scholarly journals Association between oxidative stress and vascular reactivity in children with sickle cell anaemia and sickle haemoglobin C disease

2017 ◽  
Vol 178 (3) ◽  
pp. 468-475 ◽  
Author(s):  
Berenike Möckesch ◽  
Philippe Connes ◽  
Keyne Charlot ◽  
Sarah Skinner ◽  
Marie-Dominique Hardy-Dessources ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sickle Cell ◽  
Vascular Reactivity ◽  
Sickle Cell Anaemia ◽  
Haemoglobin C

scholarly journals The Effect of a Selective Inhibitor of Phosphodiesterase-9 on Oxidative Stress, Inflammation and Cytotoxicity in Neutrophils from Patients with Sickle Cell Anaemia

2015 ◽  
Vol 118 (4) ◽  
pp. 271-278 ◽  
Author(s):  
Maritza Cavalcante Barbosa ◽  
Talyta Ellen de Jesus dos Santos ◽  
Thayna Nogueira dos Santos ◽  
Alano Martins Pedrosa ◽  
Darcielle Bruna Dias Elias ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Selective Inhibitor

scholarly journals Arginine therapy of transgenic-knockout sickle mice improves microvascular function by reducing non-nitric oxide vasodilators, hemolysis, and oxidative stress

2008 ◽  
Vol 295 (1) ◽  
pp. H39-H47 ◽  
Author(s):  
Dhananjay K. Kaul ◽  
Xiaoqin Zhang ◽  
Trisha Dasgupta ◽  
Mary E. Fabry
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Vascular Reactivity ◽  
Microvascular Function ◽  
Cell Disease ◽  
No Bioavailability ◽  
Cox 2 ◽  
And Oxidative Stress

In sickle cell disease, nitric oxide (NO) depletion by cell-free plasma hemoglobin and/or oxygen radicals is associated with arginine deficiency, impaired NO bioavailability, and chronic oxidative stress. In transgenic-knockout sickle (BERK) mice that express exclusively human α- and βS-globins, reduced NO bioavailability is associated with induction of non-NO vasodilator enzyme, cyclooxygenase (COX)-2, and impaired NO-mediated vascular reactivity. We hypothesized that enhanced NO bioavailability in sickle mice will abate activity of non-NO vasodilators, improve vascular reactivity, decrease hemolysis, and reduce oxidative stress. Arginine treatment of BERK mice (5% arginine in mouse chow for 15 days) significantly reduced expression of non-NO vasodilators COX-2 and heme oxygenase-1. The decreased COX-2 expression resulted in reduced prostaglandin E2(PGE2) levels. The reduced expression of non-NO vasodilators was associated with significantly decreased arteriolar dilation and markedly improved NO-mediated vascular reactivity. Arginine markedly decreased hemolysis and oxidative stress and enhanced NO bioavailability. Importantly, arteriolar diameter response to a NO donor (sodium nitroprusside) was strongly correlated with hemolytic rate (and nitrotyrosine formation), suggesting that the improved microvascular function was a response to reduced hemolysis. These results provide a strong rationale for therapeutic use of arginine in sickle cell disease and other hemolytic diseases.

scholarly journals Effect of Age on Blood Rheology in Sickle Cell Anaemia and Sickle Cell Haemoglobin C Disease: A Cross-Sectional Study

PLoS ONE ◽  
2016 ◽  
Vol 11 (6) ◽  
pp. e0158182 ◽  
Author(s):  
Céline Renoux ◽  
Marc Romana ◽  
Philippe Joly ◽  
Séverine Ferdinand ◽  
Camille Faes ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Blood Rheology ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Effect Of Age ◽  
Haemoglobin C

scholarly journals Relationship of oxidative stress and antioxidant response with vaso-occlusive crisis in sickle cell anaemia

2021 ◽  
Vol 21 (1) ◽  
pp. 150-8
Author(s):  
Godwill Azeh Engwa ◽  
Amanda Okolie ◽  
John Paul Chinedu Chidili ◽  
Precious Amara Okore ◽  
Paul Chigozie Onu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Antioxidant Response ◽  
Cross Sectional ◽  
Baseline Information ◽  
Nigeria Teaching Hospital ◽  
Relationship Of ◽  
Cell Carriers ◽  
The Relationship

Background: Though sickle cell anaemia (SCA) is known to promote oxidative stress, there is paucity of information on the relationship between oxidative stress and vaso-occlusive crisis (VOC). Objective: This study was undertaken to evaluate the relationship of oxidative stress and antioxidant response with VOC in SCA. Methods: A cross-sectional case-control study was carried out at University of Nigeria Teaching Hospital (UNTH), Itu- ku-Ozalla, Enugu Nigeria involving 116 individuals which included 36 SCA subject, 40 sickle cell carriers (AS) and 40 healthy individuals (AA). Baseline information as well as the frequency of VOC was obtained from the participants and anaemia as well as oxidative stress and antioxidant indices were assessed in blood. Results: Anaemia was prevalent (88.9 %) in SCA individuals compared to AS (52.5%) and AA (47.5 %) individuals. Nitric oxide scavenging (NOS) and superoxide dismutase (SOD) activities as well as glutathione level were significantly (p<0.005) lower while catalase activity was higher in SCA individuals compared to controls (AA and AS). Higher malondialdehyde (MDA) level was associated with very severe VOC while low level of NOS activity was associated with severe VOC in SCA individuals. Conclusion: Sickle cell anaemia exhibited oxidative stress and alteration in the levels of antioxidant indices which was pos- sibly associated with vaso-occlusive crisis. Keywords: Sickle cell anaemia; oxidative stress; antioxidant; vaso-occlusive crisis.

scholarly journals Oxidative stress markers and disease severity among children with Sickle Cell Anaemia

2019 ◽  
pp. 193-202
Author(s):  
OS Smith ◽  
SA Adegoke ◽  
MA Akinlosotu ◽  
OA Ajose
Keyword(s):  
Oxidative Stress ◽  
Disease Severity ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Stress Index ◽  
Oxidative Stress Markers ◽  
Mild Disease ◽  
Stress Markers ◽  
Moderate Disease ◽  
The Mean

Background: Sickle cell anaemia has been associated with oxidative stress. Total Antioxidant Capacity (TAC), Total Oxidant Status (TOS) and Oxidative Stress Index (OSI) are cumulative markers of oxidative stress. Objective: To evaluate the serum levels of oxidative stress markers in children with sickle cell anaemia (SCA) and determine the relationship between these markers and disease severity. Method: One hundred and fifty-six children, comprising 78 with SCA, aged 1 - 15 years and 78 age- and sex-matched Haemoglobin AA controls were studied. Serum TOS, OSI, and TAC were determined using ELISA kits. The severity of the SCA was determined using clinical and laboratory parameters. Result: Children with SCA had lower mean serum TAC (0.83±0.31UAE) than controls (1.19±0.24UAE) with p<0.001. However, the mean serum TOS and OSI of children with SCA was higher than among the controls (13.33±4.64U/ml vs. 9.70±2.72U/ml and 20.95±16.75 vs. 8.68±3.76 respectively) with p<0.001. SCA subjects with mild disease had higher mean serum TAC (0.91 ± 0.27UAE) than those with moderate disease (0.54±0.27UAE) (p<0.001). On the other hand, the mean TOS and OSI were lower in children with mild disease compared to those with moderate disease (12.64±4.32U/ml vs. 15.63±5.07U/ml, p = 0.016 and 16.26±10.25 vs. 36.61±23.89 p<0.001 respectively). Sickle cell disease severity score had negative correlation with TAC (r = -0.60, p < 0.001) but positive correlation with TOS (r = 0.3, p = 0.008) and OSI (r = 0.6, p < 0.001). Conclusion: Children with SCA had lower TAC but higher TOS and OSI than matched controls. Oxidative stress markers had a significant relationship with SCD severity.

scholarly journals Moderate endurance exercise in patients with sickle cell anaemia: effects on oxidative stress and endothelial activation

2013 ◽  
Vol 164 (1) ◽  
pp. 124-130 ◽  
Author(s):  
Camille Faes ◽  
Edwige Balayssac-Siransy ◽  
Philippe Connes ◽  
Ludovic Hivert ◽  
Clotaire Danho ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sickle Cell ◽  
Endurance Exercise ◽  
Sickle Cell Anaemia ◽  
Endothelial Activation
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