascular diseases in humans. Animal models are easily manageable, as compounding effects of dietary and environmental factors can be controlled experimentally. Blood vessel samples can be taken for detailed experimental and biomolecular examination. A thorough understanding of the animal models used is necessary and complete analysis must be validated so that the data can be extrapolated to humans. There are several species that are used for studying vascular pathophysiology, including mice, rats, rabbits, and pigs. Attracted by the well-defined genetic systems, a number of investigators have begun to use the mouse as an experimental system for arteriosclerosis research. Because vascular disorder is a complicated disease, which includes spontaneous (native) atherosclerosis, transplant arteriosclerosis, vein graft atherosclerosis, and angioplasty-induced restenosis, several models for studying all types of vascular disease have recently been established. Using these animal models, much knowledge concerning the pathogenesis of the disease and therapeutic intervention has been gained. This chapter will not attempt to cover all aspects of animal models, but will rather focus on the major progress in understanding the pathophysiology of the vasculature, the (dis)advantages of a variety of models, and how specific models can be appropriately chosen for different purposes of study.

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