Cell length growth patterns in fission yeast reveal a novel size control mechanism operating in late G2 phase

2016 ◽  
Vol 108 (9) ◽  
pp. 259-277 ◽  
Author(s):  
Anna Horváth ◽  
Anna Rácz-Mónus ◽  
Peter Buchwald ◽  
Ákos Sveiczer
Keyword(s):  
Fission Yeast ◽  
Control Mechanism ◽  
Size Control ◽  
Growth Patterns ◽  
Cell Length ◽  
Length Growth ◽  
G2 Phase

scholarly journals Cell length growth in fission yeast: an analysis of its bilinear character and the nature of its rate change transition

2013 ◽  
Vol 13 (7) ◽  
pp. 635-649 ◽  
Author(s):  
Anna Horváth ◽  
Anna Rácz-Mónus ◽  
Peter Buchwald ◽  
Ákos Sveiczer
Keyword(s):  
Fission Yeast ◽  
Rate Change ◽  
Cell Length ◽  
Length Growth

scholarly journals Cell Length Growth in the Fission Yeast Cell Cycle: Is It (Bi)linear or (Bi)exponential?

Processes ◽  
2021 ◽  
Vol 9 (9) ◽  
pp. 1533
Author(s):  
Benedek Pesti ◽  
Zsófia Nagy ◽  
László Papp ◽  
Matthias Sipiczki ◽  
Ákos Sveiczer
Keyword(s):  
Fission Yeast ◽  
Mitotic Cycle ◽  
Model Fitting ◽  
Model Organism ◽  
Eukaryotic Cell ◽  
Growth Patterns ◽  
Wild Type ◽  
Length Growth ◽  
Bilinear Models ◽  
Bilinear Functions

Fission yeast is commonly used as a model organism in eukaryotic cell growth studies. To describe the cells’ length growth patterns during the mitotic cycle, different models have been proposed previously as linear, exponential, bilinear and biexponential ones. The task of discriminating among these patterns is still challenging. Here, we have analyzed 298 individual cells altogether, namely from three different steady-state cultures (wild-type, wee1-50 mutant and pom1Δ mutant). We have concluded that in 190 cases (63.8%) the bilinear model was more adequate than either the linear or the exponential ones. These 190 cells were further examined by separately analyzing the linear segments of the best fitted bilinear models. Linear and exponential functions have been fitted to these growth segments to determine whether the previously fitted bilinear functions were really correct. The majority of these growth segments were found to be linear; nonetheless, a significant number of exponential ones were also detected. However, exponential ones occurred mainly in cases of rather short segments (<40 min), where there were not enough data for an accurate model fitting. By contrast, in long enough growth segments (≥40 min), linear patterns highly dominated over exponential ones, verifying that overall growth is probably bilinear.

scholarly journals Determination of organ size: a need to focus on growth rate, not size

2020 ◽  
Vol 64 (4-5-6) ◽  
pp. 299-318
Author(s):  
Carmen M.A. Coelho
Keyword(s):  
Control Mechanism ◽  
Growth Control ◽  
Size Control ◽  
Organ Size ◽  
Cell Competition ◽  
The Past ◽  
Mechanistic Basis ◽  
Regulation Of Growth ◽  
Correct Size

The regulation of growth and the determination of organ-size in animals is an area of research that has received much attention during the past two and a half decades. Classic regeneration and cell-competition studies performed during the last century suggested that for size to be determined, organ-size is sensed and this sense of size feeds back into the growth control mechanism such that growth stops at the “correct” size. Recent work using Drosophila imaginal discs as a system has provided a particularly detailed cellular and molecular understanding of growth. Yet, a clear mechanistic basis for size-sensing has not emerged. I re-examine these studies from a different perspective and ask whether there is scope for alternate modes of size control in which size does not need to be sensed.

CAMBIAL BEHAVIOR WITH REFERENCE TO CELL LENGTH AND RING WIDTH IN PINUS STROBUS L.

1962 ◽  
Vol 40 (8) ◽  
pp. 1057-1062 ◽  
Author(s):  
M. W. Bannan
Keyword(s):  
Inverse Relationship ◽  
Ring Width ◽  
Pinus Strobus ◽  
Growth Patterns ◽  
Cell Length ◽  
Annual Rings ◽  
Forest Types ◽  
Thuja Occidentalis ◽  
Cambial Cells ◽  
Individual Trees

The relationships between width of annual rings, length of wood cells, and frequency of anticlinal (multiplicative) divisions in fusiform cambial cells were studied by reference to trees of various growth patterns. The trees selected ranged from 8 to 20 in. diameter and included both open-grown specimens with branches close to the ground and forest types with tall, slender shafts. Much fluctuation was noted among individual trees, but in general there was, in the peripheral growth, an inverse relationship between length of wood cells and width of annual rings. The frequency of anticlinal divisions in the cambium remained at a more or less uniform rate in trees with rings from 1.5 to 5 mm wide, but rose sharply when ring width fell below 1.3 mm. This was in contrast to the situation observed earlier in Thuja occidentalis where the rise in frequency of anticlinal divisions was slight and occurred only in trees with rings less than 0.3 mm wide.

scholarly journals Size-Selected Synthesis of PtRu Nano-Catalysts:  Reaction and Size Control Mechanism

2004 ◽  
Vol 126 (25) ◽  
pp. 8028-8037 ◽  
Author(s):  
Christina Bock ◽  
Chantal Paquet ◽  
Martin Couillard ◽  
Gianluigi A. Botton ◽  
Barry R. MacDougall
Keyword(s):  
Control Mechanism ◽  
Size Control ◽  
Nano Catalysts

Understanding the Size Control Mechanism for Pt/C Catalysts Made Using the Polyol Method

2013 ◽  
pp. 165-172
Author(s):  
P.C. Favilla ◽  
J.J. Acosta ◽  
C.E. Schvezov ◽  
D.J. Sercovich ◽  
J.R. Collet-Lacoste
Keyword(s):  
Control Mechanism ◽  
Size Control ◽  
Polyol Method

Strongly oversized fission yeast cells lack any size control and tend to grow linearly rather than bilinearly

Yeast ◽  
2020 ◽  
Author(s):  
Zsófia Nagy ◽  
Anna Medgyes‐Horváth ◽  
Eszter Vörös ◽  
Ákos Sveiczer
Keyword(s):  
Fission Yeast ◽  
Size Control ◽  
Yeast Cells

Size control mechanism of ZnO nanoparticles obtained in microwave solvothermal synthesis

2018 ◽  
Vol 29 (6) ◽  
pp. 065601 ◽  
Author(s):  
Jacek Wojnarowicz ◽  
Tadeusz Chudoba ◽  
Iwona Koltsov ◽  
Stanislaw Gierlotka ◽  
Sylwia Dworakowska ◽  
...  
Keyword(s):  
Zno Nanoparticles ◽  
Solvothermal Synthesis ◽  
Control Mechanism ◽  
Size Control

scholarly journals Cortical regulation of cell size by a sizer cdr2p

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Kally Z Pan ◽  
Timothy E Saunders ◽  
Ignacio Flor-Parra ◽  
Martin Howard ◽  
Fred Chang
Keyword(s):  
Cell Division ◽  
Protein Kinase ◽  
Cell Surface ◽  
Surface Area ◽  
Control Mechanism ◽  
Size Control ◽  
Mitotic Entry ◽  
Medial Cortex ◽  
Peripheral Membrane Protein ◽  
Dose Dependent

Cells can, in principle, control their size by growing to a specified size before commencing cell division. How any cell actually senses its own size remains poorly understood. The fission yeast Schizosaccharomyces pombe are rod-shaped cells that grow to ∼14 µm in length before entering mitosis. In this study, we provide evidence that these cells sense their surface area as part of this size control mechanism. We show that cells enter mitosis at a certain surface area, as opposed to a certain volume or length. A peripheral membrane protein kinase cdr2p has properties of a dose-dependent ‘sizer’ that controls mitotic entry. As cells grow, the local cdr2p concentration in nodes at the medial cortex accumulates as a measure of cell surface area. Our findings, which challenge a previously proposed pom1p gradient model, lead to a new model in which cells sense their size by using cdr2p to probe the surface area over the whole cell and relay this information to the medial cortex.

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