scholarly journals Clinical relevance of St. John's wort drug interactions revisited

2020 ◽  
Vol 177 (6) ◽  
pp. 1212-1226 ◽  
Author(s):  
Simon Nicolussi ◽  
Jürgen Drewe ◽  
Veronika Butterweck ◽  
Henriette E. Meyer zu Schwabedissen
Keyword(s):  
Drug Interactions ◽  
Clinical Relevance ◽  
St John’S Wort ◽  
St John's Wort

St. John’s Wort: A Systematic Review of Adverse Effects and Drug Interactions for the Consultation Psychiatrist

2003 ◽  
Vol 44 (4) ◽  
pp. 271-282 ◽  
Author(s):  
Paul Hammerness ◽  
Ethan Basch ◽  
Catherine Ulbricht ◽  
E.-P. Barrette ◽  
Ivo Foppa ◽  
...  
Keyword(s):  
Systematic Review ◽  
Adverse Effects ◽  
Drug Interactions ◽  
St John’S Wort ◽  
St John's Wort

Drug Interactions with St. John's Wort

2010 ◽  
pp. 273-290
Author(s):  
Matthew D. Krasowski ◽  
John L. Blau
Keyword(s):  
Drug Interactions ◽  
St John’S Wort ◽  
St John's Wort

scholarly journals St John's wort (Hypericum perforatum ): drug interactions and clinical outcomes

2002 ◽  
Vol 54 (4) ◽  
pp. 349-356 ◽  
Author(s):  
L. Henderson ◽  
Q. Y. Yue ◽  
C. Bergquist ◽  
B. Gerden ◽  
P. Arlett
Keyword(s):  
Drug Interactions ◽  
Clinical Outcomes ◽  
Hypericum Perforatum ◽  
St John’S Wort ◽  
St John's Wort

Natural health product–HIV drug interactions: a systematic review

2005 ◽  
Vol 16 (3) ◽  
pp. 181-186 ◽  
Author(s):  
Edward Mills ◽  
Victor Montori ◽  
Dan Perri ◽  
Elizabeth Phillips ◽  
Gideon Koren
Keyword(s):  
Systematic Review ◽  
Vitamin C ◽  
Drug Interactions ◽  
Herbal Medicines ◽  
Drug Level ◽  
Natural Health Products ◽  
Natural Health ◽  
Clinical Pharmacokinetics ◽  
St John’S Wort ◽  
St John's Wort

The use of natural health products (NHPs) within the HIV community is high. Several NHPs have demonstrated interactions with HIV medications that could contribute to drug failure. We aimed to conduct a systematic review of clinical trials examining NHP–HIV drug interactions and their methodological characteristics. We searched electronic databases and unpublished resources independently, in duplicate. Nine studies were identified, eight clinical pharmacokinetics trials and one population-pharmacokinetics trial. Investigators studied four different herbal medicines (St John's wort, garlic, goldenseal and milk thistle) and one vitamin (vitamin C). Significant interactions were observed with St John's wort, garlic and vitamin C. However, methodological challenges exist to making the results directly generalizable to patients. This review finds that important drug level changes exist when NHPs are combined with HIV medications. Considering patient values and the implications of these studies, further research is urgently required to determine the extent of interactions with other commonly used NHPs.

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