83-OR: Pancreatic Exocrine to Endocrine Cell Cross Talk Mediates Endoplasmic Reticulum Stress and Beta-Cell Dysfunction in MODY8

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 83-OR
Author(s):  
SEVIM KAHRAMAN ◽  
DANIELLE DIEGISSER ◽  
BENTE B. JOHANSSON ◽  
ANDERS MOLVEN ◽  
ROHIT KULKARNI
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Beta Cell ◽  
Cross Talk ◽  
Endocrine Cell ◽  
Beta Cell Dysfunction ◽  
Cell Dysfunction ◽  
Pancreatic Exocrine

Progressive endoplasmic reticulum stress over time due to human insulin gene mutation contributes to pancreatic beta cell dysfunction

Diabetologia ◽  
2021 ◽  
Vol 64 (11) ◽  
pp. 2534-2549
Author(s):  
Nur Shabrina Amirruddin ◽  
Wei Xuan Tan ◽  
Yaw Sing Tan ◽  
Daphne Su-Lyn Gardner ◽  
Yong Mong Bee ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Beta Cell ◽  
Gene Mutation ◽  
Human Insulin ◽  
Pancreatic Beta Cell ◽  
Beta Cell Dysfunction ◽  
Cell Dysfunction ◽  
Human Insulin Gene ◽  
Over Time

scholarly journals Glucose-induced beta cell dysfunction in vivo in rats: link between oxidative stress and endoplasmic reticulum stress

Diabetologia ◽  
2012 ◽  
Vol 55 (5) ◽  
pp. 1366-1379 ◽  
Author(s):  
C. Tang ◽  
K. Koulajian ◽  
I. Schuiki ◽  
L. Zhang ◽  
T. Desai ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Beta Cell ◽  
Beta Cell Dysfunction ◽  
Cell Dysfunction

Prednisolone-induced beta cell dysfunction is associated with impaired endoplasmic reticulum homeostasis in INS-1E cells

2011 ◽  
Vol 23 (11) ◽  
pp. 1708-1715 ◽  
Author(s):  
Margot M.L. Linssen ◽  
Daniel H. van Raalte ◽  
Erik J.M. Toonen ◽  
Wynand Alkema ◽  
Gerard C. van der Zon ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Beta Cell ◽  
Beta Cell Dysfunction ◽  
Cell Dysfunction

scholarly journals Endoplasmic Reticulum Stress and Insulin Biosynthesis: A Review

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Mi-Kyung Kim ◽  
Hye-Soon Kim ◽  
In-Kyu Lee ◽  
Keun-Gyu Park
Keyword(s):  
Diabetes Mellitus ◽  
Endoplasmic Reticulum ◽  
Beta Cell ◽  
Er Stress ◽  
Pancreatic Beta Cells ◽  
Pancreatic Beta Cell ◽  
Insulin Biosynthesis ◽  
Beta Cell Dysfunction ◽  
Cell Dysfunction ◽  
The Relationship

Insulin resistance and pancreatic beta cell dysfunction are major contributors to the pathogenesis of diabetes. Various conditions play a role in the pathogenesis of pancreatic beta cell dysfunction and are correlated with endoplasmic reticulum (ER) stress. Pancreatic beta cells are susceptible to ER stress. Many studies have shown that increased ER stress induces pancreatic beta cell dysfunction and diabetes mellitus using genetic models of ER stress and by various stimuli. There are many reports indicating that ER stress plays an important role in the impairment of insulin biosynthesis, suggesting that reduction of ER stress could be a therapeutic target for diabetes. In this paper, we reviewed the relationship between ER stress and diabetes and how ER stress controls insulin biosynthesis.

Autoimmunity to insulin, beta cell dysfunction, and development of insulin-dependent diabetes mellitus

Diabetes ◽  
1986 ◽  
Vol 35 (2) ◽  
pp. 139-142 ◽  
Author(s):  
S. Srikanta ◽  
A. T. Ricker ◽  
D. K. McCulloch ◽  
J. S. Soeldner ◽  
G. S. Eisenbarth ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Beta Cell ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Beta Cell Dysfunction ◽  
Cell Dysfunction ◽  
Insulin Dependent

Comparison of Sleeve Gastrectomy and Conservatory Treatment Effect on Biochemical and Hormonal Profile of Obese Type 2 Diabetes Subjects: CREDOR Randomized Controlled Study Results

2017 ◽  
Vol 68 (7) ◽  
pp. 1622-1627 ◽  
Author(s):  
Diana Simona Stefan ◽  
Andrada Mihai ◽  
Daiana Bajko ◽  
Daniela Lixandru ◽  
Laura Petcu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Weight Loss ◽  
Sleeve Gastrectomy ◽  
Beta Cell ◽  
Beta Cell Dysfunction ◽  
Control Group ◽  
Cell Dysfunction ◽  
Randomized Controlled

Metabolic surgery is the most efficacious method for the treatment of morbid obesity and was recently included among the antidiabetes treatments recommended in obese type 2 diabetes (T2D) patients. The aim of this study was to compare in a randomized controlled trial the effect of sleeve gastrectomy (SG) to that of intensive lifestyle intervention plus pharmacologic treatment on some markers of insulin resistance and beta cell function as well as some appetite controlling hormones in a group of male obese T2D subjects. The study groups comprised 20 subjects for SG and 21 control subjects. Fasting blood glucose, insulin, proinsulin, adiponectin, leptin, ghrelin, HOMA-IR, HOMA-%B, proinsulin-to-insulin ratio and proinsulin-to-adiponectin ratio were evaluated at baseline and after one year follow-up. Overall, patients in the SG group lost 78.98% of excess weight loss (%EWL) in comparison with 9.45% in the control group. This was accompanied by a significant improvement of insulin resistance markers, including increase of adiponectin and decrease of HOMA-IR, while no changes were recorded in the control group. Weight loss was also associated with a significant improvement of proinsulin-to-insulin and proinsulin-to-adiponectin ratio, both surrogate markers of beta cell dysfunction. These also improved in the control group, but were only marginally significant. Our findings suggest that improved insulin resistance and decreased beta cell dysfunction after sleeve gastrectomy might explain diabetes remission associated with metabolic surgery.

Effect of the cross-talk between autophagy and endoplasmic reticulum stress on Mn-induced alpha-synuclein oligomerization

2017 ◽  
Vol 33 (3) ◽  
pp. 315-324 ◽  
Author(s):  
Chang Liu ◽  
Dong-Ying Yan ◽  
Xuan Tan ◽  
Zhuo Ma ◽  
Can Wang ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Cross Talk ◽  
Alpha Synuclein ◽  
The Cross

scholarly journals Effects of DHMEQ, a Novel Nuclear Factor-κB Inhibitor, on Beta Cell Dysfunction in INS-1 Cells

2008 ◽  
Vol 55 (2) ◽  
pp. 433-438 ◽  
Author(s):  
Yoshifumi SAISHO ◽  
Hiroshi HIROSE ◽  
Chihiro HORIMAI ◽  
Kiichi MIYASHITA ◽  
Izumi TAKEI ◽  
...  
Keyword(s):  
Beta Cell ◽  
Nuclear Factor Κb ◽  
Beta Cell Dysfunction ◽  
Nuclear Factor ◽  
Cell Dysfunction
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