scholarly journals Emergency myelopoiesis contributes to immune cell exhaustion and pulmonary vascular remodelling

2020 ◽  
Vol 178 (1) ◽  
pp. 187-202 ◽  
Author(s):  
Chunhua Fu ◽  
Yuanqing Lu ◽  
Mason A. Williams ◽  
Mark L. Brantly ◽  
Corey E. Ventetuolo ◽  
...  
Keyword(s):  
Immune Cell ◽  
Vascular Remodelling ◽  
Cell Exhaustion ◽  
Emergency Myelopoiesis ◽  
Pulmonary Vascular Remodelling

Circulating fibrocytes in pulmonary vascular remodelling

Pneumologie ◽  
2009 ◽  
Vol 63 (02) ◽  
Author(s):  
V Nikam ◽  
G Hild ◽  
R Schermuley ◽  
R Dumitrascu ◽  
N Weissmann ◽  
...  
Keyword(s):  
Vascular Remodelling ◽  
Pulmonary Vascular Remodelling ◽  
Circulating Fibrocytes

VEGF synthesis is induced by prostacyclin and TGF-β in distal lung fibroblasts from COPD patients and control subjects: Implications for pulmonary vascular remodelling

Respirology ◽  
2017 ◽  
Vol 23 (1) ◽  
pp. 68-75 ◽  
Author(s):  
Gunilla Westergren-Thorsson ◽  
Mariam Bagher ◽  
Annika Andersson-Sjöland ◽  
Lena Thiman ◽  
Claes-Göran Löfdahl ◽  
...  
Keyword(s):  
Lung Fibroblasts ◽  
Vascular Remodelling ◽  
Control Subjects ◽  
Copd Patients ◽  
Distal Lung ◽  
And Control ◽  
Pulmonary Vascular Remodelling

Activation of PKCα and pulmonary vascular remodelling in broilers

2005 ◽  
Vol 79 (2) ◽  
pp. 131-137 ◽  
Author(s):  
Xun Tan ◽  
Yan-Juan Liu ◽  
Jin-Chun Li ◽  
Jia-Qiang Pan ◽  
Wei-Dong Sun ◽  
...  
Keyword(s):  
Vascular Remodelling ◽  
Pulmonary Vascular Remodelling

scholarly journals Role of tetrahydrobiopterin in pulmonary vascular remodelling associated with pulmonary fibrosis

Thorax ◽  
2013 ◽  
Vol 68 (10) ◽  
pp. 938-948 ◽  
Author(s):  
Patricia Almudéver ◽  
Javier Milara ◽  
Alfredo De Diego ◽  
Ana Serrano-Mollar ◽  
Antoni Xaubet ◽  
...  
Keyword(s):  
Pulmonary Fibrosis ◽  
Vascular Remodelling ◽  
Pulmonary Vascular Remodelling

scholarly journals Expressions of TOLL-like receptor 4 (TLR-4) and matrix metalloproteinase 9 (MMP-9)/Tissue inhibitor of metalloproteinase 1 (TIMP-1) in pulmonary blood vessels with chronic obstructive pulmonary diseases and their relationships with pulmonary vascular remodelling

2018 ◽  
Vol 64 (4) ◽  
pp. 361-367 ◽  
Author(s):  
Wen-Cheng Yu ◽  
Jin-Peng Cong ◽  
Li-Yun Mi
Keyword(s):  
Smooth Muscle ◽  
Matrix Metalloproteinase ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Control Group ◽  
Chronic Obstructive ◽  
Toll Like Receptor ◽  
Vascular Remodelling ◽  
Toll Like Receptor 4 ◽  
Metalloproteinase 9 ◽  
Pulmonary Vascular Remodelling

SUMMARY OBJECTIVE: This study aims at investigating the expressions of TOLL-like receptor 4 (TLR-4) and matrix metalloproteinase 9 (MMP-9)/ tissue inhibitor of metalloproteinase 1 (TIMP-1) in pulmonary blood vessels with chronic obstructive pulmonary disease (COPD) and their relationships with pulmonary vascular remodelling (PVR). METHODS: 60 para-tumour tissues were divided into the COPD group and the control group (n=30); the inflammations, pulmonary artery wall area/total artery area (WA%), and wall thickness/vascular outer diameter (WT%) were compared. The expressions of TLR-4, MMP-9/TIMP-1, and PCNA in pulmonary vascular smooth muscle cells were detected, and their relationships with PVR were then analysed. RESULTS: The inflammations (1.6±0.8), WA% (44.0±6.4), and WT% (27.3±3.3) in the COPD group were higher than in the control group (0.3±0.5, 26.1±2.8, 15.6±1.8), and the expressions of TLR-4 (31.4±147) and MMP-9/TIMP-1 (2.2±2.6) were increased compared to the control group (4.7±4.5, 1.9±12). Correlation analysis: TLR-4 and MMP-9/TIMP-1 were positively correlated with the inflammations (r=0.18, P<0.01), WA% (r=0.68, P<0.01), and WT% (r=0.73, P<0.01), as well as positively correlated with the expression of PCNA (r=0.44, P<0.01); the upregulation of TLR-4 was positively correlated with the expressions of MMP-9 and TIMP-1. CONCLUSIONS: The upregulation of TLR-4 in the pulmonary arterial smooth muscle cells of COPD patients could promote the inflammations and the MMP-9 expression, thus causing abnormal degradation of extracellular matrix, so it played an important role in the process of PVR.

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