scholarly journals Oxygen gradient ektacytometry does not predict pain in children with sickle cell anaemia

2021 ◽  
Author(s):  
Amina Nardo‐Marino ◽  
Jesper Petersen ◽  
John N. Brewin ◽  
Henrik Birgens ◽  
Thomas N. Williams ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Oxygen Gradient

Hypofibronectinaemia and severity of sickle cell anaemia in Nigeria

2000 ◽  
Vol 111 (4) ◽  
pp. 1194-1197 ◽  
Author(s):  
A. O. Emeribe ◽  
A. E. Udoh ◽  
M. H. Etukudoh ◽  
C. C. Okany ◽  
M. Kehinde ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia

Blood plasma metabolomics of children and adolescents with sickle cell anaemia treated with hydroxycarbamide: a new tool for uncovering biochemical alterations

2021 ◽  
Vol 192 (5) ◽  
pp. 922-931
Author(s):  
Paulo R. Ribeiro ◽  
Rozana dos S. Teixeira ◽  
Alzenir R. Souza ◽  
Tayla C. S. Pereira ◽  
Elisangela F. Boffo ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Children And Adolescents ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Biochemical Alterations

scholarly journals Fetal‐haemoglobin enhancing genotype at BCL11A reduces HbA 2 levels in patients with sickle cell anaemia

eJHaem ◽  
2021 ◽  
Author(s):  
Titilope A. Adeyemo ◽  
Oyesola O. Ojewunmi ◽  
Idayat Ajoke Oyetunji ◽  
Olufunto Olufela Kalejaiye ◽  
Stephan Menzel
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Fetal Haemoglobin

scholarly journals Effects of Genotypes and Treatment on Oxygenscan Parameters in Sickle Cell Disease

Cells ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 811
Author(s):  
Camille Boisson ◽  
Minke A. E. Rab ◽  
Elie Nader ◽  
Céline Renoux ◽  
Celeste Kanne ◽  
...  
Keyword(s):  
Steady State ◽  
Sickle Cell Disease ◽  
Blood Cell ◽  
Sickle Cell ◽  
Red Blood Cell ◽  
Cell Disease ◽  
Oxygen Gradient ◽  
Acute Complication ◽  
Adults And Children ◽  
The Difference

(1) Background: The aim of the present study was to compare oxygen gradient ektacytometry parameters between sickle cell patients of different genotypes (SS, SC, and S/β+) or under different treatments (hydroxyurea or chronic red blood cell exchange). (2) Methods: Oxygen gradient ektacytometry was performed in 167 adults and children at steady state. In addition, five SS patients had oxygenscan measurements at steady state and during an acute complication requiring hospitalization. (3) Results: Red blood cell (RBC) deformability upon deoxygenation (EImin) and in normoxia (EImax) was increased, and the susceptibility of RBC to sickle upon deoxygenation was decreased in SC patients when compared to untreated SS patients older than 5 years old. SS patients under chronic red blood cell exchange had higher EImin and EImax and lower susceptibility of RBC to sickle upon deoxygenation compared to untreated SS patients, SS patients younger than 5 years old, and hydroxyurea-treated SS and SC patients. The susceptibility of RBC to sickle upon deoxygenation was increased in the five SS patients during acute complication compared to steady state, although the difference between steady state and acute complication was variable from one patient to another. (4) Conclusions: The present study demonstrates that oxygen gradient ektacytometry parameters are affected by sickle cell disease (SCD) genotype and treatment.

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