scholarly journals Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence

2019 ◽  
Vol 177 (6) ◽  
pp. 1409-1423 ◽  
Author(s):  
Shian‐Ren Lin ◽  
Chia‐Hsiang Chang ◽  
Che‐Fang Hsu ◽  
May‐Jwan Tsai ◽  
Henrich Cheng ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Natural Compounds

Coagulation and Cancer Therapy: The Potential of Natural Compounds

2005 ◽  
Vol 6 (6) ◽  
pp. 461-469 ◽  
Author(s):  
G. Justo ◽  
C. Ferreira
Keyword(s):  
Cancer Therapy ◽  
Natural Compounds

scholarly journals Natural Compounds from Herbs that can Potentially Execute as Autophagy Inducers for Cancer Therapy

2017 ◽  
Vol 18 (7) ◽  
pp. 1412 ◽  
Author(s):  
Shian-Ren Lin ◽  
Yaw-Syan Fu ◽  
May-Jywan Tsai ◽  
Henrich Cheng ◽  
Ching-Feng Weng
Keyword(s):  
Cancer Therapy ◽  
Natural Compounds

scholarly journals Exosome-Based Delivery of Natural Products in Cancer Therapy

2021 ◽  
Vol 9 ◽  
Author(s):  
Hang Song ◽  
Bin Liu ◽  
Bin Dong ◽  
Jing Xu ◽  
Hui Zhou ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Natural Products ◽  
Cancer Therapy ◽  
Natural Product ◽  
Current Knowledge ◽  
Donor Cell ◽  
Natural Compounds ◽  
Cellular Behaviors ◽  
Delivery Vehicles ◽  
Intercellular Communications

A rapidly growing research evidence has begun to shed light on the potential application of exosome, which modulates intercellular communications. As donor cell released vesicles, exosomes could play roles as a regulator of cellular behaviors in up-taken cells, as well as a delivery carrier of drugs for targeted cells. Natural product is an invaluable drug resources and it is used widely as therapeutic agents in cancers. This review summarizes the most recent advances in exosomes as natural product delivery carriers in cancer therapy from the following aspects: composition of exosomes, biogenesis of exosomes, and its functions in cancers. The main focus is the advantages and applications of exosomes for drug delivery in cancer therapy. This review also summarizes the isolation and application of exosomes as delivery carriers of natural products in cancer therapy. The recent progress and challenges of using exosomes as drug delivery vehicles for five representative anti-cancer natural products including paclitaxel, curcumin, doxorubicin, celastrol, and β-Elemene. Based on the discussion on the current knowledge about exosomes as delivery vehicles for drugs and natural compounds to the targeted site, this review delineates the landscape of the recent research, challenges, trends and prospects in exosomes as delivery vehicles for drugs and natural compounds for cancer treatment.

scholarly journals Targeting Autophagy with Natural Compounds in Cancer: A Renewed Perspective from Molecular Mechanisms to Targeted Therapy

2021 ◽  
Vol 12 ◽  
Author(s):  
Qiang Xie ◽  
Yi Chen ◽  
Huidan Tan ◽  
Bo Liu ◽  
Ling-Li Zheng ◽  
...  
Keyword(s):  
Natural Products ◽  
Cancer Therapy ◽  
Signaling Pathways ◽  
Small Molecule ◽  
Molecular Mechanisms ◽  
Biological Activities ◽  
Natural Compounds ◽  
Therapeutic Effects ◽  
Therapeutic Benefits ◽  
Small Molecule Drugs

Natural products are well-characterized to have pharmacological or biological activities that can be of therapeutic benefits for cancer therapy, which also provide an important source of inspiration for discovery of potential novel small-molecule drugs. In the past three decades, accumulating evidence has revealed that natural products can modulate a series of key autophagic signaling pathways and display therapeutic effects in different types of human cancers. In this review, we focus on summarizing some representative natural active compounds, mainly including curcumin, resveratrol, paclitaxel, Bufalin, and Ursolic acid that may ultimately trigger cancer cell death through the regulation of some key autophagic signaling pathways, such as RAS-RAF-MEK-ERK, PI3K-AKT-mTOR, AMPK, ULK1, Beclin-1, Atg5 and p53. Taken together, these inspiring findings would shed light on exploiting more natural compounds as candidate small-molecule drugs, by targeting the crucial pathways of autophagy for the future cancer therapy.

scholarly journals Cancer Therapy Challenge: It Is Time to Look in the “St. Patrick’s Well” of the Nature

2021 ◽  
Vol 22 (19) ◽  
pp. 10380
Author(s):  
Gregorio Bonsignore ◽  
Mauro Patrone ◽  
Federica Grosso ◽  
Simona Martinotti ◽  
Elia Ranzato
Keyword(s):  
Drug Discovery ◽  
Cancer Therapy ◽  
Cause Of Death ◽  
Therapeutic Efficacy ◽  
Natural Compounds ◽  
Chemotherapeutic Drugs ◽  
Therapy Approach ◽  
Drug Concentrations ◽  
Interesting Approach ◽  
Different Origins

Cancer still remains a leading cause of death despite improvements in diagnosis, drug discovery and therapy approach. Therefore, there is a strong need to improve methodologies as well as to increase the number of approaches available. Natural compounds of different origins (i.e., from fungi, plants, microbes, etc.) represent an interesting approach for fighting cancer. In particular, synergistic strategies may represent an intriguing approach, combining natural compounds with classic chemotherapeutic drugs to increase therapeutic efficacy and lower the required drug concentrations. In this review, we focus primarily on those natural compounds utilized in synergistic approached to treating cancer, with particular attention to those compounds that have gained the most research interest.

scholarly journals Progress in Natural Compounds/siRNA Co-delivery Employing Nanovehicles for Cancer Therapy

2020 ◽  
Vol 22 (12) ◽  
pp. 669-700
Author(s):  
Milad Ashrafizadeh ◽  
Ali Zarrabi ◽  
Kiavash Hushmandi ◽  
Farid Hashemi ◽  
Ebrahim Rahmani Moghadam ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Natural Compounds

scholarly journals Current Perspectives of the Applications of Polyphenols and Flavonoids in Cancer Therapy

Molecules ◽  
2020 ◽  
Vol 25 (15) ◽  
pp. 3342 ◽  
Author(s):  
Xavier Montané ◽  
Oliwia Kowalczyk ◽  
Belen Reig-Vano ◽  
Anna Bajek ◽  
Krzysztof Roszkowski ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Human Health ◽  
Food Additives ◽  
Antioxidant Properties ◽  
Natural Compounds ◽  
Future Directions ◽  
Beneficial Effects ◽  
Wide Range ◽  
Cancer Initiation ◽  
Natural Drugs

The development of anticancer therapies that involve natural drugs has undergone exponential growth in recent years. Among the natural compounds that produce beneficial effects on human health, polyphenols have shown potential therapeutic applications in cancer due to their protective functions in plants, their use as food additives, and their excellent antioxidant properties. The possibility of combining conventional drugs—which are usually more aggressive than natural compounds—with polyphenols offers very valuable advantages such as the building of more efficient anticancer therapies with less side effects on human health. This review shows a wide range of trials in which polyphenolic compounds play a crucial role as anticancer medicines alone or in combination with other drugs at different stages of cancer: cancer initiation, promotion, and growth or progression. Moreover, the future directions in applications of various polyphenols in cancer therapy are emphasized.

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