A longitudinal study evaluating interim assessment of neoadjuvant chemotherapy for bladder cancer

2021 ◽  
Author(s):  
Marc A. Furrer ◽  
Nathan Papa ◽  
Sandro Luetolf ◽  
Beat Roth ◽  
Marcus Cumberbatch ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Longitudinal Study ◽  
Neoadjuvant Chemotherapy ◽  
Interim Assessment

scholarly journals A Longitudinal Study of the Bladder Cancer Applying a State-Space Model with Non-Exponential Staying Time in States

Mathematics ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 363
Author(s):  
Delia Montoro-Cazorla ◽  
Rafael Pérez-Ocón ◽  
Alicia Pereira das Neves-Yedig
Keyword(s):  
Bladder Cancer ◽  
Longitudinal Study ◽  
State Space Model ◽  
Exponential Distributions ◽  
Significance Level ◽  
Phase Type Distributions ◽  
And Performance ◽  
The Times ◽  
Comparison Of The Results ◽  
Staying Time

A longitudinal study for 847 bladder cancer patients for a period of fifteen years is presented. After the first surgery, the patients undergo successive ones (recurrences). A state-model is selected for analyzing the evolution of the cancer, based on the distribution of the times between recurrences. These times do not follow exponential distributions, and are approximated by phase-type distributions. Under these conditions, a multidimensional Markov process governs the evolution of the disease. The survival probability and mean times in the different states (levels) of the disease are calculated empirically and also by applying the Markov model, the comparison of the results indicate that the model is well-fitted to the data to an acceptable significance level of 0.05. Two sub-cohorts are well-differenced: those reaching progression (the bladder is removed) and those that do not. These two cases are separately studied and performance measures calculated, and the comparison reveals details about the characteristics of the patients in these groups.

scholarly journals Efficient delivery of radical cystectomy after neoadjuvant chemotherapy for muscle-invasive bladder cancer

Cancer ◽  
2011 ◽  
Vol 118 (1) ◽  
pp. 44-53 ◽  
Author(s):  
Ajjai S. Alva ◽  
Christopher T. Tallman ◽  
Chang He ◽  
Maha H. Hussain ◽  
Khaled Hafez ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Radical Cystectomy ◽  
Invasive Bladder Cancer ◽  
Muscle Invasive Bladder Cancer ◽  
Efficient Delivery ◽  
Muscle Invasive
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