Baicalein attenuates hypertrophic scar formation via inhibition of the transforming growth factor‐β/Smad2/3 signalling pathway

2015 ◽  
Vol 174 (1) ◽  
pp. 120-130 ◽  
Author(s):  
Y.F. Zhang ◽  
S.Z. Zhou ◽  
X.Y. Cheng ◽  
B. Yi ◽  
S.Z. Shan ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hypertrophic Scar ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Scar Formation ◽  
Signalling Pathway

scholarly journals Evidence that gastropod torsion is driven by asymmetric cell proliferation activated by TGF-β signalling

2011 ◽  
Vol 7 (5) ◽  
pp. 759-762 ◽  
Author(s):  
Yoshihisa Kurita ◽  
Hiroshi Wada
Keyword(s):  
Cell Proliferation ◽  
Growth Factor ◽  
Driving Force ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Signalling Pathway ◽  
Retractor Muscle ◽  
Cast Doubt ◽  
The Right ◽  
Ontogenetic Process

Gastropods are characterized by their asymmetric bodyplan, which develops through a unique ontogenetic process called ‘torsion’. Despite several intensive studies, the driving force of torsion remains to be determined. Although torsion was traditionally believed to be driven by contraction of the retractor muscle connecting the foot and the shell, some recent reports cast doubt on that idea. Here, we report that torsion is accompanied by left–right asymmetric cell proliferation in the mantle epithelium in the limpet Nipponacmea fuscoviridis . Furthermore, we found that pharmacological inhibition of the transforming growth factor-β (TGF-β) signalling pathway, including that of Nodal, blocked torsion. We confirmed that the blocking was brought about through failure of the activation of cell proliferation in the right-hand side of the mantle epithelium, while the retractor muscle apparently developed normally. These results suggest that limpet torsion is driven by left–right asymmetric cell proliferation in the mantle epithelium, induced by the TGF-β pathway.

Modulation of Collagen Synthesis by Transforming Growth Factor-β in Keloid and Hypertrophic Scar Fibroblasts

1994 ◽  
Vol 33 (2) ◽  
pp. 148-154 ◽  
Author(s):  
Soheil Younai ◽  
Larry S. Nichter ◽  
Tadeusz Wellisz ◽  
John Reinisch ◽  
Marcel E. Nimni ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hypertrophic Scar ◽  
Collagen Synthesis ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β

scholarly journals Inhibition of CD1d-mediated antigen presentation by the transforming growth factor-β/Smad signalling pathway

Immunology ◽  
2014 ◽  
Vol 143 (4) ◽  
pp. 679-691 ◽  
Author(s):  
Jennifer C. Bailey ◽  
Abhirami K. Iyer ◽  
Gourapura J. Renukaradhya ◽  
Yinling Lin ◽  
Hoa Nguyen ◽  
...  
Keyword(s):  
Growth Factor ◽  
Antigen Presentation ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Signalling Pathway

scholarly journals Expression and clinical significance of the transforming growth factor-β signalling pathway in endometrial cancer

2011 ◽  
Vol 59 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Paulette Mhawech-Fauceglia ◽  
Joshua Kesterson ◽  
Dan Wang ◽  
Stacey Akers ◽  
Nefertiti Chianti DuPont ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Growth Factor ◽  
Clinical Significance ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Signalling Pathway
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