Mendelian randomization analysis of case-control data using structural mean models

2010 ◽  
Vol 30 (6) ◽  
pp. 678-694 ◽  
Author(s):  
Jack Bowden ◽  
Stijn Vansteelandt
Keyword(s):  
Mendelian Randomization ◽  
Case Control ◽  
Control Data ◽  
Mendelian Randomization Analysis ◽  
Structural Mean Models ◽  
Randomization Analysis

On Mendelian randomization analysis of case‐control study

Biometrics ◽  
2019 ◽  
Vol 76 (2) ◽  
pp. 380-391
Author(s):  
Han Zhang ◽  
Jing Qin ◽  
Sonja I. Berndt ◽  
Demetrius Albanes ◽  
Lu Deng ◽  
...  
Keyword(s):  
Case Control Study ◽  
Mendelian Randomization ◽  
Case Control ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis ◽  
Control Study

Cigarette Smoking Behavior a Gateway to Opium Use Disorder: A Mendelian Randomization Analysis

2021 ◽  
Author(s):  
Abdolhalim Rajabi ◽  
Azadeh Shojaei ◽  
Leila Janani ◽  
Mojtaba Farjam ◽  
Hamid Reza Baradaran ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Mendelian Randomization ◽  
Smoking Behavior ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis ◽  
Opium Use

scholarly journals Testosterone in Female Depression: A Meta-Analysis and Mendelian Randomization Study

Biomolecules ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 409
Author(s):  
Dhruba Tara Maharjan ◽  
Ali Alamdar Shah Syed ◽  
Guan Ning Lin ◽  
Weihai Ying
Keyword(s):  
Mendelian Randomization ◽  
Meta Analysis ◽  
Menopausal Status ◽  
Serum Testosterone ◽  
Serum Levels ◽  
Testosterone Levels ◽  
Mendelian Randomization Analysis ◽  
The Difference ◽  
Diagnostic Capabilities ◽  
Randomization Analysis

Testosterone’s role in female depression is not well understood, with studies reporting conflicting results. Here, we use meta-analytical and Mendelian randomization techniques to determine whether serum testosterone levels differ between depressed and healthy women and whether such a relationship is casual. Our meta-analysis shows a significant association between absolute serum testosterone levels and female depression, which remains true for the premenopausal group while achieving borderline significance in the postmenopausal group. The results from our Mendelian randomization analysis failed to show any causal relationship between testosterone and depression. Our results show that women with depression do indeed display significantly different serum levels of testosterone. However, the directions of the effect of this relationship are conflicting and may be due to menopausal status. Since our Mendelian randomization analysis was insignificant, the difference in testosterone levels between healthy and depressed women is most likely a manifestation of the disease itself. Further studies could be carried out to leverage this newfound insight into better diagnostic capabilities culminating in early intervention in female depression.

scholarly journals Causal Effects of Body Mass Index on Cardiometabolic Traits and Events: A Mendelian Randomization Analysis

2014 ◽  
Vol 94 (2) ◽  
pp. 312 ◽  
Author(s):  
Michael V. Holmes ◽  
Leslie A. Lange ◽  
Tom Palmer ◽  
Matthew B. Lanktree ◽  
Kari E. North ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Mendelian Randomization ◽  
Causal Effects ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis ◽  
Cardiometabolic Traits
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