scholarly journals IgA kappa light and heavy chain deposition disease in multiple myeloma

2018 ◽  
Vol 183 (1) ◽  
pp. 13-13
Author(s):  
Aurélie Sannier ◽  
Guillaume Hanouna ◽  
Eric Daugas ◽  
Francois Vrtovsnik ◽  
Jean-Michel Goujon ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Heavy Chain ◽  
Deposition Disease ◽  
Heavy Chain Deposition Disease

Generalized Cutis Laxa Associated with Heavy Chain Deposition Disease

2003 ◽  
Vol 7 (5) ◽  
pp. 390-394 ◽  
Author(s):  
Stephen Tan ◽  
Kucy Pon ◽  
Joanne Bargman ◽  
Danny Ghazarian
Keyword(s):  
Multiple Myeloma ◽  
Heavy Chain ◽  
Cutis Laxa ◽  
Elastic Fibers ◽  
Elastic Tissue ◽  
Heavy Chains ◽  
Deposition Disease ◽  
Myélome Multiple ◽  
Light Chain Deposition ◽  
Heavy Chain Deposition Disease

Background: Cutis laxa is a heterogeneous group of inherited and acquired disorders characterized clinically by loose skin and histologically by altered elastic tissue. Heavy chain deposition disease is a very rare monoclonal immunoglobulin disorder, distinct from multiple myeloma, in which there is production and deposition of defective immunoglobulin heavy chains without light chain deposition. Objective: We describe a case of acquired cutis laxa associated with heavy chain deposition disease. Results: A 50-year-old male presented with acute renal failure, IgG4 heavy chain deposition in the kidneys, and no evidence of multiple myeloma. Four years later, he developed generalized acquired cutis laxa, emphysema, and a peripheral polyneuropathy. On pathology, there was destruction of elastic fibers within the dermis. Conclusion: This case describes a previously unreported association between acquired cutis laxa and heavy chain deposition disease. Antécédents: Cutis laxa est un groupe hétérogène de troubles héréditaires et acquis qui se caractérise cliniquement par un relâchement de la peau et histologiquement par l'altération du tissu élastique. La maladie des chaînes lourdes est un trouble très rare de l'immunoglobuline monoclonale, différent du myélome multiple où il y a production et dépôt de chaînes lourdes, sans chaînes légères, de l'immunoglobuline déficiente. Objectif: Description d'un cas non conventionnel de cutis laxa acquise associée à une maladie des chaînes légères. Méthodes: Description du cas et aperçu de cutis laxa. Observation: Un homme de 50 ans présente une insuffisance rénale, des dépêts dans les reins de chaînes lourdes IgG4 et aucune preuve de myélome multiple. Quatre ans plus tard, il développe une cutis laxa généralisée acquise, un emphysème et une Polyneuropathie périphérique. La pathologie a montré une destruction des fibres élastiques du derme. Conclusion: Ce cas décrit une association jamais établie auparavant entre cutis laxa et une maladie des chaînes lourdes.

Light-heavy chain deposition disease progressing to multiple myeloma

1995 ◽  
Vol 50 (4) ◽  
pp. 296-298 ◽  
Author(s):  
Danai Daliani ◽  
Donna Weber ◽  
Raymond Alexanian
Keyword(s):  
Multiple Myeloma ◽  
Heavy Chain ◽  
Deposition Disease ◽  
Heavy Chain Deposition Disease

scholarly journals Comprehensive molecular characterization of a heavy chain deposition disease case

Haematologica ◽  
2018 ◽  
Vol 103 (11) ◽  
pp. e557-e560 ◽  
Author(s):  
Sébastien Bender ◽  
Maria Victoria Ayala ◽  
Vincent Javaugue ◽  
Amélie Bonaud ◽  
Michel Cogné ◽  
...  
Keyword(s):  
Molecular Characterization ◽  
Heavy Chain ◽  
Deposition Disease ◽  
Disease Case ◽  
Heavy Chain Deposition Disease

scholarly journals Monoclonal gammopathy of renal significance with heavy‐chain deposition disease in renal allograft: challenges in the diagnosis and management

2019 ◽  
Vol 32 (7) ◽  
pp. 769-770
Author(s):  
Lavleen Singh ◽  
Arun Kumar Subbiah ◽  
Geetika Singh ◽  
Soumita Bagchi ◽  
Amit Kumar Dinda ◽  
...  
Keyword(s):  
Heavy Chain ◽  
Monoclonal Gammopathy ◽  
Renal Allograft ◽  
Diagnosis And Management ◽  
Deposition Disease ◽  
Heavy Chain Deposition Disease

scholarly journals AJKD Atlas of Renal Pathology: Heavy Chain Deposition Disease

2016 ◽  
Vol 67 (3) ◽  
pp. e11-e12 ◽  
Author(s):  
Agnes B. Fogo ◽  
Mark A. Lusco ◽  
Behzad Najafian ◽  
Charles E. Alpers
Keyword(s):  
Heavy Chain ◽  
Renal Pathology ◽  
Deposition Disease ◽  
Heavy Chain Deposition Disease

scholarly journals Gamma 1-heavy chain deposition disease accompanied by IgG kappa in serum, urine, and bone marrow

2013 ◽  
Vol 3 (1) ◽  
pp. 44-48 ◽  
Author(s):  
Keiichi Kaneko ◽  
Koichi Seta ◽  
Jun Soma ◽  
Takashi Kuwahara ◽  
Mitsuteru Koizumi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Heavy Chain ◽  
Deposition Disease ◽  
Heavy Chain Deposition Disease

scholarly journals Recurrent light and heavy chain deposition disease after renal transplantation

2005 ◽  
Vol 20 (7) ◽  
pp. 1487-1491 ◽  
Author(s):  
Bassam Alchi ◽  
Shinichi Nishi ◽  
Seitaro Iguchi ◽  
Masaaki Shimotori ◽  
Minoru Sakatsume ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Heavy Chain ◽  
Deposition Disease ◽  
Heavy Chain Deposition Disease
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