scholarly journals MiR‐629 regulates hypoxic pulmonary vascular remodelling by targeting FOXO3 and PERP

2019 ◽  
Vol 23 (8) ◽  
pp. 5165-5175 ◽  
Author(s):  
Mei Zhao ◽  
Ni Chen ◽  
Xuelian Li ◽  
Ling Lin
Keyword(s):  
Vascular Remodelling ◽  
Pulmonary Vascular Remodelling

Circulating fibrocytes in pulmonary vascular remodelling

Pneumologie ◽  
2009 ◽  
Vol 63 (02) ◽  
Author(s):  
V Nikam ◽  
G Hild ◽  
R Schermuley ◽  
R Dumitrascu ◽  
N Weissmann ◽  
...  
Keyword(s):  
Vascular Remodelling ◽  
Pulmonary Vascular Remodelling ◽  
Circulating Fibrocytes

VEGF synthesis is induced by prostacyclin and TGF-β in distal lung fibroblasts from COPD patients and control subjects: Implications for pulmonary vascular remodelling

Respirology ◽  
2017 ◽  
Vol 23 (1) ◽  
pp. 68-75 ◽  
Author(s):  
Gunilla Westergren-Thorsson ◽  
Mariam Bagher ◽  
Annika Andersson-Sjöland ◽  
Lena Thiman ◽  
Claes-Göran Löfdahl ◽  
...  
Keyword(s):  
Lung Fibroblasts ◽  
Vascular Remodelling ◽  
Control Subjects ◽  
Copd Patients ◽  
Distal Lung ◽  
And Control ◽  
Pulmonary Vascular Remodelling

Activation of PKCα and pulmonary vascular remodelling in broilers

2005 ◽  
Vol 79 (2) ◽  
pp. 131-137 ◽  
Author(s):  
Xun Tan ◽  
Yan-Juan Liu ◽  
Jin-Chun Li ◽  
Jia-Qiang Pan ◽  
Wei-Dong Sun ◽  
...  
Keyword(s):  
Vascular Remodelling ◽  
Pulmonary Vascular Remodelling

scholarly journals Role of tetrahydrobiopterin in pulmonary vascular remodelling associated with pulmonary fibrosis

Thorax ◽  
2013 ◽  
Vol 68 (10) ◽  
pp. 938-948 ◽  
Author(s):  
Patricia Almudéver ◽  
Javier Milara ◽  
Alfredo De Diego ◽  
Ana Serrano-Mollar ◽  
Antoni Xaubet ◽  
...  
Keyword(s):  
Pulmonary Fibrosis ◽  
Vascular Remodelling ◽  
Pulmonary Vascular Remodelling

scholarly journals Expressions of TOLL-like receptor 4 (TLR-4) and matrix metalloproteinase 9 (MMP-9)/Tissue inhibitor of metalloproteinase 1 (TIMP-1) in pulmonary blood vessels with chronic obstructive pulmonary diseases and their relationships with pulmonary vascular remodelling

2018 ◽  
Vol 64 (4) ◽  
pp. 361-367 ◽  
Author(s):  
Wen-Cheng Yu ◽  
Jin-Peng Cong ◽  
Li-Yun Mi
Keyword(s):  
Smooth Muscle ◽  
Matrix Metalloproteinase ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Control Group ◽  
Chronic Obstructive ◽  
Toll Like Receptor ◽  
Vascular Remodelling ◽  
Toll Like Receptor 4 ◽  
Metalloproteinase 9 ◽  
Pulmonary Vascular Remodelling

SUMMARY OBJECTIVE: This study aims at investigating the expressions of TOLL-like receptor 4 (TLR-4) and matrix metalloproteinase 9 (MMP-9)/ tissue inhibitor of metalloproteinase 1 (TIMP-1) in pulmonary blood vessels with chronic obstructive pulmonary disease (COPD) and their relationships with pulmonary vascular remodelling (PVR). METHODS: 60 para-tumour tissues were divided into the COPD group and the control group (n=30); the inflammations, pulmonary artery wall area/total artery area (WA%), and wall thickness/vascular outer diameter (WT%) were compared. The expressions of TLR-4, MMP-9/TIMP-1, and PCNA in pulmonary vascular smooth muscle cells were detected, and their relationships with PVR were then analysed. RESULTS: The inflammations (1.6±0.8), WA% (44.0±6.4), and WT% (27.3±3.3) in the COPD group were higher than in the control group (0.3±0.5, 26.1±2.8, 15.6±1.8), and the expressions of TLR-4 (31.4±147) and MMP-9/TIMP-1 (2.2±2.6) were increased compared to the control group (4.7±4.5, 1.9±12). Correlation analysis: TLR-4 and MMP-9/TIMP-1 were positively correlated with the inflammations (r=0.18, P<0.01), WA% (r=0.68, P<0.01), and WT% (r=0.73, P<0.01), as well as positively correlated with the expression of PCNA (r=0.44, P<0.01); the upregulation of TLR-4 was positively correlated with the expressions of MMP-9 and TIMP-1. CONCLUSIONS: The upregulation of TLR-4 in the pulmonary arterial smooth muscle cells of COPD patients could promote the inflammations and the MMP-9 expression, thus causing abnormal degradation of extracellular matrix, so it played an important role in the process of PVR.

scholarly journals Nintedanib improves cardiac fibrosis but leaves pulmonary vascular remodelling unaltered in experimental pulmonary hypertension

2018 ◽  
Vol 115 (2) ◽  
pp. 432-439 ◽  
Author(s):  
Nina Rol ◽  
Michiel A de Raaf ◽  
Xiaoqing Q Sun ◽  
Vincent P Kuiper ◽  
Denielli da Silva Gonçalves Bos ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Cardiac Fibrosis ◽  
Vascular Remodelling ◽  
Pulmonary Vascular Remodelling
Sign in / Sign up

Export Citation Format

Share Document