scholarly journals Lymphoedema in patients with lentigo maligna treated with imiquimod: a long-term adverse effect

2018 ◽  
Vol 178 (6) ◽  
pp. 1441-1442 ◽  
Author(s):  
D. Tio ◽  
G. Kirtschig ◽  
R. Hoekzema ◽  
C. van Montfrans
Keyword(s):  
Adverse Effect ◽  
Lentigo Maligna ◽  
Term Adverse Effect

The Disability Discrimination Act 1995: implications for psychiatrists

2003 ◽  
Vol 9 (6) ◽  
pp. 397-404 ◽  
Author(s):  
Liz Sayce ◽  
Jed Boardman
Keyword(s):  
Mental Health ◽  
Adverse Effect ◽  
Educational Opportunities ◽  
Service Users ◽  
Disability Discrimination ◽  
Term Adverse Effect ◽  
Discrimination In Employment ◽  
Disability Discrimination Act ◽  
Employment Rights

The Disability Discrimination Act, passed by Parliament in 1995, is an important piece of legislation with the potential to protect the employment rights of people with disabilities. It covers people with physical or mental impairments that have a substantial and long-term adverse effect on their ability to carry out normal day-to-day activities. The Act has sections regarding protection from discrimination in employment, in the provision of goods, services and facilities, and in education. These parts of the Act have implications for people working in mental health services when they are considering employment and educational opportunities for service users.

scholarly journals Selenium in the Prevention of Anthracycline-Induced Cardiac Toxicity in Children with Cancer

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Nurdan Tacyildiz ◽  
Derya Ozyoruk ◽  
Guzin Ozelci Kavas ◽  
Gulsan Yavuz ◽  
Emel Unal ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Plasma Level ◽  
Protective Effect ◽  
Pediatric Cancer ◽  
Cardiac Toxicity ◽  
Chemotherapeutic Agents ◽  
Children With Cancer ◽  
Term Adverse Effect ◽  
Pediatric Cancer Patients

High cumulative doses of anthracyclines (300–500 mg/m2) used in the treatment of children with cancer may result in cardiotoxicity, a major long-term adverse effect that limits clinical usefulness of this class of chemotherapeutic agents. We assessed anthracycline-induced cardiotoxicity by measuring Pro-BNP levels and echocardiographic (ECHO) findings and investigated potential protective effect of selenium (Se) supplementation in a group of pediatric cancer patients. Plasma level of Pro-BNP was measured, and ECHO was performed in 67 patients (45 boys, 22 girls; ages 2–18 years; median age 12 years) after they completed anthracycline-containing chemotherapy. Serum Se level was measured in 37 patients. Eleven patients had high Pro-BNP levels and/or cardiac failure with Pro-BNP levels of 10–8,022 pg/mL (median 226.3 pg/mL; laboratory normal level is less than 120 pg/mL). Serum Se levels were low (20–129 mcg/L, median 62 mcg/L) in ten of these eleven patients. Eight of 10 patients with low Se and high Pro-BNP levels were supplemented with Se 100 mcg/day for a period of 4–33 months (median 6 months) which resulted in improvement in Pro-BNP and/or ECHO findings. These results suggest that Se supplementation may have a role in protection against anthracycline-induced cardiac toxicity.

scholarly journals Severe acitretin-induced diffuse idiopathic skeletal hyperostosis: a case report

2020 ◽  
Vol 48 (10) ◽  
pp. 030006052096689 ◽  
Author(s):  
Gabrielle Gour-Provençal ◽  
Nicholas M. Newman ◽  
Mathieu Boudier-Revéret ◽  
Min Cheol Chang
Keyword(s):  
Adverse Effect ◽  
Emergency Department ◽  
Hip Replacement ◽  
Daily Living ◽  
Diffuse Idiopathic Skeletal Hyperostosis ◽  
Limited Range ◽  
Anterior Longitudinal Ligament ◽  
Limited Range Of Motion ◽  
Term Adverse Effect

Diffuse idiopathic skeletal hyperostosis (DISH), also known as Forestier–Rotes–Querol disease, is a systemic noninflammatory disease characterized by ossification of the entheses. DISH predominantly affects the spine. Although peripheral involvement is also often reported, it rarely affects patients’ function. A 77-year-old man presented to our emergency department because of incapacitating pain and stiffness in the spine and hips. The patient had been diagnosed with biopsy-proven mycosis fungoides 3 years earlier and had been treated with oral acitretin at 25 to 50 mg daily since diagnosis. However, the patient gradually developed a severely limited range of motion in his spine and hips (left > right), significantly impairing his mobility and activities of daily living. Cervical and dorsolumbar radiographs showed extensive ossification along the anterior longitudinal ligament; this finding was compatible with DISH and had not been present in radiographs taken 3 years earlier. Pelvic radiographs showed multiple enthesophytes predominantly around the coxofemoral joints. DISH has been reported as a possible long-term adverse effect of acitretin. Despite optimal conservative treatment, the patient remained severely impaired and thus finally underwent extensive osteophyte excision and total hip replacement on the left side. His acitretin therapy was also stopped to prevent further progression of his DISH.

scholarly journals Prolonged Local Hypothermia Has No Long-Term Adverse Effect on the Spinal Cord

2015 ◽  
Vol 5 (3) ◽  
pp. 152-162 ◽  
Author(s):  
Ashwati Vipin ◽  
Jukka Kortelainen ◽  
Hasan Al-Nashash ◽  
Soo Min Chua ◽  
Xinyuan Thow ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Spinal Cord ◽  
Term Adverse Effect ◽  
Local Hypothermia

scholarly journals Chronic Administration of 7,8-DHF Lessens the Depression-Like Behavior of Juvenile Mild Traumatic Brain Injury Treated Rats at Their Adult Age

Pharmaceutics ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 2169
Author(s):  
Shih-Te Yang ◽  
Hsiu-Yi Hung ◽  
Long-Sun Ro ◽  
Ming-Feng Liao ◽  
Tamara G. Amstislavskaya ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Brain Edema ◽  
Dorsal Hippocampus ◽  
Chronic Administration ◽  
Motor Deficits ◽  
Adult Age ◽  
Term Adverse Effect

Traumatic brain injury (TBI) is a leading cause of mortality and morbidity among the global youth and commonly results in long-lasting sequelae, including paralysis, epilepsy, and a host of mental disorders such as major depressive disorder. Previous studies were mainly focused on severe TBI as it occurs in adults. This study explored the long-term adverse effect of mild TBI in juvenile animals (mTBI-J). Male Sprague Dawley rats received mTBI-J or sham treatment at six weeks old, then underwent behavioral, biochemical, and histological experiments three weeks later (at nine weeks old). TTC staining, H&E staining, and brain edema measurement were applied to evaluate the mTBI-J induced cerebral damage. The forced swimming test (FST) and sucrose preference test (SPT) were applied for measuring depression-like behavior. The locomotor activity test (LAT) was performed to examine mTBI-J treatment effects on motor function. After the behavioral experiments, the dorsal hippocampus (dHip) and ventral hippocampus (vHip) were dissected out for western blotting to examine the expression of brain-derived neurotrophic factor (BDNF) and tropomyosin receptor kinase B (TrkB). Finally, a TrkB agonist 7,8-DHF was injected intraperitoneally to evaluate its therapeutic effect on the mTBI-J induced behavioral abnormalities at the early adult age. Results showed that a mild brain edema occurred, but no significant neural damage was found in the mTBI-J treated animals. In addition, a significant increase of depression-like behaviors was observed in the mTBI-J treated animals; the FST revealed an increase in immobility, and a decrease in sucrose consumption was found in the mTBI-J treated animals. There were no differences observed in the total distance traveled of the LAT and the fall latency of the rotarod test. The hippocampal BDNF expression, but not the TrkB, were significantly reduced in mTBI-J, and the mTBI-J treatment-induced depression-like behavior was lessened after four weeks of 7,8-DHF administration. Collectively, these results indicate that even a mild juvenile TBI treatment that did not produce motor deficits or significant histological damage could have a long-term adverse effect that could be sustained to adulthood, which raises the depression-like behavior in the adult age. In addition, chronic administration of 7,8-DHF lessens the mTBI-J treatment-induced depression-like behaviors in adult rats. We suggest the potential usage of 7,8-DHF as a therapeutic agent for preventing the long-term adverse effect of mTBI-J.

PSYCHOLOGICAL IMPACT OF CARDIAC CATHETERIZATION

PEDIATRICS ◽  
1973 ◽  
Vol 51 (6) ◽  
pp. 1051-1059
Author(s):  
Ruth B. Aisenberg ◽  
Peter H. Wolff ◽  
Amnon Rosenthal ◽  
Alexander S. Nadas
Keyword(s):  
Adverse Effect ◽  
Cardiac Catheterization ◽  
Play Therapy ◽  
Psychological Impact ◽  
Age Groups ◽  
Verbal Aggression ◽  
Behavior Patterns ◽  
Somatic Anxiety ◽  
Term Adverse Effect

Fifty children between 4 and 15 years of age were subdivided into three age groups and studied before, during, and after cardiac catheterization. Nearly all of the youngest, but less than half of the oldest patients manifested negative behavioral and intrapsychic changes after catheterization. The behavior patterns of the youngest children were affected specifically in the domains of regression, aggression, affectivity, and attitude. The increase of general and somatic anxiety was equally distributed among older and younger children. Among boys the increase of aggression was typically expressed in physical modes, whereas girls more often responded by verbal aggression. Since children do not perceive cardiac catheterization as an innocuous procedure, and the catheterization experience may, in selected cases, interact with previously existing conditions to produce long-term adverse effect, intervention to protect very young cardiac patients may be advisable. Prophylactic play therapy could be utilized; or where medically feasible, cardiac catheterization could be postponed until later childhood.

The long-term use of sedative hypnotics in chronic insomnia

2014 ◽  
Vol 4 (2) ◽  
pp. 78-81
Author(s):  
Chelsie B. Heesch
Keyword(s):  
Adverse Effect ◽  
Adverse Effects ◽  
Chronic Condition ◽  
Current Practice ◽  
Adverse Effect Profile ◽  
Short Term ◽  
Safety And Efficacy ◽  
Term Adverse Effect ◽  
Sedative Hypnotics

Symptoms of insomnia are highly prevalent among adults and insomnia is often a chronic condition which may occur for years. Sedative hypnotics including benzodiazepines (BZDs), zolpidem, eszopiclone, and zaleplon (NBZDs) are commonly used to treat insomnia. The longest controlled studies evaluating the safety and efficacy of NBZDs were 12 months in duration and 2 months in duration for the BZD, temazepam. These studies suggest that NBZDs continue to be effective and safe when used for up to 12 months. The short-term adverse effects are more common and more severe for BZDs than for NBZDs. Despite the current practice of using sedative hypnotics for longer durations, studies have yet to evaluate the long-term adverse effect profile.

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