Blood plasma metabolomics of children and adolescents with sickle cell anaemia treated with hydroxycarbamide: a new tool for uncovering biochemical alterations

2021 ◽  
Vol 192 (5) ◽  
pp. 922-931
Author(s):  
Paulo R. Ribeiro ◽  
Rozana dos S. Teixeira ◽  
Alzenir R. Souza ◽  
Tayla C. S. Pereira ◽  
Elisangela F. Boffo ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Children And Adolescents ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Biochemical Alterations

scholarly journals Enuresis in children and adolescents with sickle cell anaemia is more frequent and substantially different from the general population

PLoS ONE ◽  
2018 ◽  
Vol 13 (8) ◽  
pp. e0201860 ◽  
Author(s):  
Christopher Imokhuede Esezobor ◽  
Patricia Akintan ◽  
Uche Nwaogazie ◽  
Edna Akinwunmi ◽  
Edamisan Temiye ◽  
...  
Keyword(s):  
General Population ◽  
Children And Adolescents ◽  
Sickle Cell ◽  
Sickle Cell Anaemia

scholarly journals Clinical depression in children and adolescents with sickle cell anaemia: influencing factors in a resource-limited setting

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Osita Ezenwosu ◽  
Barth Chukwu ◽  
Ifeyinwa Ezenwosu ◽  
Ndubuisi Uwaezuoke ◽  
Christopher Eke ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Disease Severity ◽  
Sickle Cell ◽  
Educational Level ◽  
Sickle Cell Anaemia ◽  
Sampling Technique ◽  
Resource Limited Setting ◽  
Cross Sectional ◽  
Resource Limited ◽  
Limited Setting

Abstract Background Sickle cell anaemia (SCA) is the commonest monogenic haematologic disorder resulting from the inheritance of homozygous mutant haemoglobin genes from both parents. Some factors have been identified as important in explaining the variability in depression in sickle cell anaemia (SCA). Information on this is limited in a resource-limited setting like Nigeria. This study aims to determine factors which influence depression in children and adolescents with sickle cell anaemia in a resource-limited setting. Methods Systematic random sampling technique was used in this cross-sectional study to select children and adolescents aged 7–17 years at the weekly sickle cell clinic of the University of Nigeria Teaching hospital (UNTH) Enugu, Nigeria. Pretested, structured questionnaire was used to collect sociodemographic and disease severity data while depression was assessed using the Children’s Depression Inventory. Results Age and educational level had significant positive linear relationships with depression (r = 0.253, p = 0.02; r = 0.225, p = 0.04 respectively) while gender (χ2 = 0.531, p = 0.466), socioeconomic status (χ2 = 0.451, p = 0.798) and disease severity (χ2 = 0.422, p = 0.810) had no relationship with depression in children and adolescents with SCA. Conclusion Depression in children and adolescents with SCA increased with increasing age and educational level. Psychological evaluation should be integrated into routine assessment of children with SCA during their follow up visits as they get older and progress in class.

scholarly journals Clinical Depression in Children and Adolescents With Sickle Cell Anaemia: Influencing Factors in a Resource-limited Setting

2021 ◽  
Author(s):  
Osita Uchenna Ezenwosu ◽  
Barth Friday Chukwu ◽  
Ifeyinwa Lilian Ezenwosu ◽  
Ndubuisi Anyaele Uwaezuoke ◽  
Christopher Bismarck Eke ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Disease Severity ◽  
Sickle Cell ◽  
Educational Level ◽  
Sickle Cell Anaemia ◽  
Sampling Technique ◽  
Resource Limited Setting ◽  
Cross Sectional ◽  
Resource Limited ◽  
Limited Setting

Abstract Background: Sickle cell anaemia (SCA) is the commonest monogenic haematologic disorder resulting from the inheritance of homozygous mutant haemoglobin genes from both parents. Some factors have been identified as important in explaining the variability in depression in sickle cell anaemia (SCA). Information on this is limited in a resource-limited setting like Nigeria. This study aims to determine factors which influence depression in children and adolescents with sickle cell anaemia in a resource-limited setting.Methods: Systematic random sampling technique was used in this cross-sectional study to select children and adolescents aged 7-17 years at the weekly sickle cell clinic of the University of Nigeria Teaching hospital (UNTH) Enugu, Nigeria. Pretested, structured questionnaire was used to collect sociodemographic and disease severity data while depression was assessed using the Children’s Depression Inventory.Results: Age and educational level had significant positive linear relationships with depression (r = 0.253, p = 0.02; r = 0.225, p = 0.04 respectively) while gender (χ2 = 0.531, p = 0.466), socioeconomic status (χ2 = 0.451, p = 0.798) and disease severity (χ2 = 0.422, p = 0.810) had no relationship with depression in children and adolescents with SCA.Conclusion: Depression in children and adolescents with SCA increased with increasing age and educational level. Psychological evaluation should be integrated into routine assessment of children with SCA during their follow up visits as they get older and progress in class.

Hypofibronectinaemia and severity of sickle cell anaemia in Nigeria

2000 ◽  
Vol 111 (4) ◽  
pp. 1194-1197 ◽  
Author(s):  
A. O. Emeribe ◽  
A. E. Udoh ◽  
M. H. Etukudoh ◽  
C. C. Okany ◽  
M. Kehinde ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia

Comprehensive Handbook of Childhood Cancer and Sickle Cell Disease

2006 ◽  
Keyword(s):  
Quality Of Life ◽  
Sickle Cell Disease ◽  
Childhood Cancer ◽  
Children And Adolescents ◽  
Peer Relationships ◽  
Sickle Cell ◽  
Cell Disease ◽  
Life Issues ◽  
Art Research

Over recent decades, tremendous advances in the prevention, medical treatment, and quality of life issues in children and adolescents surviving cancer have spawned a host of research on pediatric psychosocial oncology. This important volume fulfills the clear need for an up-to-date, comprehensive handbook for practitioners that delineates the most recent research in the field--the first of its kind in over a decade. Over 60 renowned authors have been assembled to provide a thorough presentation of the state-of-the art research and literature, with topics including: -Neuropsychological effects of chemotherapy and radiation therapy -Bone marrow transplantation -Important issues about quality of life during and following treatment -Collaborative research among child-focused psychologists -Standards of psychological care for children and adolescents -Stress and coping in the pediatric cancer experience -The role of family and peer relationships The Comprehensive Handbook of Childhood Cancer and Sickle Cell Disease represents both multidisciplinary and international efforts, an alliance between physicians and parents, and a combination of research and service. With a wealth of information of great interest to patients and their families, this volume will also be a welcome resource to the psychologists, psychiatrists, pediatricians, oncologists, nurses, and social workers who confront these issues as they help children and their families through the treatment, recovery, and grieving processes.

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