scholarly journals Computational Fluid Dynamics of Vascular Disease in Animal Models

2018 ◽  
Vol 140 (8) ◽  
Author(s):  
Andrea Acuna ◽  
Alycia G. Berman ◽  
Frederick W. Damen ◽  
Brett A. Meyers ◽  
Amelia R. Adelsperger ◽  
...  

Recent applications of computational fluid dynamics (CFD) applied to the cardiovascular system have demonstrated its power in investigating the impact of hemodynamics on disease initiation, progression, and treatment outcomes. Flow metrics such as pressure distributions, wall shear stresses (WSS), and blood velocity profiles can be quantified to provide insight into observed pathologies, assist with surgical planning, or even predict disease progression. While numerous studies have performed simulations on clinical human patient data, it often lacks prediagnosis information and can be subject to large intersubject variability, limiting the generalizability of findings. Thus, animal models are often used to identify and manipulate specific factors contributing to vascular disease because they provide a more controlled environment. In this review, we explore the use of CFD in animal models in recent studies to investigate the initiating mechanisms, progression, and intervention effects of various vascular diseases. The first section provides a brief overview of the CFD theory and tools that are commonly used to study blood flow. The following sections are separated by anatomical region, with the abdominal, thoracic, and cerebral areas specifically highlighted. We discuss the associated benefits and obstacles to performing CFD modeling in each location. Finally, we highlight animal CFD studies focusing on common surgical treatments, including arteriovenous fistulas (AVF) and pulmonary artery grafts. The studies included in this review demonstrate the value of combining CFD with animal imaging and should encourage further research to optimize and expand upon these techniques for the study of vascular disease.

Author(s):  
Vibhor Mehrotra ◽  
Philip Diwakar ◽  
Rimon Vallavanatt

Industrial application of Computational Fluid Dynamics (CFD) requires the solution of complex fluid-flow problems in conjunction with equipment design, process and product development and optimization. For the successful solution of these problems, a high degree of coordination between industrial CFD engineers, software developers, consultants and academic scientists is necessary. In a refinery, CFD may be applied to a variety of problems. In particular, combustion, flames, flares and chemical reaction are of interest because of the physics and the complex nature of the process. Two applications are presented in this paper to demonstrate the use of CFD modeling for improving furnace operations. The first concerns improvements in reboiler operation by changing burner arrangement. A three-burner arrangement has resulted in tube burnout in the past. CFD modeling suggested a four-burner arrangement is better. The recommendation was accepted and implemented by the refinery in 2002. Feedback from the refinery suggests a much cooler furnace operation is observed in the field. The second application concerns predicting Coker furnace operation of as yet uninstalled heater. The Coker radiant section is modeled with 4 burners. Predicting the impact of burner-burner interaction on the radiant heat flux helps in determining the time period for decoke. Several mitigation steps are suggested to increase the run length between decoking intervals. Further recommendation to create a balanced heat flux profile is provided.


Membranes ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 123
Author(s):  
Alberto Fernández ◽  
Cintia Casado ◽  
David Alique ◽  
José Antonio Calles ◽  
Javier Marugán

This work focused on the computational fluid dynamics (CFD) modeling of H2/N2 separation in a membrane permeator module containing a supported dense Pd-based membrane that was prepared using electroless pore-plating (ELP-PP). An easy-to-implement model was developed based on a source–sink pair formulation of the species transport and continuity equations. The model also included the Darcy–Forcheimer formulation for modeling the porous stainless steel (PSS) membrane support and Sieverts’ law for computing the H2 permeation flow through the dense palladium film. Two different reactor configurations were studied, which involved varying the hydrogen flow permeation direction (in–out or out–in). A wide range of experimental data was simulated by considering the impact of the operating conditions on the H2 separation, such as the feed pressure and the H2 concentration in the inlet stream. Simulations of the membrane permeator device showed an excellent agreement between the predicted and experimental data (measured as permeate and retentate flows and H2 separation). Molar fraction profiles inside the permeator device for both configurations showed that concentration polarization near the membrane surface was not a limit for the hydrogen permeation but could be useful information for membrane reactor design, as it showed the optimal length of the reactor.


Processes ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 79
Author(s):  
Minghan Luo ◽  
Wenjie Xu ◽  
Xiaorong Kang ◽  
Keqiang Ding ◽  
Taeseop Jeong

The ultraviolet photochemical degradation process is widely recognized as a low-cost, environmentally friendly, and sustainable technology for water treatment. This study integrated computational fluid dynamics (CFD) and a photoreactive kinetic model to investigate the effects of flow characteristics on the contaminant degradation performance of a rotating annular photoreactor with a vacuum-UV (VUV)/UV process performed in continuous flow mode. The results demonstrated that the introduced fluid remained in intensive rotational movement inside the reactor for a wide range of inflow rates, and the rotational movement was enhanced with increasing influent speed within the studied velocity range. The CFD modeling results were consistent with the experimental abatement of methylene blue (MB), although the model slightly overestimated MB degradation because it did not fully account for the consumption of OH radicals from byproducts generated in the MB decomposition processes. The OH radical generation and contaminant degradation efficiency of the VUV/UV process showed strong correlation with the mixing level in a photoreactor, which confirmed the promising potential of the developed rotating annular VUV reactor in water treatment.


Author(s):  
Praween Senanayake ◽  
Hana Salati ◽  
Eugene Wong ◽  
Kimberley Bradshaw ◽  
Yidan Shang ◽  
...  

2021 ◽  
Vol 2021 (6) ◽  
pp. 5421-5425
Author(s):  
MICHAL RICHTAR ◽  
◽  
PETRA MUCKOVA ◽  
JAN FAMFULIK ◽  
JAKUB SMIRAUS ◽  
...  

The aim of the article is to present the possibilities of application of computational fluid dynamics (CFD) to modelling of air flow in combustion engine intake manifold depending on airbox configuration. The non-stationary flow occurs in internal combustion engines. This is a specific type of flow characterized by the fact that the variables depend not only on the position but also on the time. The intake manifold dimension and geometry strongly effects intake air amount. The basic target goal is to investigate how the intake trumpet position in the airbox impacts the filling of the combustion chamber. Furthermore, the effect of different distances between the trumpet neck and the airbox wall in this paper will be compared.


2021 ◽  
Author(s):  
Sanaz Dianat

The research paper investigates the impact of a window’s exterior air film on the assembly temperature. The exterior air film constitutes a vital portion of a window’s insulating values. The air film increases the temperature of the window exterior pane to a temperature above ambient temperature. The air film also rises the interior glass temperature and reduces the heat transfer from the interior surface. According to computational fluid dynamics (CFD), the air film is removed in windy conditions, decreasing the window temperature on the outside as well as on the inside. The idea behind the project is to carry out an experimental procedure on three different windows to validate the CFD results, which indicates the effect of various wind speeds. Keyword: Exterior air film, computational fluid dynamics, window assembly, wind speed


2021 ◽  
Author(s):  
Sanaz Dianat

The research paper investigates the impact of a window’s exterior air film on the assembly temperature. The exterior air film constitutes a vital portion of a window’s insulating values. The air film increases the temperature of the window exterior pane to a temperature above ambient temperature. The air film also rises the interior glass temperature and reduces the heat transfer from the interior surface. According to computational fluid dynamics (CFD), the air film is removed in windy conditions, decreasing the window temperature on the outside as well as on the inside. The idea behind the project is to carry out an experimental procedure on three different windows to validate the CFD results, which indicates the effect of various wind speeds. Keyword: Exterior air film, computational fluid dynamics, window assembly, wind speed


2019 ◽  
Vol 141 (4) ◽  
Author(s):  
Michael P. Kinzel ◽  
Jules W. Lindau ◽  
Robert F. Kunz

This effort investigates advancing cavitation modeling relevant to computational fluid dynamics (CFD) through two strategies. The first aims to reformulate the cavitation models and the second explores adding liquid–vapor slippage effects. The first aspect of the paper revisits cavitation model formulations with respect to the Rayleigh–Plesset equation (RPE). The present approach reformulates the cavitation model using analytic solutions to the RPE. The benefit of this reformulation is displayed by maintaining model sensitivities similar to RPE, whereas the standard models fail these tests. In addition, the model approach is extended beyond standard homogeneous models, to a two-fluid modeling framework that explicitly models the slippage between cavitation bubbles and the liquid. The results indicate a significant impact of slip on the predicted cavitation solution, suggesting that the inclusion of such modeling can potentially improve CFD cavitation models. Overall, the results of this effort point to various aspects that may be considered in future CFD-modeling efforts with the goal of improving the model accuracy and reducing computational time.


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