Therapeutic effects of endoscopic ablation in patients with Hunner type interstitial cystitis

2018 ◽  
Vol 121 (4) ◽  
pp. 659-666 ◽  
Author(s):  
Kwang Jin Ko ◽  
Hyunwoo Chung ◽  
Yoon Seok Suh ◽  
Sin Woo Lee ◽  
Tae Heon Kim ◽  
...  
Keyword(s):  
Interstitial Cystitis ◽  
Therapeutic Effects ◽  
Endoscopic Ablation

scholarly journals Endoscopic ablation of Hunner’s lesions in interstitial cystitis patients

2013 ◽  
Vol 3 (6) ◽  
pp. 473 ◽  
Author(s):  
Ryan A. Payne ◽  
R. Corey O’Connor ◽  
Margarita Kressin ◽  
Michael L. Guralnick
Keyword(s):  
Interstitial Cystitis ◽  
Chart Review ◽  
Prise En Charge ◽  
Cystite Interstitielle ◽  
Symptomatic Recurrence ◽  
Endoscopic Ablation ◽  
Pathology Reports

Introduction: We report our experience with endoscopic ablationof Hunner’s lesions in women with interstitial cystitis (IC).Methods: A chart review was performed on 14 patients with ICsymptoms who were identified to have bladder lesions and underwentendoscopic ablation. A Hunner’s lesion was identified asan area of erythema that reproduced the patients’ pain when touchedby the cystoscope. Pathology reports were reviewed and improvementin pain was used as the main outcome measure.Results: Of the 14 patients, 12 had more than 50% symptomaticimprovement and 8 patients reported 100% improvement. Meanimprovement was 76%. In all patients who improved, the biopsyspecimen showed inflammatory cystitis, often with epithelialdenudation. Four patients had symptomatic recurrence, but allhad improvement after repeat ablation.Conclusion: Endoscopic ablation of Hunner’s lesions improves symptomsin IC patients. Recurrence of symptoms should prompt repeatcystoscopy to identify recurrent lesions, as repeat ablation offerssymptomatic improvement.Introduction : L’article fait état de notre expérience concernantl’ablation endoscopique d’ulcères de Hunner chez des femmesatteintes de cystite interstitielle (CI).Méthodologie : On a mené un examen des dossiers de 14 patientesprésentant des symptômes de CI chez qui des lésions vésicalesavaient été observées et traitées par ablation endoscopique. Unulcère de Hunner était défini comme une zone d’érythème reproduisantla douleur décrite par la patiente lorsque cette zone étaittouchée à l’aide du cystoscope. Les rapports de pathologie ontété examinés et la réduction de la douleur a été utilisée commeprincipal critère d’évaluation.Résultats : Sur les 14 patientes, 12 ont présenté une réduction supérieureà 50 % des symptômes et 8 ont signalé une réduction de 100 %. Letaux moyen de réduction était de 76 %. Chez toutes les patientesayant signalé une réduction des symptômes, l’échantillon de tissuprélevé par biopsie montrait la présence de cystite inflammatoire,souvent accompagnée de dénudation épithéliale. Quatre patientesont signalé une réapparition des symptômes, mais une nouvelle ablationa permis de réduire encore une fois les symptômes.Conclusion : L’ablation endoscopique des ulcères de Hunner entraîneune réduction des symptômes en présence de CI. La réapparitiondes symptômes devrait être prise en charge par une nouvelle cystoscopieafin de repérer les nouvelles lésions; une nouvelle ablationpermet de soulager les symptômes.

scholarly journals Use of Intravesical Injections of Platelet-Rich Plasma for the Treatment of Bladder Pain Syndrome: A Comprehensive Literature Review

Antibiotics ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 1194
Author(s):  
Francesco Trama ◽  
Ester Illiano ◽  
Alessandro Marchesi ◽  
Stefano Brancorsini ◽  
Felice Crocetto ◽  
...  
Keyword(s):  
Interstitial Cystitis ◽  
Chronic Inflammation ◽  
Platelet Rich Plasma ◽  
Pain Syndrome ◽  
Clinical History ◽  
Bladder Pain Syndrome ◽  
Therapeutic Effects ◽  
Bladder Pain ◽  
Painful Bladder ◽  
A Chain

Background: Bladder pain syndrome/interstitial cystitis (BPS/IC) or primary bladder pain syndrome (PBPS) is a complex and poorly understood condition. This comprehensive review aimed to discuss the potential application of platelet-rich plasma (PRP) in the treatment of BPS/IC. The pathophysiology of BPS/IC is characterized by urothelial damage that triggers a chain of events leading to chronic inflammation and other conditions. Frequently, in subjects affected by BPS/IC, recurrent urinary tract infection (rUTI) is associated with difficult therapeutic management. For these reasons, many oral and intravesical treatments (e.g., antibiotic therapy and intravesical anesthetic instillations) have been proposed to alleviate the symptoms of IC/BPS. However, the limitation of these treatments is the short duration of improvement. The purpose of this review is to analyze the efficacy of intravesical PRP injections in subjects with PBS/IC and to try to understand the potential therapeutic effects on the pathophysiology of this disease. Methods: A nonsystematic literature search using Pubmed, EMBASE, Scopus, Web of Science, Medline was performed from January 2000 to August 2021. The following terms were combined to capture relevant publications: “platelet-rich plasma”, “interstitial cystitis”, “PRP”, “bladder pain syndrome”, and “painful bladder syndrome”. Results: After exclusion of non-pertinent studies/articles, we have analyzed 5 studies. In detail, 2 articles concerned preclinical studies in which animal models were used. The authors showed an improvement in the histological pattern with less bleeding in treated subjects, a lower presence of inflammatory cytokines and an increase in the mitotic index of urothelial cells in animals treated with intravesical PRP. In the three prospective clinical trials analyzed, patients with BPS/IC who underwent monthly intravesical PRP injections were found to have a statistically significant improvement in symptoms with modulation of growth factors and inflammatory proteins. Conclusions: New evidence suggests that treatment with intravesical PRP could improve urothelial regeneration and reduces chronic inflammation in BPS/IC, modifying the clinical history of its pathology.

130: A Case-Control Study of Medical Co-Morbidities in Women with Interstitial Cystitis

2007 ◽  
Vol 177 (4S) ◽  
pp. 45-45
Author(s):  
J. Quentin Clemens ◽  
Richard T. Meenan ◽  
Maureen C. O’Keeffe Rosetti ◽  
Teresa M. Kimes ◽  
Elizabeth A. Calhoun
Keyword(s):  
Interstitial Cystitis ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

129: Sialic Acid Content of Urinary TAMM-Horsfall Protein is Reduced in Interstitial Cystitis Patients

2007 ◽  
Vol 177 (4S) ◽  
pp. 44-45
Author(s):  
C. Lowell Parsons ◽  
Mahadevan Rajasekaran ◽  
Marianne Chenoweth ◽  
Paul Stein
Keyword(s):  
Sialic Acid ◽  
Interstitial Cystitis ◽  
Acid Content ◽  
Sialic Acid Content

128: An Altered Differentiation Program in the Urothelium of Interstitial Cystitis Patients

2007 ◽  
Vol 177 (4S) ◽  
pp. 44-44
Author(s):  
Robert E. Hurst ◽  
Paul J. Hauser ◽  
Gennady A. Slobodov ◽  
Daniel J. Culkin
Keyword(s):  
Interstitial Cystitis
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