Contribution of hair density and hair diameter to the appearance and progression of androgenetic alopecia in Japanese men

2014 ◽  
Vol 171 (5) ◽  
pp. 1052-1059 ◽  
Author(s):  
A. Ishino ◽  
T. Takahashi ◽  
J. Suzuki ◽  
Y. Nakazawa ◽  
T. Iwabuchi ◽  
...  
Keyword(s):  
Androgenetic Alopecia ◽  
Hair Density ◽  
Japanese Men ◽  
Hair Diameter

Comparison of efficacy of topical 5% minoxidil alone versus topical 5% minoxidil with autologous Platelet Rich Plasma (PRP) therapy in treatment of androgenetic alopecia: A randomised open label study

2021 ◽  
Vol 7 (2) ◽  
pp. 107-114
Author(s):  
Bela Padhiar ◽  
Sruthy Raveendran
Keyword(s):  
Platelet Rich Plasma ◽  
Androgenetic Alopecia ◽  
Androgenic Alopecia ◽  
Open Label ◽  
Hair Density ◽  
Convenience Sample ◽  
Double Spin ◽  
Autologous Platelet Rich Plasma ◽  
Group B ◽  
Autologous Platelet

Androgenic alopecia (AGA) is a type of progressive hairloss, where there is androgen mediated conversion of susceptible terminal hairs into vellus hairs, in genetically predisposed individuals. To compare efficacy of Topical 5% Minoxidil alone versus Topical 5% Minoxidil with Autologous Platelet Rich Plasma (PRP) therapy in patients with Androgenetic Alopecia.This is aProspective study conducted in Department of Dermatology GMERS Medical College, Gandhinagar, Gujarat. A convenience sample of 62 men in the age group of 20-40 with Grade 2-5 AGA according to Hamilton- Norwood Grading were selected and was divided into 2 groups of 31 each. Presitting digital photographs and dermoscopic photos were taken. Autologous PRP was prepared using 18 ml of patients blood after double spin centrifugation and injected by Nappage technique. Results were assessed at the baseline and at the end of each sitting on the basis of change in hair density, photographic evaluation and patient’s self satisfaction. Highly significant increase in hair density was achieved after 4 months of treatment. At T4 (Fourth Session of treatment) Group B showed higher hair density (42.97± 8.96) as compared to Group A (36.94 ± 11.57) which was statistically significant at P = 0.03Group B showed better improvement as compared to Group A.PRP treatment has a positive therapeutic effect on male Androgenetic alopecia without major side effects.

scholarly journals Hair Growth Promotion by Extracts of Inula Helenium and Caesalpinia Sappan Bark in Patients with Androgenetic Alopecia: A Pre-clinical Study Using Phototrichogram Analysis

Cosmetics ◽  
2019 ◽  
Vol 6 (4) ◽  
pp. 66
Author(s):  
Hyoung Chul Choi ◽  
Gae Won Nam ◽  
Noh Hee Jeong ◽  
Bu Young Choi
Keyword(s):  
Clinical Study ◽  
Hair Loss ◽  
Hair Growth ◽  
Blood Circulation ◽  
Growth Promotion ◽  
Test Group ◽  
Androgenetic Alopecia ◽  
Hair Density ◽  
Caesalpinia Sappan ◽  
Inula Helenium

Inula helenium (IH) is known to possess antifungal, anti-bacterial, anti-helminthic, and anti-proliferation activities. Caesalpinia Sappan (CS) is known to reduce inflammation and improve blood circulation. Based on their folkloric use, these plants are expected to be promising candidates for promoting hair growth and preventing hair loss. Moreover, these plants are rich sources of certain phytochemicals, which have been reported to promote hair growth. In this clinical trial, we investigate the efficacy of a scalp shampoo formulated by mixing extracts of IH and CS in preventing hair loss and promoting hair growth in patients with androgenetic alopecia. Using a phototrichogram (Folliscope 2.8, LeadM, Korea), we compared the hair density and total hair counts in patients receiving the scalp shampoo at baseline, and at 8, 16, and 24 weeks after use of the shampoo. We found a statistically significant increase in the total hair count in the test group (n = 23) after 16 and 24 weeks of using the scalp shampoo (2.17 n/cm2 ± 5.72, p < 0.05; and 4.30 n/cm2 ± 6.37, p < 0.01, respectively) as compared to the control subjects. Based on the results of this clinical study, we conclude that the IH and CS extract complex is a promising remedy for preventing hair loss and promoting hair growth.

The topical penta-peptide Gly-Pro-Ile-Gly-Ser increases the proportion of thick hair in Japanese men with androgenetic alopecia

2016 ◽  
Vol 15 (2) ◽  
pp. 176-184 ◽  
Author(s):  
Tokuro Iwabuchi ◽  
Shunsuke Takeda ◽  
Haruyo Yamanishi ◽  
Ritsuro Ideta ◽  
Ritsuko Ehama ◽  
...  
Keyword(s):  
Androgenetic Alopecia ◽  
Japanese Men

scholarly journals IMPROVEMENT OF ALOPECIA AND DECREASES IN HAIR CORTISOL AND DIHYDROTESTOSTERONE CONCENTRATIONS AFTER THE TOPICAL USE OF PLANT EXTRACTS IN MEN WITH ANDROGENETIC ALOPECIA

2021 ◽  
pp. 71-79
Author(s):  
SANG-HWAN DO ◽  
RYUN-SUP AHN ◽  
MYUNG-SUK NA ◽  
HYUNG-RUEL JU
Keyword(s):  
Plant Extracts ◽  
Hair Shaft ◽  
Androgenetic Alopecia ◽  
Hair Cortisol ◽  
Hair Density ◽  
Main Effect ◽  
Assessment Time ◽  
Single Blind ◽  
Single Time Point ◽  
Time Point

Objectives: Plant extracts possessing specific constituents with anti-inflammatory, antimicrobial, antioxidant, or 5α-reductase inhibitory properties are known to provide benefits against androgenetic alopecia (AGA) in men. A solid shampoo was formulated, and it contained a mixture of six different plant extracts that possess these beneficial properties against AGA. The improvement in AGA and changes in steroid concentrations were assessed after 4 months of formulated shampoo use. Methods: This study was conducted based on a randomized, placebo-controlled, and single-blind design. Hair-related variables and hair and saliva samples were collected bi-monthly in the treatment (n=48) and placebo (n=52) groups and at a single time point in the hairy controls (n=50). Results: The formulated shampoo was more effective on AGA than the placebo based on the hair shaft thickness and hair density in the receding hairline. The baseline hair cortisol and dihydrotestosterone (DHT) concentrations were significantly higher in the treatment and placebo groups than in the hairy controls. After 4 months, the hair steroid concentrations in the treatment group were reduced to those observed in the hairy controls, although the main effect of time on hair steroid concentrations was negligible in the placebo group. Salivary cortisol and DHT levels during the post-awakening period were comparable among the groups or assessment time points. Conclusion: The constituents of plant extracts included in the formulated shampoo would prevent hair loss, increase hair growth effects, and reduce hair cortisol and DHT concentrations without changes in the post-awakening salivary steroid levels in men with AGA.

Five-year efficacy of finasteride in 801 Japanese men with androgenetic alopecia

2015 ◽  
Vol 42 (7) ◽  
pp. 735-738 ◽  
Author(s):  
Toshihiro Yoshitake ◽  
Akira Takeda ◽  
Kensaku Ohki ◽  
Yuko Inoue ◽  
Takanori Yamawaki ◽  
...  
Keyword(s):  
Androgenetic Alopecia ◽  
Japanese Men

scholarly journals The Effectiveness and Tolerability of Preformed Growth Factors Vehiculated Through Iontophoresis on Patients with Androgenetic Alopecia and Telogen Effluvium: A Clinical Study

2021 ◽  
pp. 2021082
Author(s):  
Aurora Maria Alessandrini ◽  
Francesca Bruni ◽  
Bianca Maria Piraccini ◽  
Michela Starace
Keyword(s):  
Growth Factors ◽  
Combined Therapy ◽  
Hair Shaft ◽  
Hair Follicles ◽  
Androgenetic Alopecia ◽  
Treatment Modalities ◽  
Self Assessment ◽  
Hair Density ◽  
Pattern Distribution ◽  
Assessment Questionnaire

Background: Androgenetic alopecia is characterized by a progressive miniaturization of hair follicles in a pattern distribution in genetically predisposed individuals. The efficacy of conventional therapies is variable, therefore there is a need for adjuvant and newer treatment modalities to provide faster and better outcomes. Objectives: Evaluation of the efficacy and tolerability of a combined therapy: preformed growth factors vehiculated through iontophoresis in patients with androgenetic alopecia and associated telogen effluvium, to obtain faster hair regrowth. Materials and Methods: Treatment was performed between June 2018 and June 2019 on 60 patients with androgenetic alopecia and associated telogen effluvium. Each patient underwent 4 sessions in total, each session was performed every 3 weeks. Global photography and trichoscopy were collected at every session of therapy. All patients filed out a self-assessment questionnaire. Results: Results were very promising, with improvement of hair density and thickening of the hair shaft diameter in most of patients seen with both global photography and trichoscopy. All patients were satisfied of the clinical result and reported a complete reduction in hair loss. No serious adverse side effects were reported. Conclusions: The use of growth factors associated with iontophoresis technique is a useful treatment for treating and preventing androgenetic alopecia. In addition, in case of associated telogen effluvium, this technique allows for an early stop of hair shedding, especially when cosmetic procedures do not provide satisfactory results in patients.

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