scholarly journals A key role for the N/OFQ-NOP receptor system in modulating nicotine taking in a model of nicotine and alcohol co-administration

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Andrea Cippitelli ◽  
Jennifer Schoch ◽  
Ginamarie Debevec ◽  
Gloria Brunori ◽  
Nurulain T. Zaveri ◽  
...  
Keyword(s):  
Nop Receptor ◽  
Receptor System

Modulation of the NOP receptor signaling affects resilience to acute stress

2019 ◽  
Vol 33 (12) ◽  
pp. 1540-1549 ◽  
Author(s):  
Victor A D Holanda ◽  
Salvatore Pacifico ◽  
Joaquim Azevedo Neto ◽  
Luca Finetti ◽  
Bruno Lobão-Soares ◽  
...  
Keyword(s):  
Risk Factors ◽  
Acute Stress ◽  
Behavioral Effects ◽  
Emotional States ◽  
Receptor Signaling ◽  
Nop Receptor ◽  
Orphanin Fq ◽  
Receptor System ◽  
Electric Footshock ◽  
First Time

Background: The peptide nociceptin/orphanin FQ (N/OFQ) and its receptor (NOP) are implicated in the modulation of emotional states. Previous human and rodent findings support NOP antagonists as antidepressants. However, the role played by the N/OFQ–NOP receptor system in resilience to stress is unclear. Aims: The present study investigated the effects of activation or blockade of NOP receptor signaling before exposure to acute stress. Methods: The behavioral effects of the administration before stress of the NOP agonists Ro 65-6570 (0.01–1 mg/kg) and MCOPPB (0.1–10 mg/kg), and the NOP antagonist SB-612111 (1–10 mg/kg) were assessed in mice exposed to inescapable electric footshock and forced swim as stressors. The behavioral phenotype of mice lacking the NOP receptor (NOP(-/-)) exposed to inescapable electric footshock was also investigated. Results: The activation of NOP receptor signaling with the agonists increased the percentage of mice developing helpless behavior and facilitated immobile posture. In contrast, the blockade of NOP receptor reduced the acquisition of depressive-like phenotypes, and similar resistance to develop helpless behaviors was observed in NOP(-/-) mice. Under the same stressful conditions, the antidepressant nortriptyline (20 mg/kg) did not change the acquisition of helpless behavior and immobile posture. Conclusions: These findings support the view that NOP activation during acute stress facilitates the development of depressive-related behaviors, whereas NOP blockade has a protective outcome. This study showed for first time that NOP antagonists are worthy of investigation as preemptive treatments in patients with severe risk factors for depression.

Blockade of the nociceptin/orphanin FQ/NOP receptor system in the rat ventrolateral periaqueductal gray potentiates DAMGO analgesia

Peptides ◽  
2007 ◽  
Vol 28 (7) ◽  
pp. 1441-1446 ◽  
Author(s):  
Giovanna M. Scoto ◽  
Giuseppina Aricò ◽  
Simone Ronsisvalle ◽  
Carmela Parenti
Keyword(s):  
Periaqueductal Gray ◽  
Nop Receptor ◽  
Orphanin Fq ◽  
Receptor System

scholarly journals Chronic high-NaCl intake prolongs the cardiorenal responses to central N/OFQ and produces regional changes in the endogenous brain NOP receptor system

2009 ◽  
Vol 296 (2) ◽  
pp. R280-R288 ◽  
Author(s):  
Richard D. Wainford ◽  
Daniel R. Kapusta
Keyword(s):  
G Protein ◽  
Urine Output ◽  
Salt Intake ◽  
Ventrolateral Medulla ◽  
Receptor Density ◽  
Nop Receptor ◽  
Sprague Dawley ◽  
Receptor System ◽  
Intracerebroventricular Infusion ◽  
High Salt Intake

Intracerebroventricular nociceptin/orphanin FQ (N/OFQ) produces cardiovascular depressor, diuretic, and renal sympathoinhibitory responses in conscious rats. These studies examined how a chronic high-NaCl intake alters these peptide-evoked responses and the activity of the endogenous central N/OFQ peptide (NOP) receptor system. In normotensive Sprague-Dawley rats fed a chronic (3-wk) high (8%)-NaCl diet, intracerebroventricular N/OFQ (5.5 nmol) produced prolonged bradycardic, hypotensive, and diuretic responses but failed to suppress renal sympathetic nerve activity. In a separate group of rats maintained on a high-NaCl diet, intracerebroventricular infusion of the NOP receptor antagonist UFP-101 significantly decreased urine output. At the tissue level, high-NaCl treatment of rats significantly increased NOP receptor density, without altering endogenous N/OFQ peptide levels in whole hypothalamus (control, 712 ± 35 fmol/mg vs. 8% NaCl, 883 ± 49 fmol/mg, P < 0.05) and paraventricular nucleus. Furthermore, in the hypothalamus, basal GTPγS binding was increased without altering the sensitivity of N/OFQ-stimulated G protein coupling. In contrast, in whole medulla and the ventrolateral medulla (VLM), high-NaCl treatment decreased NOP receptor density (medulla: control, 1,473 ± 131 fmol/mg vs. 8% NaCl, 327 ± 31 fmol/mg, P < 0.05) and endogenous N/OFQ peptide levels (medulla: control, 35.3 ± 2 fmol/mg vs. 8% NaCl, 11.9 ± 3 fmol/mg, P < 0.05), while increasing the sensitivity of G protein signaling pathways to N/OFQ stimulation. Together, these findings suggest that during a chronic high-salt intake, regional changes in the activity of the N/OFQ-NOP system in the brain may contribute to the tonic regulation of cardiovascular function and urine output and to the altered physiological responses to exogenous central N/OFQ.

Nociceptin/Orphanin FQ-NOP Receptor System in Inflammatory and Immune-Mediated Diseases

2015 ◽  
pp. 241-266 ◽  
Author(s):  
Elaine C. Gavioli ◽  
Iris Ucella de Medeiros ◽  
Marta C. Monteiro ◽  
Girolamo Calo ◽  
Pedro R.T. Romão
Keyword(s):  
Nop Receptor ◽  
Orphanin Fq ◽  
Receptor System ◽  
Immune Mediated

The Nociceptin/Orphanin Fq Nop Receptor System as a Therapeutic Target for the Treatment of Substance Use and Stress Related Disorders: Preclinical Evidence

2020 ◽  
Vol 87 (9) ◽  
pp. S80
Author(s):  
Roberto Ciccocioppo ◽  
Anna Maria Borruto ◽  
Federica Benvenuti ◽  
Michele Petrella ◽  
Laura Soverchia ◽  
...  
Keyword(s):  
Substance Use ◽  
Therapeutic Target ◽  
Nop Receptor ◽  
Orphanin Fq ◽  
Receptor System
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