scholarly journals A novel inhibitor of inducible NOS dimerization protects against cytokine-induced rat beta cell dysfunction

2018 ◽  
Vol 175 (17) ◽  
pp. 3470-3485 ◽  
Author(s):  
Linlin Zhong ◽  
Tuan Tran ◽  
Tyler D Baguley ◽  
Sang Jun Lee ◽  
Adam Henke ◽  
...  
Keyword(s):  
Beta Cell ◽  
Beta Cell Dysfunction ◽  
Cell Dysfunction ◽  
Inducible Nos

83-OR: Pancreatic Exocrine to Endocrine Cell Cross Talk Mediates Endoplasmic Reticulum Stress and Beta-Cell Dysfunction in MODY8

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 83-OR
Author(s):  
SEVIM KAHRAMAN ◽  
DANIELLE DIEGISSER ◽  
BENTE B. JOHANSSON ◽  
ANDERS MOLVEN ◽  
ROHIT KULKARNI
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Beta Cell ◽  
Cross Talk ◽  
Endocrine Cell ◽  
Beta Cell Dysfunction ◽  
Cell Dysfunction ◽  
Pancreatic Exocrine

Autoimmunity to insulin, beta cell dysfunction, and development of insulin-dependent diabetes mellitus

Diabetes ◽  
1986 ◽  
Vol 35 (2) ◽  
pp. 139-142 ◽  
Author(s):  
S. Srikanta ◽  
A. T. Ricker ◽  
D. K. McCulloch ◽  
J. S. Soeldner ◽  
G. S. Eisenbarth ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Beta Cell ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Beta Cell Dysfunction ◽  
Cell Dysfunction ◽  
Insulin Dependent

Comparison of Sleeve Gastrectomy and Conservatory Treatment Effect on Biochemical and Hormonal Profile of Obese Type 2 Diabetes Subjects: CREDOR Randomized Controlled Study Results

2017 ◽  
Vol 68 (7) ◽  
pp. 1622-1627 ◽  
Author(s):  
Diana Simona Stefan ◽  
Andrada Mihai ◽  
Daiana Bajko ◽  
Daniela Lixandru ◽  
Laura Petcu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Weight Loss ◽  
Sleeve Gastrectomy ◽  
Beta Cell ◽  
Beta Cell Dysfunction ◽  
Control Group ◽  
Cell Dysfunction ◽  
Randomized Controlled

Metabolic surgery is the most efficacious method for the treatment of morbid obesity and was recently included among the antidiabetes treatments recommended in obese type 2 diabetes (T2D) patients. The aim of this study was to compare in a randomized controlled trial the effect of sleeve gastrectomy (SG) to that of intensive lifestyle intervention plus pharmacologic treatment on some markers of insulin resistance and beta cell function as well as some appetite controlling hormones in a group of male obese T2D subjects. The study groups comprised 20 subjects for SG and 21 control subjects. Fasting blood glucose, insulin, proinsulin, adiponectin, leptin, ghrelin, HOMA-IR, HOMA-%B, proinsulin-to-insulin ratio and proinsulin-to-adiponectin ratio were evaluated at baseline and after one year follow-up. Overall, patients in the SG group lost 78.98% of excess weight loss (%EWL) in comparison with 9.45% in the control group. This was accompanied by a significant improvement of insulin resistance markers, including increase of adiponectin and decrease of HOMA-IR, while no changes were recorded in the control group. Weight loss was also associated with a significant improvement of proinsulin-to-insulin and proinsulin-to-adiponectin ratio, both surrogate markers of beta cell dysfunction. These also improved in the control group, but were only marginally significant. Our findings suggest that improved insulin resistance and decreased beta cell dysfunction after sleeve gastrectomy might explain diabetes remission associated with metabolic surgery.

scholarly journals Effects of DHMEQ, a Novel Nuclear Factor-κB Inhibitor, on Beta Cell Dysfunction in INS-1 Cells

2008 ◽  
Vol 55 (2) ◽  
pp. 433-438 ◽  
Author(s):  
Yoshifumi SAISHO ◽  
Hiroshi HIROSE ◽  
Chihiro HORIMAI ◽  
Kiichi MIYASHITA ◽  
Izumi TAKEI ◽  
...  
Keyword(s):  
Beta Cell ◽  
Nuclear Factor Κb ◽  
Beta Cell Dysfunction ◽  
Nuclear Factor ◽  
Cell Dysfunction

scholarly journals Selective inhibition of 12-lipoxygenase protects islets and beta cells from inflammatory cytokine-mediated beta cell dysfunction

Diabetologia ◽  
2014 ◽  
Vol 58 (3) ◽  
pp. 549-557 ◽  
Author(s):  
David A. Taylor-Fishwick ◽  
Jessica Weaver ◽  
Lindsey Glenn ◽  
Norine Kuhn ◽  
Ganesha Rai ◽  
...  
Keyword(s):  
Beta Cell ◽  
Beta Cells ◽  
Inflammatory Cytokine ◽  
Selective Inhibition ◽  
Beta Cell Dysfunction ◽  
Cell Dysfunction ◽  
12 Lipoxygenase

scholarly journals Balsamic Vinegar Improves High Fat-Induced Beta Cell Dysfunction via Beta Cell ABCA1

2012 ◽  
Vol 36 (4) ◽  
pp. 275 ◽  
Author(s):  
Hannah Seok ◽  
Ji Young Lee ◽  
Eun Mi Park ◽  
Se Eun Park ◽  
Jae Hyuk Lee ◽  
...  
Keyword(s):  
Beta Cell ◽  
Beta Cell Dysfunction ◽  
High Fat ◽  
Cell Dysfunction ◽  
Balsamic Vinegar

Beta Cell Dysfunction, Oxidative Stress and S6K1 Activation in Pancreas in the Zucker Obese Rat Model

2011 ◽  
pp. P2-480-P2-480
Author(s):  
Guido Lastra ◽  
Charles B Krueger ◽  
Camila Manrique ◽  
James R Sowers
Keyword(s):  
Oxidative Stress ◽  
Beta Cell ◽  
Rat Model ◽  
Beta Cell Dysfunction ◽  
Cell Dysfunction
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