scholarly journals Moderate endurance exercise in patients with sickle cell anaemia: effects on oxidative stress and endothelial activation

2013 ◽  
Vol 164 (1) ◽  
pp. 124-130 ◽  
Author(s):  
Camille Faes ◽  
Edwige Balayssac-Siransy ◽  
Philippe Connes ◽  
Ludovic Hivert ◽  
Clotaire Danho ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sickle Cell ◽  
Endurance Exercise ◽  
Sickle Cell Anaemia ◽  
Endothelial Activation

scholarly journals The Effect of a Selective Inhibitor of Phosphodiesterase-9 on Oxidative Stress, Inflammation and Cytotoxicity in Neutrophils from Patients with Sickle Cell Anaemia

2015 ◽  
Vol 118 (4) ◽  
pp. 271-278 ◽  
Author(s):  
Maritza Cavalcante Barbosa ◽  
Talyta Ellen de Jesus dos Santos ◽  
Thayna Nogueira dos Santos ◽  
Alano Martins Pedrosa ◽  
Darcielle Bruna Dias Elias ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Selective Inhibitor

scholarly journals Relationship of oxidative stress and antioxidant response with vaso-occlusive crisis in sickle cell anaemia

2021 ◽  
Vol 21 (1) ◽  
pp. 150-8
Author(s):  
Godwill Azeh Engwa ◽  
Amanda Okolie ◽  
John Paul Chinedu Chidili ◽  
Precious Amara Okore ◽  
Paul Chigozie Onu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Antioxidant Response ◽  
Cross Sectional ◽  
Baseline Information ◽  
Nigeria Teaching Hospital ◽  
Relationship Of ◽  
Cell Carriers ◽  
The Relationship

Background: Though sickle cell anaemia (SCA) is known to promote oxidative stress, there is paucity of information on the relationship between oxidative stress and vaso-occlusive crisis (VOC). Objective: This study was undertaken to evaluate the relationship of oxidative stress and antioxidant response with VOC in SCA. Methods: A cross-sectional case-control study was carried out at University of Nigeria Teaching Hospital (UNTH), Itu- ku-Ozalla, Enugu Nigeria involving 116 individuals which included 36 SCA subject, 40 sickle cell carriers (AS) and 40 healthy individuals (AA). Baseline information as well as the frequency of VOC was obtained from the participants and anaemia as well as oxidative stress and antioxidant indices were assessed in blood. Results: Anaemia was prevalent (88.9 %) in SCA individuals compared to AS (52.5%) and AA (47.5 %) individuals. Nitric oxide scavenging (NOS) and superoxide dismutase (SOD) activities as well as glutathione level were significantly (p<0.005) lower while catalase activity was higher in SCA individuals compared to controls (AA and AS). Higher malondialdehyde (MDA) level was associated with very severe VOC while low level of NOS activity was associated with severe VOC in SCA individuals. Conclusion: Sickle cell anaemia exhibited oxidative stress and alteration in the levels of antioxidant indices which was pos- sibly associated with vaso-occlusive crisis. Keywords: Sickle cell anaemia; oxidative stress; antioxidant; vaso-occlusive crisis.

scholarly journals Mild haemorheological changes induced by a moderate endurance exercise in patients with sickle cell anaemia

2011 ◽  
Vol 154 (3) ◽  
pp. 398-407 ◽  
Author(s):  
Edwige Balayssac-Siransy ◽  
Philippe Connes ◽  
Nalourgo Tuo ◽  
Clotaire Danho ◽  
Mor Diaw ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Endurance Exercise ◽  
Sickle Cell Anaemia

scholarly journals Oxidative stress markers and disease severity among children with Sickle Cell Anaemia

2019 ◽  
pp. 193-202
Author(s):  
OS Smith ◽  
SA Adegoke ◽  
MA Akinlosotu ◽  
OA Ajose
Keyword(s):  
Oxidative Stress ◽  
Disease Severity ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Stress Index ◽  
Oxidative Stress Markers ◽  
Mild Disease ◽  
Stress Markers ◽  
Moderate Disease ◽  
The Mean

Background: Sickle cell anaemia has been associated with oxidative stress. Total Antioxidant Capacity (TAC), Total Oxidant Status (TOS) and Oxidative Stress Index (OSI) are cumulative markers of oxidative stress. Objective: To evaluate the serum levels of oxidative stress markers in children with sickle cell anaemia (SCA) and determine the relationship between these markers and disease severity. Method: One hundred and fifty-six children, comprising 78 with SCA, aged 1 - 15 years and 78 age- and sex-matched Haemoglobin AA controls were studied. Serum TOS, OSI, and TAC were determined using ELISA kits. The severity of the SCA was determined using clinical and laboratory parameters. Result: Children with SCA had lower mean serum TAC (0.83±0.31UAE) than controls (1.19±0.24UAE) with p<0.001. However, the mean serum TOS and OSI of children with SCA was higher than among the controls (13.33±4.64U/ml vs. 9.70±2.72U/ml and 20.95±16.75 vs. 8.68±3.76 respectively) with p<0.001. SCA subjects with mild disease had higher mean serum TAC (0.91 ± 0.27UAE) than those with moderate disease (0.54±0.27UAE) (p<0.001). On the other hand, the mean TOS and OSI were lower in children with mild disease compared to those with moderate disease (12.64±4.32U/ml vs. 15.63±5.07U/ml, p = 0.016 and 16.26±10.25 vs. 36.61±23.89 p<0.001 respectively). Sickle cell disease severity score had negative correlation with TAC (r = -0.60, p < 0.001) but positive correlation with TOS (r = 0.3, p = 0.008) and OSI (r = 0.6, p < 0.001). Conclusion: Children with SCA had lower TAC but higher TOS and OSI than matched controls. Oxidative stress markers had a significant relationship with SCD severity.

scholarly journals Oxidative stress and phosphatidylserine exposure in red cells from patients with sickle cell anaemia

2018 ◽  
Vol 182 (4) ◽  
pp. 567-578 ◽  
Author(s):  
Anke Hannemann ◽  
David C. Rees ◽  
John N. Brewin ◽  
Andreas Noe ◽  
Ben Low ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Red Cells ◽  
Phosphatidylserine Exposure

scholarly journals Association between oxidative stress and vascular reactivity in children with sickle cell anaemia and sickle haemoglobin C disease

2017 ◽  
Vol 178 (3) ◽  
pp. 468-475 ◽  
Author(s):  
Berenike Möckesch ◽  
Philippe Connes ◽  
Keyne Charlot ◽  
Sarah Skinner ◽  
Marie-Dominique Hardy-Dessources ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sickle Cell ◽  
Vascular Reactivity ◽  
Sickle Cell Anaemia ◽  
Haemoglobin C

scholarly journals Glutathione and Bilirubin Concentrations as Markers of Oxidative Stress Measured among Sickle Cell Anaemia Subjects Attending University of Calabar Teaching Hospital, Calabar Nigeria

2019 ◽  
pp. 1-6
Author(s):  
E. E. Onukak ◽  
E. C. Akwiwu ◽  
J. O. Akpotuzor ◽  
A. O. Okafor ◽  
A. E. Onukak
Keyword(s):  
Oxidative Stress ◽  
Sickle Cell ◽  
Teaching Hospital ◽  
Sickle Cell Anaemia ◽  
Glutathione Depletion ◽  
Enzyme Linked Immunosorbent Assay ◽  
Red Cell ◽  
Distribution Width ◽  
Cell Parameters ◽  
Control Subjects

Aims: This study aimed at examining the oxidative stress level of sickle cell anaemia subjects using glutathione and bilirubin levels as markers as well as the red cell parameters. Study Design: Case-control study. Place and Duration of Study: University of Calabar Teaching Hospital, Calabar-Nigeria, between August 2018 and July 2019. Methodology: Subjects comprised 45 SCA patients (27 females, 18 males; age range 10-45 years) attending clinic at University of Calabar Teaching Hospital Calabar, Nigeria and equal number of age and sex-matched control subjects with Hb AA. Blood samples were collected and analyzed by standard methods. The red cell parameters were analysed by automation using FY-Smart-1 auto haematology analyzer. Bilirubin assay was performed using the colorimetric method, while glutathione was performed by enzyme-linked immunosorbent assay technique. Results: The red blood cell count, haemoglobin concentration, and haematocrit values of SCA subjects were significantly lower (p=0.001) compared to values from control subjects, while the red cell indices and red cell distribution width values were increased in SCA subjects (p=0.001). The Total bilirubin, conjugated bilirubin and unconjugated bilirubin were significantly increased (p=0.001) among SCA subjects, while the glutathione concentration values were reduced (p=0.001) when compared to values obtained from control subjects. Conclusion: SCA subjects have marked red cell size variation, lymphocytosis and thrombocytosis. The haemolytic events that occur in sickle cell anaemia results in glutathione depletion.

Oxidative stress and antioxidant capacity in sickle cell anaemia patients receiving different treatments and medications for different periods of time

2011 ◽  
Vol 91 (4) ◽  
pp. 479-489 ◽  
Author(s):  
Edis Belini Junior ◽  
Danilo Grünig Humberto da Silva ◽  
Lidiane de Souza Torres ◽  
Eduardo Alves de Almeida ◽  
Rodolfo Delfini Cancado ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Capacity ◽  
Sickle Cell ◽  
Sickle Cell Anaemia

Hypofibronectinaemia and severity of sickle cell anaemia in Nigeria

2000 ◽  
Vol 111 (4) ◽  
pp. 1194-1197 ◽  
Author(s):  
A. O. Emeribe ◽  
A. E. Udoh ◽  
M. H. Etukudoh ◽  
C. C. Okany ◽  
M. Kehinde ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia
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