scholarly journals Molecular mechanism of action of bisphenol and bisphenol A mediated by oestrogen receptor alpha in growth and apoptosis of breast cancer cells

2013 ◽  
Vol 169 (1) ◽  
pp. 167-178 ◽  
Author(s):  
S Sengupta ◽  
I Obiorah ◽  
PY Maximov ◽  
R Curpan ◽  
VC Jordan
Keyword(s):  
Breast Cancer ◽  
Bisphenol A ◽  
Cancer Cells ◽  
Molecular Mechanism ◽  
Mechanism Of Action ◽  
Oestrogen Receptor ◽  
Breast Cancer Cells ◽  
Receptor Alpha ◽  
Oestrogen Receptor Alpha ◽  
Molecular Mechanism Of Action

scholarly journals Transcriptional implications of intragenic DNA methylation in the oestrogen receptor alpha gene in breast cancer cells and tissues

BMC Cancer ◽  
2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Natalie S Shenker ◽  
Kirsty J Flower ◽  
Charlotte S Wilhelm-Benartzi ◽  
Wei Dai ◽  
Emma Bell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Methylation ◽  
Cancer Cells ◽  
Oestrogen Receptor ◽  
Breast Cancer Cells ◽  
Receptor Alpha ◽  
Oestrogen Receptor Alpha ◽  
Alpha Gene

scholarly journals Hormone-Like Effects of Bisphenol A on p53 and Estrogen Receptor Alpha in Breast Cancer Cells

2019 ◽  
Vol 8 (1) ◽  
pp. 169-184 ◽  
Author(s):  
Victoria Lloyd ◽  
Mia Morse ◽  
Betsy Purakal ◽  
Jordan Parker ◽  
Paige Benard ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Bisphenol A ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Estrogen Receptor Alpha ◽  
Receptor Alpha

scholarly journals Conjugation of palbociclib with MHI-148 has an increased cytotoxic effect for breast cancer cells and an altered mechanism of action

2021 ◽  
Author(s):  
Euphemia Leung ◽  
Petr Tomek ◽  
Moana Tercel ◽  
Johannes Reynisson ◽  
Thomas In Hyeup Park ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Endocrine Therapy ◽  
Mechanism Of Action ◽  
Oestrogen Receptor ◽  
Breast Cancer Cells ◽  
Cytotoxic Effect ◽  
Near Infrared ◽  
Triple Negative ◽  
Mammalian Cell Lines

The CDK4/6 inhibitor palbociclib, combined with endocrine therapy, has been shown to be effective in postmenopausal women with oestrogen receptor positive, HER2-negative advanced or metastatic breast cancer. However, palbociclib is not as effective in the highly aggressive triple-negative breast cancer that lacks sensitivity to chemotherapy or endocrine therapy. We hypothesized that conjugation of the near-infrared dye MHI-148 with palbociclib can produce a potential theranostic in triple-negative as well as oestrogen receptor positive breast cancer cells. In our study, the conjugate was found to have enhanced activity in all mammalian cell lines tested in vitro. However, the conjugate was cytotoxic and did not induce G1 cell cycle arrest in breast cancer cells suggesting the mechanism of action differed from the parent compound palbociclib. The study highlights the importance of investigating the mechanism of conjugates of near-infrared dyes to therapeutic compounds as conjugation can potentially result in a change of mechanism or target, with an enhanced cytotoxic effect in this case.

Sign in / Sign up

Export Citation Format

Share Document