On Mendelian randomization analysis of case‐control study

Biometrics ◽  
2019 ◽  
Vol 76 (2) ◽  
pp. 380-391
Author(s):  
Han Zhang ◽  
Jing Qin ◽  
Sonja I. Berndt ◽  
Demetrius Albanes ◽  
Lu Deng ◽  
...  
Keyword(s):  
Case Control Study ◽  
Mendelian Randomization ◽  
Case Control ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis ◽  
Control Study

Abstract 5093: Genetically Elevated Lipoprotein(a) and Risk of Myocardial Infarction - a Positive Mendelian Randomization Study

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Pia Kamstrup ◽  
Anne Tybjærg-Hansen ◽  
Rolf Steffensen ◽  
Børge G Nordestgaard
Keyword(s):  
Myocardial Infarction ◽  
Plasma Levels ◽  
Case Control Study ◽  
Mendelian Randomization ◽  
Causal Effect ◽  
Case Control ◽  
Lipoprotein A ◽  
Increased Risk ◽  
Disease Study ◽  
Control Study

Background: High levels of lipoprotein(a) (Lp(a)) associate with increased risk of myocardial infarction (MI). We tested whether this is a causal effect using a Mendelian randomization design. Methods: We genotyped for the Lp(a) kringle IV type 2 (KIV-2) size polymorphism, which explains 21% of variation in plasma levels of Lp(a). We used a cohort study of the Danish general population, The Copenhagen City Heart Study, including 9867 individuals followed for up to 16 years during which time 599 developed MI, and a case-control study, The Copenhagen Ischemic Heart Disease Study, including 1118 MI patients and 2234 controls. Results: First, increased plasma levels of Lp(a) associated with increased risk of MI (Lp(a) tertiles, trend: p<0.001). Second, number of KIV-2 repeats inversely associated with Lp(a) levels: mean Lp(a) levels were 56, 31, 20, and 15 mg/dL for the 1 st , 2 nd , 3 rd , and 4 th quartile of KIV-2 repeats, respectively (trend, p<0.001, Figure ). Third, multifactorially adjusted hazard ratios for MI were 1.6(95% CI:1.3–.2.0), 1.3(1.0 –1.7), and 1.1(0.9 –1.4) for individuals in the 1 st , 2 nd , and 3 rd quartile, respectively, as compared to individuals in the 4 th quartile of KIV-2 repeats (Figure ). Finally, in the case-control study, multifactorially adjusted odds ratios for MI were 1.5(1.2–1.9), 1.3(1.0 –1.6), and 1.2(1.0 –1.5) for individuals in the 1 st , 2 nd , and 3 rd quartile, respectively, as compared to individuals in the 4 th quartile of KIV-2 repeats. Conclusion: Since Lp(a) levels predict MI, and since Lp(a) KIV-2 genotype predicts both life-long increased Lp(a) levels and MI, increased Lp(a) levels appear to directly cause MI. Figure. Levels of lipoprotein (a) and risk of myocardial infarction by KIV-2

Precursor lesions of gastric polyps developing during maintenance omeprazole. A case-control study

2001 ◽  
Vol 120 (5) ◽  
pp. A657-A658
Author(s):  
A CATS ◽  
E BLOEMENA ◽  
E SCHENK ◽  
I CLINICS ◽  
S MEUWISSEN ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Precursor Lesions ◽  
Gastric Polyps ◽  
Control Study

Risk factors for esophageal adenocarcinoma: A case-control study

2001 ◽  
Vol 120 (5) ◽  
pp. A442-A442
Author(s):  
B AVIDAN ◽  
A SONNENBERG ◽  
T SCHNELL ◽  
G CHEJFEC ◽  
A METZ ◽  
...  
Keyword(s):  
Risk Factors ◽  
Esophageal Adenocarcinoma ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

130: A Case-Control Study of Medical Co-Morbidities in Women with Interstitial Cystitis

2007 ◽  
Vol 177 (4S) ◽  
pp. 45-45
Author(s):  
J. Quentin Clemens ◽  
Richard T. Meenan ◽  
Maureen C. O’Keeffe Rosetti ◽  
Teresa M. Kimes ◽  
Elizabeth A. Calhoun
Keyword(s):  
Interstitial Cystitis ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

535: Population-Based Case-Control Study of PSA and DRE Screening on Prostate Cancer Mortality

2005 ◽  
Vol 173 (4S) ◽  
pp. 146-146
Author(s):  
Eric J. Bergstralh ◽  
Rosebud O. Roberts ◽  
Michael M. Lieber ◽  
Sara A. Farmer ◽  
Jeffrey M. Slezak ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Mortality ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Prostate Cancer Mortality ◽  
Control Study
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