scholarly journals Functional plasticity of the N/OFQ-NOP receptor system determines analgesic properties of NOP receptor agonists

2014 ◽  
Vol 171 (16) ◽  
pp. 3777-3800 ◽  
Author(s):  
W Schröder ◽  
D G Lambert ◽  
M C Ko ◽  
T Koch
Keyword(s):  
Nop Receptor ◽  
Functional Plasticity ◽  
Receptor System ◽  
Receptor Agonists

Structure-Based SAR in the Design of Selective or Bifunctional Nociceptin (NOP) Receptor Agonists

2021 ◽  
Vol 23 (3) ◽  
Author(s):  
Michael E. Meyer ◽  
Arpit Doshi ◽  
Dennis Yasuda ◽  
Nurulain T. Zaveri
Keyword(s):  
Nop Receptor ◽  
Receptor Agonists

Cardiovascular and renal effects of novel non‐peptide nociceptin opioid peptide (NOP) receptor agonists

2021 ◽  
Author(s):  
Ian B. Denys ◽  
Juan Gao ◽  
Jane C. Sutphen ◽  
Nurulain T. Zaveri ◽  
Daniel R. Kapusta
Keyword(s):  
Opioid Peptide ◽  
Nop Receptor ◽  
Renal Effects ◽  
Receptor Agonists

Modulation of the NOP receptor signaling affects resilience to acute stress

2019 ◽  
Vol 33 (12) ◽  
pp. 1540-1549 ◽  
Author(s):  
Victor A D Holanda ◽  
Salvatore Pacifico ◽  
Joaquim Azevedo Neto ◽  
Luca Finetti ◽  
Bruno Lobão-Soares ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Stress ◽  
Behavioral Effects ◽  
Emotional States ◽  
Receptor Signaling ◽  
Nop Receptor ◽  
Orphanin Fq ◽  
Receptor System ◽  
Electric Footshock ◽  
First Time

Background: The peptide nociceptin/orphanin FQ (N/OFQ) and its receptor (NOP) are implicated in the modulation of emotional states. Previous human and rodent findings support NOP antagonists as antidepressants. However, the role played by the N/OFQ–NOP receptor system in resilience to stress is unclear. Aims: The present study investigated the effects of activation or blockade of NOP receptor signaling before exposure to acute stress. Methods: The behavioral effects of the administration before stress of the NOP agonists Ro 65-6570 (0.01–1 mg/kg) and MCOPPB (0.1–10 mg/kg), and the NOP antagonist SB-612111 (1–10 mg/kg) were assessed in mice exposed to inescapable electric footshock and forced swim as stressors. The behavioral phenotype of mice lacking the NOP receptor (NOP(-/-)) exposed to inescapable electric footshock was also investigated. Results: The activation of NOP receptor signaling with the agonists increased the percentage of mice developing helpless behavior and facilitated immobile posture. In contrast, the blockade of NOP receptor reduced the acquisition of depressive-like phenotypes, and similar resistance to develop helpless behaviors was observed in NOP(-/-) mice. Under the same stressful conditions, the antidepressant nortriptyline (20 mg/kg) did not change the acquisition of helpless behavior and immobile posture. Conclusions: These findings support the view that NOP activation during acute stress facilitates the development of depressive-related behaviors, whereas NOP blockade has a protective outcome. This study showed for first time that NOP antagonists are worthy of investigation as preemptive treatments in patients with severe risk factors for depression.

scholarly journals A key role for the N/OFQ-NOP receptor system in modulating nicotine taking in a model of nicotine and alcohol co-administration

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Andrea Cippitelli ◽  
Jennifer Schoch ◽  
Ginamarie Debevec ◽  
Gloria Brunori ◽  
Nurulain T. Zaveri ◽  
...  
Keyword(s):  
Nop Receptor ◽  
Receptor System

Blockade of the nociceptin/orphanin FQ/NOP receptor system in the rat ventrolateral periaqueductal gray potentiates DAMGO analgesia

Peptides ◽  
2007 ◽  
Vol 28 (7) ◽  
pp. 1441-1446 ◽  
Author(s):  
Giovanna M. Scoto ◽  
Giuseppina Aricò ◽  
Simone Ronsisvalle ◽  
Carmela Parenti
Keyword(s):  
Periaqueductal Gray ◽  
Nop Receptor ◽  
Orphanin Fq ◽  
Receptor System
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