scholarly journals Comparison of Pharmacokinetics and Tissue Distribution Kinetics of Roxithromycin and Expression of CYP 3A1 between Pregnant Mice and Foetuses

2016 ◽  
Vol 120 (2) ◽  
pp. 146-151 ◽  
Author(s):  
Yi Qin ◽  
Weizhe Xu ◽  
Lanjian Mo ◽  
Xiaorong Li ◽  
Beikang Ge ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Distribution Kinetics ◽  
Pregnant Mice ◽  
Kinetics Of

scholarly journals Pharmacokinetics and Tissue Distribution Kinetics of Puerarin in Rats Using Indirect Competitive ELISA

Molecules ◽  
2017 ◽  
Vol 22 (6) ◽  
pp. 939 ◽  
Author(s):  
Hui Kong ◽  
Xueqian Wang ◽  
Rongfeng Shi ◽  
Yan Zhao ◽  
Jinjun Cheng ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Competitive Elisa ◽  
Indirect Competitive Elisa ◽  
Distribution Kinetics ◽  
Kinetics Of

scholarly journals Pharmacokinetics and Tissue Distribution Kinetics of Puerarin in Rats Using Indirect Competitive ELISA

2017 ◽  
Author(s):  
Hui Kong ◽  
Xueqian Wang ◽  
Rongfeng Shi ◽  
Yan Zhao ◽  
Jinjun Cheng ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Tissue Distribution ◽  
Intraperitoneal Administration ◽  
Competitive Elisa ◽  
Pharmacokinetic Parameters ◽  
High Dose ◽  
Sample Type ◽  
Indirect Competitive Elisa ◽  
Distribution Kinetics ◽  
Kinetics Of

Puerarin (PUE) is a compound isolated from the roots of Pueraria lobata. We studied the pharmacokinetics and tissue distribution kinetics of PUE in Sprague-Dawley rats following intraperitoneal administration of three concentrations. Indirect competitive ELISA based on an anti-PUE monoclonal antibody was used to determine the concentration of PUE in the blood, heart, liver, spleen, lung, kidney, hippocampus, cerebral cortex, and striatum. The plasma and tissue distribution kinetic characteristics following a single injection of PUE (20, 40, and 80 mg/kg) were calculated using a non-compartment model. In the high-dose (80 mg/kg) and medium-dose (40 mg/kg) groups, the kinetic profile of PUE in blood and kidney samples showed two absorption peaks, while that of the other tissues showed only one peak. In the low-dose (20 mg/kg) group, there was only one peak, irrespective of the sample type. Pharmacokinetic parameters such as the area under the curve, Cmax, and Tmax varied according to the administered dose. AUC and Cmax values increased dose-dependently. PUE was widely distributed in areas of the brain such as the hippocampus, cerebral cortex, and striatum, providing a foundation for guiding the use of PUE in the treatment of cerebral ischaemic stroke and neurodegenerative diseases.

Tissue distribution kinetics of tetraethylammonium ion in the rat

1980 ◽  
Vol 8 (4) ◽  
pp. 373-409 ◽  
Author(s):  
Mark Mintun ◽  
Kenneth J. Himmelstein ◽  
Richard L. Schroder ◽  
Milo Gibaldi ◽  
Danny D. Shen
Keyword(s):  
Tissue Distribution ◽  
Distribution Kinetics ◽  
Tetraethylammonium Ion ◽  
Kinetics Of

Interphase distribution of 2-furylethylenes

1985 ◽  
Vol 50 (8) ◽  
pp. 1642-1647 ◽  
Author(s):  
Štefan Baláž ◽  
Anton Kuchár ◽  
Ernest Šturdík ◽  
Michal Rosenberg ◽  
Ladislav Štibrányi ◽  
...  
Keyword(s):  
Partition Coefficient ◽  
Partition Coefficients ◽  
Transport Rate ◽  
Phase System ◽  
Two Phase ◽  
Interphase Distribution ◽  
Distribution Kinetics ◽  
System 1 ◽  
Kinetics Of

The distribution kinetics of 35 2-furylethylene derivatives in two-phase system 1-octanol-water was investigated. The transport rate parameters in direction water-1-octanol (l1) and backwards (l2) are partition coefficient P = l1/l2 dependent according to equations l1 = logP - log(βP + 1) + const., l2 = -log(βP + 1) + const., const. = -5.600, β = 0.261. Importance of this finding for assesment of distribution of compounds under investigation in biosystems and also the suitability of the presented method for determination of partition coefficients are discussed.

The Distribution Kinetics of Topical14C‐Sulfur Mustard in Rabbit Ocular Tissues and the Effect of Acetylcysteine

2003 ◽  
Vol 22 (4) ◽  
pp. 201-214 ◽  
Author(s):  
A. Amir ◽  
T. Kadar ◽  
S. Chapman ◽  
J. Turetz ◽  
A. Levy ◽  
...  
Keyword(s):  
Sulfur Mustard ◽  
Ocular Tissues ◽  
Distribution Kinetics ◽  
Kinetics Of

Kinetics of Plasma and Tissue Distribution of 9-cis-Retinoic Acid in Rat

2000 ◽  
Vol 13 (1) ◽  
pp. 9-16 ◽  
Author(s):  
B. Disdier ◽  
M.N. Marchetti ◽  
H. Bun ◽  
M. Placidi ◽  
A. Durand
Keyword(s):  
Retinoic Acid ◽  
Tissue Distribution ◽  
Kinetics Of
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