Targeting the transforming growth factor-β signalling pathway in metastatic cancer

2010 ◽  
Vol 46 (7) ◽  
pp. 1232-1240 ◽  
Author(s):  
Manav Korpal ◽  
Yibin Kang
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Metastatic Cancer ◽  
Transforming Growth Factor Β ◽  
Signalling Pathway

scholarly journals Evidence that gastropod torsion is driven by asymmetric cell proliferation activated by TGF-β signalling

2011 ◽  
Vol 7 (5) ◽  
pp. 759-762 ◽  
Author(s):  
Yoshihisa Kurita ◽  
Hiroshi Wada
Keyword(s):  
Cell Proliferation ◽  
Growth Factor ◽  
Driving Force ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Signalling Pathway ◽  
Retractor Muscle ◽  
Cast Doubt ◽  
The Right ◽  
Ontogenetic Process

Gastropods are characterized by their asymmetric bodyplan, which develops through a unique ontogenetic process called ‘torsion’. Despite several intensive studies, the driving force of torsion remains to be determined. Although torsion was traditionally believed to be driven by contraction of the retractor muscle connecting the foot and the shell, some recent reports cast doubt on that idea. Here, we report that torsion is accompanied by left–right asymmetric cell proliferation in the mantle epithelium in the limpet Nipponacmea fuscoviridis . Furthermore, we found that pharmacological inhibition of the transforming growth factor-β (TGF-β) signalling pathway, including that of Nodal, blocked torsion. We confirmed that the blocking was brought about through failure of the activation of cell proliferation in the right-hand side of the mantle epithelium, while the retractor muscle apparently developed normally. These results suggest that limpet torsion is driven by left–right asymmetric cell proliferation in the mantle epithelium, induced by the TGF-β pathway.

scholarly journals Inhibition of CD1d-mediated antigen presentation by the transforming growth factor-β/Smad signalling pathway

Immunology ◽  
2014 ◽  
Vol 143 (4) ◽  
pp. 679-691 ◽  
Author(s):  
Jennifer C. Bailey ◽  
Abhirami K. Iyer ◽  
Gourapura J. Renukaradhya ◽  
Yinling Lin ◽  
Hoa Nguyen ◽  
...  
Keyword(s):  
Growth Factor ◽  
Antigen Presentation ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Signalling Pathway

scholarly journals Expression and clinical significance of the transforming growth factor-β signalling pathway in endometrial cancer

2011 ◽  
Vol 59 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Paulette Mhawech-Fauceglia ◽  
Joshua Kesterson ◽  
Dan Wang ◽  
Stacey Akers ◽  
Nefertiti Chianti DuPont ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Growth Factor ◽  
Clinical Significance ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Signalling Pathway

scholarly journals Regulation of transforming growth factor-β signalling by SUMOylation and its role in fibrosis

Open Biology ◽  
2021 ◽  
Vol 11 (11) ◽  
Author(s):  
Xinyi Wang ◽  
Ting Liu ◽  
Yifei Huang ◽  
Yifeng Dai ◽  
Hui Lin
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Epithelial Mesenchymal Transition ◽  
Healing Process ◽  
Transforming Growth Factor Β ◽  
Therapeutic Strategies ◽  
Signalling Pathway ◽  
Signalling Pathways ◽  
Post Translational Modifications ◽  
Mesenchymal Transition

Fibrosis is an abnormal healing process that only repairs the structure of an organ after injury and does not address damaged functions. The pathogenesis of fibrosis is multifactorial and highly complex; numerous signalling pathways are involved in this process, with the transforming growth factor-β (TGF-β) signalling pathway playing a central role. TGF-β regulates the generation of myofibroblasts and the epithelial–mesenchymal transition by regulating transcription and translation of downstream genes and precisely regulating fibrogenesis. The TGF-β signalling pathway can be modulated by various post-translational modifications, of which SUMOylation has been shown to play a key role. In this review, we focus on the function of SUMOylation in canonical and non-canonical TGF-β signalling and its role in fibrosis, providing promising therapeutic strategies for fibrosis.

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